| TSPYL1 as a Critical Regulator of TGFbeta Signaling through Repression of TGFBR1 and TSPYL2. | TSPYL1 as a Critical Regulator of TGFβ Signaling through Repression of TGFBR1 and TSPYL2.
Tan H, Miao MX, Luo RX, So J, Peng L, Zhu X, Leung EHW, Zhu L, Chan KM, Cheung M, Chan SY., Free PMC Article | 10/21/2024 |
| CD9 promotes TbetaR2-TbetaR1 association driving the transition of human dermal fibroblasts to myofibroblast under hypoxia. | CD9 promotes TβR2-TβR1 association driving the transition of human dermal fibroblasts to myofibroblast under hypoxia.
Huang W, Zhang Z, Li X, Zheng Q, Wu C, Liu L, Chen Y, Zhang J, Jiang X., Free PMC Article | 10/5/2024 |
| Stabilization of TGF-beta Receptor 1 by a Receptor-Associated Adaptor Dictates Feedback Activation of the TGF-beta Signaling Pathway to Maintain Liver Cancer Stemness and Drug Resistance. | Stabilization of TGF-β Receptor 1 by a Receptor-Associated Adaptor Dictates Feedback Activation of the TGF-β Signaling Pathway to Maintain Liver Cancer Stemness and Drug Resistance.
Liu K, Tian F, Chen X, Liu B, Tian S, Hou Y, Wang L, Han M, Peng S, Tan Y, Pan Y, Chu Z, Li J, Che L, Chen D, Wen L, Qin Z, Li X, Xiang J, Bian XW, Liu Q, Ye X, Wang T, Wang B., Free PMC Article | 10/2/2024 |
| ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFbetaR1 ISGylation. | ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation.
Cui N, Liu C, Tang X, Song L, Xiao Z, Wang C, Wu Y, Zhou Y, Peng C, Liu Y, Zheng L, Liu X, Huang K, Chen H., Free PMC Article | 08/9/2024 |
| Polymorphism of Transforming Growth Factor TGFB and Its Receptors TGFBRI, TGFBRII, TGFBRIIII Genes in Western Siberia Patients with Open-Angle Glaucoma. | Polymorphism of Transforming Growth Factor TGFB and Its Receptors TGFBRI, TGFBRII, TGFBRIIII Genes in Western Siberia Patients with Open-Angle Glaucoma.
Shevchenko AV, Prokofiev VF, Konenkov VI, Chernykh VV, Trunov AN. | 06/17/2024 |
| Gut microbiota regulates the ALK5/NOX1 axis by altering glutamine metabolism to inhibit ferroptosis of intrahepatic cholangiocarcinoma cells. | Gut microbiota regulates the ALK5/NOX1 axis by altering glutamine metabolism to inhibit ferroptosis of intrahepatic cholangiocarcinoma cells.
Zhang Q, Zhou J, Zhai D, Jiang Q, Yang M, Zhou M. | 05/29/2024 |
| Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition. | Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.
Cai Y, Zhou Y, Yang Q, Xu J, Da Q, Ma Q, Zhao D, Lu T, Kim HW, Fulton D, Jiang X, Weintraub NL, Dong K, Xu S, Hong M, Liu Z, Huo Y. | 05/23/2024 |
| TGFbetaR1 inhibition drives hepatocellular carcinoma proliferation through induction of toll-like-receptor signalling. | TGFβR1 inhibition drives hepatocellular carcinoma proliferation through induction of toll-like-receptor signalling.
Mohamed FEZA, Dewidar B, Lin T, Ebert MP, Dooley S, Meindl-Beinker NM, Hammad S., | 03/21/2024 |
| Exosomes from human adipose-derived mesenchymal stem cells attenuate localized scleroderma fibrosis by the let-7a-5p/TGF-betaR1/Smad axis. | Exosomes from human adipose-derived mesenchymal stem cells attenuate localized scleroderma fibrosis by the let-7a-5p/TGF-βR1/Smad axis.
Wang L, Li T, Ma X, Li Y, Li Z, Li Z, Yu N, Huang J, Han Q, Long X. | 12/20/2023 |
| Functional Genetic Variants in TGFbeta1 and TGFbetaR1 in miRNA-Binding Sites Predict Outcomes in Patients with HPV-positive Oropharyngeal Squamous Cell Carcinoma. | Functional Genetic Variants in TGFβ1 and TGFβR1 in miRNA-Binding Sites Predict Outcomes in Patients with HPV-positive Oropharyngeal Squamous Cell Carcinoma.
Niu Z, Sun P, Liu H, Wei P, Wu J, Huang Z, Gross ND, Shete S, Wei Q, Zafereo ME, Calin GA, Li G. | 11/10/2023 |
| Truncating variants in the penultimate exon of TGFBR1 escaping nonsense-mediated mRNA decay cause Loeys-Dietz syndrome. | Truncating variants in the penultimate exon of TGFBR1 escaping nonsense-mediated mRNA decay cause Loeys-Dietz syndrome.
Fortugno P, Monetta R, Cinquina V, Rigon C, Boaretto F, De Luca C, Zoppi N, Di Leandro L, De Domenico E, Di Daniele A, Ippoliti R, Angelucci F, Di Cesare E, De Paulis R, Salviati L, Colombi M, Brancati F, Ritelli M., Free PMC Article | 08/25/2023 |
| Transforming growth factor beta isoforms and TGF-betaR1 and TGF-betaR2 expression in systemic sclerosis patients. | Transforming growth factor beta isoforms and TGF-βR1 and TGF-βR2 expression in systemic sclerosis patients.
Lomelí-Nieto JA, Muñoz-Valle JF, Baños-Hernández CJ, Navarro-Zarza JE, Godínez-Rubí JM, García-Arellano S, Ramírez-Dueñas MG, Parra-Rojas I, Villanueva-Pérez A, Hernández-Bello J. | 05/30/2023 |
| Crosstalk between protein kinase C alpha and transforming growth factor beta signaling mediated by Runx2 in intestinal epithelial cells. | Crosstalk between protein kinase C α and transforming growth factor β signaling mediated by Runx2 in intestinal epithelial cells.
Li X, Kaur N, Albahrani M, Karpf AR, Black AR, Black JD., Free PMC Article | 05/17/2023 |
| LncRNA LITATS1 suppresses TGF-beta-induced EMT and cancer cell plasticity by potentiating TbetaRI degradation. | LncRNA LITATS1 suppresses TGF-β-induced EMT and cancer cell plasticity by potentiating TβRI degradation.
Fan C, Wang Q, Kuipers TB, Cats D, Iyengar PV, Hagenaars SC, Mesker WE, Devilee P, Tollenaar RAEM, Mei H, Ten Dijke P., Free PMC Article | 05/17/2023 |
| Siblings with profound connective tissue disease: First report of biallelic TGFBR1-related Loeys-Dietz syndrome. | Siblings with profound connective tissue disease: First report of biallelic TGFBR1-related Loeys-Dietz syndrome.
Starr LJ, Lindsay ME, Lino Cardenas CL, Yetman AT. | 02/15/2023 |
| Shear-mediated ALK5 expression regulates endothelial activation. | Shear-mediated ALK5 expression regulates endothelial activation.
Pang KT, Ghim M, Sarathchandra P, Warboys CM, Yacoub MH, Chester AH, Weinberg PD. | 02/11/2023 |
| GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/beta-catenin and ALK5/SMAD2/3 pathways. | GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/β-catenin and ALK5/SMAD2/3 pathways.
Frohlich J, Kovacovicova K, Raffaele M, Virglova T, Cizkova E, Kucera J, Bienertova-Vasku J, Wabitsch M, Peyrou M, Bonomini F, Rezzani R, Chaldakov GN, Tonchev AB, Di Rosa M, Blavet N, Hejret V, Vinciguerra M., Free PMC Article | 10/8/2022 |
| The ubiquitin-ligase TRAF6 and TGFbeta type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells. | The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells.
Song J, Zhou Y, Yakymovych I, Schmidt A, Li C, Heldin CH, Landström M., Free PMC Article | 08/27/2022 |
| Association of gene polymorphisms in MYH11 and TGF-beta signaling with the susceptibility and clinical outcomes of DeBakey type III aortic dissection. | Association of gene polymorphisms in MYH11 and TGF-β signaling with the susceptibility and clinical outcomes of DeBakey type III aortic dissection.
Chang Y, Yuan Q, Jiang P, Sun L, Ma Y, Ma X. | 08/13/2022 |
| miR-98-5p as a novel biomarker suppress liver fibrosis by targeting TGFbeta receptor 1. | miR-98-5p as a novel biomarker suppress liver fibrosis by targeting TGFβ receptor 1.
Ma Y, Yuan X, Han M, Xu Y, Han K, Liang P, Liu S, Chen J, Xing H. | 06/18/2022 |
| Akt acts as a switch for GPCR transactivation of the TGF-beta receptor type 1. | Akt acts as a switch for GPCR transactivation of the TGF-β receptor type 1.
Mohamed R, Shajimoon A, Afroz R, Gabr M, Thomas WG, Little PJ, Kamato D. | 05/7/2022 |
| Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration. | Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration.
Hillege MMG, Shi A, Galli RA, Wu G, Bertolino P, Hoogaars WMH, Jaspers RT., Free PMC Article | 04/23/2022 |
| Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-beta receptor. | Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor.
Babaahmadi-Rezaei H, Little PJ, Mohamed R, Zadeh GM, Kheirollah A, Mehr RN, Kamato D, Dayati P. | 03/26/2022 |
| Expanding the phenotypic spectrum of Mendelian connective tissue disorders to include prominent kidney phenotypes. | Expanding the phenotypic spectrum of Mendelian connective tissue disorders to include prominent kidney phenotypes.
Strong A, Skraban C, Meyers K, Amaral S, Furth S, Drant S, Hsiao W, Galea L, Gold J, Gold NB, Leonard J, Lopez S, Zackai EH, Pyeritz RE., Free PMC Article | 03/5/2022 |
| hiPSC Modeling of Lineage-Specific Smooth Muscle Cell Defects Caused by TGFBR1(A230T) Variant, and Its Therapeutic Implications for Loeys-Dietz Syndrome. | hiPSC Modeling of Lineage-Specific Smooth Muscle Cell Defects Caused by TGFBR1(A230T) Variant, and Its Therapeutic Implications for Loeys-Dietz Syndrome.
Zhou D, Feng H, Yang Y, Huang T, Qiu P, Zhang C, Olsen TR, Zhang J, Chen YE, Mizrak D, Yang B., Free PMC Article | 02/12/2022 |