| ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in ovarian cancer cells. | ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in ovarian cancer cells.
Zhao R, Song N, Ning X, Chen X, Ma R. | 06/14/2024 |
| Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer. | Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.
Wu M, Ye M. | 09/19/2023 |
| miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells. | miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells.
Morimoto Y, Mizushima T, Wu X, Okuzaki D, Yokoyama Y, Inoue A, Hata T, Hirose H, Qian Y, Wang J, Miyoshi N, Takahashi H, Haraguchi N, Matsuda C, Doki Y, Mori M, Yamamoto H., Free PMC Article | 01/16/2021 |
| It uncovered E2F1 and TFDP1 as transport substrates of KPNA2 being retained in the cytoplasm upon KPNA2 ablation, thereby resulting in reduced STMN1 expression. | Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.
Drucker E, Holzer K, Pusch S, Winkler J, Calvisi DF, Eiteneuer E, Herpel E, Goeppert B, Roessler S, Ori A, Schirmacher P, Breuhahn K, Singer S., Free PMC Article | 10/3/2020 |
| We observed a downregulation of TFDP1 in the endometrium cells of women with deep infiltrating endometriosis when compared to the controls | Expression of the TFDP1 gene in the endometrium of women with deep infiltrating endometriosis.
Jibrim RLM, de Carvalho CV, Invitti AL, Schor E. | 12/7/2019 |
| DILC may mediate the crosstalk between the cascades of IL6/STAT3 and TNFalpha signaling, indicating that DILC may act as a prognostic biomarker of sepsis, and may serve as a potential therapeutic target for the treatment of sepsis. | Long non‑coding RNA DILC is involved in sepsis by modulating the signaling pathway of the interleukin‑6/signal transducer and activator of transcription 3/Toll‑like receptor 4 axis.
Huang W, Huang L, Wen M, Fang M, Deng Y, Zeng H. | 02/2/2019 |
| COMMD9 participates in TFDP1/E2F1 activation and plays a critical role in non-small cell lung cancer. | COMMD9 promotes TFDP1/E2F1 transcriptional activity via interaction with TFDP1 in non-small cell lung cancer.
Zhan W, Wang W, Han T, Xie C, Zhang T, Gan M, Wang JB. | 12/2/2017 |
| Here, the authors show that an acidic region of DP1, whose function has remained elusive, binds to the plekstrin homology (PH) domain of the p62 subunit of TFIIH that contributes to transcriptional activation. | The Interaction Mode of the Acidic Region of the Cell Cycle Transcription Factor DP1 with TFIIH.
Okuda M, Araki K, Ohtani K, Nishimura Y. | 07/1/2017 |
| role for E2F1 and TFDP1 in the transcriptional regulation of PITX1 in articular chondrocytes | E2F1 and TFDP1 Regulate PITX1 Expression in Normal and Osteoarthritic Articular Chondrocytes.
Pellicelli M, Picard C, Wang D, Lavigne P, Moreau A., Free PMC Article | 07/1/2017 |
| According to our study results, the gene TFDP1 and the cell cycle pathway are strongly associated with high-grade glioblastoma multiforme (GBM); this result may provide new insights into the pathogenesis of GBM. | Dysregulation of TFDP1 and of the cell cycle pathway in high-grade glioblastoma multiforme: a bioinformatic analysis.
Lu X, Lv XD, Ren YH, Yang WD, Li ZB, Zhang L, Bai XF. | 02/18/2017 |
| Amplification of CUL4A, IRS2, and TFDP1 genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma. | Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma.
Liu TT, You HL, Weng SW, Wei YC, Eng HL, Huang WT., Free PMC Article | 06/28/2016 |
| The TFDP1 indel84 mutation generates a gain-of-function phenotype by increasing cell proliferation, migration, and invasion of colorectal cancer cells. | Next-generation sequencing of colorectal cancers in chinese: identification of a recurrent frame-shift and gain-of-function Indel mutation in the TFDP1 gene.
Chen C, Liu J, Zhou F, Sun J, Li L, Jin C, Shao J, Jiang H, Zhao N, Zheng S, Lin B., Free PMC Article | 06/20/2015 |
| somatic mutations in DP-1 uncouple normal control of the E2F pathway, and thus define a new mechanism that could contribute to aberrant proliferation in tumor cells | Pleiotropic effect of somatic mutations in the E2F subunit DP-1 gene in human cancer.
Munro S, Oppermann U, La Thangue NB. | 09/6/2014 |
| The authors demonstrate that adenovirus E1A binds to E2F/DP-1 complexes through a direct interaction with DP-1 and may selectively activate a subset of E2F-regulated cellular genes during infection. | Adenovirus E1A directly targets the E2F/DP-1 complex.
Pelka P, Miller MS, Cecchini M, Yousef AF, Bowdish DM, Dick F, Whyte P, Mymryk JS., Free PMC Article | 10/8/2011 |
| the DP-1 "Stabilon" domain was a C-terminal acidic motif and was quite important for DP-1 stability. | Identification of significant regions of transcription factor DP-1 (TFDP-1) involved in stability/instability of the protein.
Arakawa T, Masuhiro Y, Kamiya Y, Kojima H, Hanazawa S. | 08/16/2010 |
| 13q34 amplification may be of relevance in tumor progression of breast cancers by inducing overexpression of CUL4A and TFDP1, important in cell cycle regulation. These genes were also overexpressed in non-basal-like tumor samples. | Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes.
Melchor L, Saucedo-Cuevas LP, Muñoz-Repeto I, Rodríguez-Pinilla SM, Honrado E, Campoverde A, Palacios J, Nathanson KL, García MJ, Benítez J., Free PMC Article | 07/12/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
Cunningham JM, Vierkant RA, Sellers TA, Phelan C, Rider DN, Liebow M, Schildkraut J, Berchuck A, Couch FJ, Wang X, Fridley BL, Ovarian Cancer Association Consortium, Gentry-Maharaj A, Menon U, Hogdall E, Kjaer S, Whittemore A, DiCioccio R, Song H, Gayther SA, Ramus SJ, Pharaoh PD, Goode EL., Free PMC Article | 04/7/2010 |
| SOCS-3 acts as a negative regulator of the cell cycle progression under E2F/DP-1 control by interfering with heterodimer formation between DP-1 and E2F | SOCS-3 inhibits E2F/DP-1 transcriptional activity and cell cycle progression via interaction with DP-1.
Masuhiro Y, Kayama K, Fukushima A, Baba K, Soutsu M, Kamiya Y, Gotoh M, Yamaguchi N, Hanazawa S., Free PMC Article | 01/21/2010 |
| DP-1alpha is a novel isoform of DP-1 that acts as a dominant-negative regulator of cell cycle progression | Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner.
Ishida H, Masuhiro Y, Fukushima A, Argueta JG, Yamaguchi N, Shiota S, Hanazawa S. | 01/21/2010 |
| TFDP1, CUL4A, and CDC16 are probable targets of an amplification mechanism and therefore may be involved, together or separately, in development and/or progression of some hepatocellular carcinomas | TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas.
Yasui K, Arii S, Zhao C, Imoto I, Ueda M, Nagai H, Emi M, Inazawa J. | 01/21/2010 |
| DP1 is a critical direct target of ARF. | ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF.
Datta A, Sen J, Hagen J, Korgaonkar CK, Caffrey M, Quelle DE, Hughes DE, Ackerson TJ, Costa RH, Raychaudhuri P., Free PMC Article | 01/21/2010 |
| expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma | Immunohistochemical expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma.
Chan JA, Olvera M, Lai R, Naing W, Rezk SA, Brynes RK. | 01/21/2010 |
| TFDP1 may have a role in progression of some hepatocellular carcinomas by promoting growth of the tumor cells | Association of over-expressed TFDP1 with progression of hepatocellular carcinomas.
Yasui K, Okamoto H, Arii S, Inazawa J. | 01/21/2010 |