| Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population. | Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population.
Ashiq S, Sabar MF. | 05/30/2023 |
| Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma. | Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.
Matsumoto T, Chino H, Akiya M, Hashimura M, Yokoi A, Tochimoto M, Nakagawa M, Jiang Z, Saegusa M. | 01/23/2021 |
| LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-beta1/Smad3 pathway. | LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.
Yang YR, Bu FT, Yang Y, Li H, Huang C, Meng XM, Zhang L, Lv XW, Li J. | 11/21/2020 |
| The present study demonstrates a novel role of LEFTY2 in up-regulating transcript levels and protein abundance of the Na+ coupled glucose transporter SGLT1, thus stimulating cellular glucose uptake and cellular formation of glycogen in endometrial cancer cells. | LEFTY2/endometrial bleeding-associated factor up-regulates Na+ Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells.
Zeng N, Okumura T, Alauddin M, Khozooei S, Rajaxavier J, Zhang S, Singh Y, Shi B, Brucker SY, Wallwiener D, Takeda S, Lang F, Salker MS., Free PMC Article | 07/18/2020 |
| In a reaction-diffusion pattern, the effective range of Nodal is 3.5 times narrower than that of Lefty2. | Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty.
Sekine R, Shibata T, Ebisuya M., Free PMC Article | 02/23/2019 |
| functional role of LEFTY during progesterone therapy for endometrial carcinoma | A functional role of LEFTY during progesterone therapy for endometrial carcinoma.
Fei W, Kijima D, Hashimoto M, Hashimura M, Oguri Y, Kajita S, Matsumoto T, Yokoi A, Saegusa M., Free PMC Article | 10/6/2018 |
| LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. | LeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer Cells.
Salker MS, Schierbaum N, Alowayed N, Singh Y, Mack AF, Stournaras C, Schäffer TE, Lang F., Free PMC Article | 07/7/2018 |
| LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. | LEFTY2 Controls Migration of Human Endometrial Cancer Cells via Focal Adhesion Kinase Activity (FAK) and miRNA-200a.
Alowayed N, Salker MS, Zeng N, Singh Y, Lang F. | 02/4/2017 |
| LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. | LEFTYA Activates the Epithelial Na+ Channel (ENaC) in Endometrial Cells via Serum and Glucocorticoid Inducible Kinase SGK1.
Salker MS, Hosseinzadeh Z, Alowayed N, Zeng N, Umbach AT, Webster Z, Singh Y, Brosens JJ, Lang F. | 02/4/2017 |
| Lefty A may account for the tumor suppressive activity of human adult stem cells. | Role of Lefty in the anti tumor activity of human adult liver stem cells.
Cavallari C, Fonsato V, Herrera MB, Bruno S, Tetta C, Camussi G. | 04/13/2013 |
| Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. | The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells.
Barroso-delJesus A, Lucena-Aguilar G, Sanchez L, Ligero G, Gutierrez-Aranda I, Menendez P. | 07/2/2011 |
| Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. | Isolation, characterization, and function of EBAF/LEFTY B: role in infertility.
Tabibzadeh S. | 05/7/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesA large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. | 09/15/2010 |
| findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression | Distinct tumor specific expression of TGFB4 (ebaf)*, a novel human gene of the TGF-beta superfamily.
Tabibzadeh S, Kothapalli R, Buyuksal I. | 01/21/2010 |
| Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. | Regulation of matrix metalloproteinase-9/gelatinase B expression and activation by ovarian steroids and LEFTY-A/endometrial bleeding-associated factor in the human endometrium.
Cornet PB, Galant C, Eeckhout Y, Courtoy PJ, Marbaix E, Henriet P. | 01/21/2010 |
| may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases | Regulation and function of LEFTY-A/EBAF in the human endometrium. mRNA expression during the menstrual cycle, control by progesterone, and effect on matrix metalloprotineases.
Cornet PB, Picquet C, Lemoine P, Osteen KG, Bruner-Tran KL, Tabibzadeh S, Courtoy PJ, Eeckhout Y, Marbaix E, Henriet P. | 01/21/2010 |
| LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. | Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.
Dvash T, Sharon N, Yanuka O, Benvenisty N. | 01/21/2010 |
| nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells | Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.
Besser D. | 01/21/2010 |