| AP-2alpha/AP-2beta Transcription Factors Are Key Regulators of Epidermal Homeostasis. | AP-2α/AP-2β Transcription Factors Are Key Regulators of Epidermal Homeostasis.
Zhang H, Raymundo JR, Daly KE, Zhu W, Senapati B, Zhong H, Ahilan AR, Marneros AG., | 07/11/2024 |
| Novel Circular RNA CircUBAP2 Drives Tumor Progression by Regulating the miR-143/TFAP2B Axis in Prostate Cancer. | Novel Circular RNA CircUBAP2 Drives Tumor Progression by Regulating the miR-143/TFAP2B Axis in Prostate Cancer.
Lv Z, Shi Y, Wu H, Cao K, Liu X, Wang C. | 03/12/2024 |
| Transcription factor activating enhancer-binding protein 2B expression correlates with invasiveness and prognosis of extramammary Paget's disease. | Transcription factor activating enhancer-binding protein 2B expression correlates with invasiveness and prognosis of extramammary Paget's disease.
Kawaguchi A, Akiba J, Ogasawara S, Kondo R, Naito Y, Kusano H, Sanada S, Muto I, Nakama T, Yano H. | 02/22/2023 |
| TRIM37 Augments AP-2gamma Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression. | TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression.
Cui G, Gao Z, Chang S, Narwade N, Chen Y, Poudel B, Lei KMK, Zhang W, Li G, Poon TCW, Cheung E., Free PMC Article | 07/30/2022 |
| Co-expression of transcription factor AP-2beta (TFAP2B) and GATA3 in human mammary epithelial cells with intense, apicobasal immunoreactivity for CK8/18. | Co-expression of transcription factor AP-2beta (TFAP2B) and GATA3 in human mammary epithelial cells with intense, apicobasal immunoreactivity for CK8/18.
Raap M, Gierendt L, Werlein C, Kuehnle E, Kreipe HH, Christgen M., Free PMC Article | 03/12/2022 |
| Transcription factor AP-2beta in development, differentiation and tumorigenesis. | Transcription factor AP-2beta in development, differentiation and tumorigenesis.
Raap M, Gierendt L, Kreipe HH, Christgen M. | 09/18/2021 |
| Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma. | Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma.
Cheng C, Ai Z, Zhao L. | 07/3/2021 |
| TFAP2B, AP-1 and JAZF1 Expression in Tissues of Papillary Thyroid Carcinoma Patients; Clinical, Pathological and Prognostic Values. | TFAP2B, AP-1 and JAZF1 Expression in Tissues of Papillary Thyroid Carcinoma Patients; Clinical, Pathological and Prognostic Values.
A Abuderman A, A Harb O, M Gertallah L, Makki Almansour N., Free PMC Article | 06/5/2021 |
| The role of reward sensitivity in obesity and its association with Transcription Factor AP-2B: A longitudinal birth cohort study. | The role of reward sensitivity in obesity and its association with Transcription Factor AP-2B: A longitudinal birth cohort study.
Katus U, Villa I, Ringmets I, Pulver A, Veidebaum T, Harro J. | 05/15/2021 |
| TFAP2B bound to the promoter of COX-2 to activate its expression, indicating that TFAP2B is a critical regulatory molecule in the COX-2 signaling pathway that promoted tumor progression in thyroid cancer. | TFAP2B overexpression contributes to tumor growth and progression of thyroid cancer through the COX-2 signaling pathway.
Fu X, Zhang H, Chen Z, Yang Z, Shi D, Liu T, Chen W, Yao F, Su X, Deng W, Chen M, Yang A., Free PMC Article | 06/27/2020 |
| PKD knockdown in human umbilical vein endothelial cells increases binding of AP2beta to the VEGFR-2 promoter. | Protein kinase D up-regulates transcription of VEGF receptor-2 in endothelial cells by suppressing nuclear localization of the transcription factor AP2β.
Wang Y, Hoeppner LH, Angom RS, Wang E, Dutta S, Doeppler HR, Wang F, Shen T, Scarisbrick IA, Guha S, Storz P, Bhattacharya R, Mukhopadhyay D., Free PMC Article | 06/6/2020 |
| Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis have been reported. | Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis.
Timberlake AT, Jin SC, Nelson-Williams C, Wu R, Furey CG, Islam B, Haider S, Loring E, Galm A, Yale Center for Genome Analysis, Steinbacher DM, Larysz D, Staffenberg DA, Flores RL, Rodriguez ED, Boggon TJ, Persing JA, Lifton RP., Free PMC Article | 04/4/2020 |
| AP-2beta is a binding partner for DHX33 which acts as a coactivator for AP-2beta to promote the transcription of antiapoptotic Bcl-2 gene. | DHX33 Interacts with AP-2β To Regulate Bcl-2 Gene Expression and Promote Cancer Cell Survival.
Wang J, Feng W, Yuan Z, Weber JD, Zhang Y., Free PMC Article | 02/5/2020 |
| A polymorphic Alu in the flanking region of the TFAP2B and TFAP2D genes has been identified. The new insert was found in higher frequency in Europeans (0.4) and Asians (0.38) and lower frequency in Africans (0.25). | A human specific Alu DNA cassette is found flanking the genes of transcription factor AP2.
Hamdi HK, Reddy S, Laz N, Eltaher R, Kandell Z, Mahmud T, Alenazi L, Haroun B, Hassan M, Ragavendra R., Free PMC Article | 08/17/2019 |
| These findings suggest that TFAP2B transcriptionally regulates CEC-specific genes and therefore may be an important transcriptional regulator of corneal endothelial development and homeostasis. | Transcription factor TFAP2B up-regulates human corneal endothelial cell-specific genes during corneal development and maintenance.
Hara S, Kawasaki S, Yoshihara M, Winegarner A, Busch C, Tsujikawa M, Nishida K., Free PMC Article | 05/4/2019 |
| Data suggest that expression of TFAP2B in lobular carcinoma in situ and invasive lobular breast cancer is up-regulated as compared to control mammary gland epithelium; TFAP2B appear to be involved in regulation of cell proliferation in these slow-growing breast cancer subtypes. | Lobular carcinoma in situ and invasive lobular breast cancer are characterized by enhanced expression of transcription factor AP-2β.
Raap M, Gronewold M, Christgen H, Glage S, Bentires-Alj M, Koren S, Derksen PW, Boelens M, Jonkers J, Lehmann U, Feuerhake F, Kuehnle E, Gluz O, Kates R, Nitz U, Harbeck N, Kreipe HH, Christgen M. | 12/22/2018 |
| previously, only 10 different pathogenic variants in the TFAP2B gene have been associated with the Char syndrome and patent ductus arteriosus (human gene mutation database subscription). We have thus identified the 11th mutation, namely, c.851T>C, p. Leu284Ser, which cosegregates with the phenotype. | A study of familial Char syndrome involving the TFAP2B gene with a focus on facial shape characteristics.
Nyboe D, Kreiborg S, Darvann T, Dunø M, Nissen KR, Hove HB. | 10/20/2018 |
| study demonstrates that AP-2beta promotes tumor growth and predicts poor prognosis, and may represent a potential therapeutic target for breast cancer. | Activator Protein-2β Promotes Tumor Growth and Predicts Poor Prognosis in Breast Cancer.
Li Z, Xu X, Luo M, Hao J, Zhao S, Yu W, Xiao X, Wu J, Zheng F, Chen M, Li Y, Qin G, Liao Y, Zhao X, Yu X, Guo W, Zou L, Deng W. | 08/18/2018 |
| Reduced TFAP2B expression in EC was significantly associated with high grade (OR=2.2 for well, moderate vs. poor), stage (OR=2.5 for I vs. IV), histology (OR=1.8 for serous vs. endometrioid), distant metastasis (OR=2.4 for positive vs. negative) (all p-values<0.05). | Decreased expression of TFAP2B in endometrial cancer predicts poor prognosis: A study based on TCGA data.
Wu H, Zhang J. | 08/11/2018 |
| TFAP2B mutation is associated with tooth abnormalities. | TFAP2B mutation and dental anomalies.
Tanasubsinn N, Sittiwangkul R, Pongprot Y, Kawasaki K, Ohazama A, Sastraruji T, Kaewgahya M, Kantaputra PN., Free PMC Article | 05/19/2018 |
| AP-2 beta and beta-catenin interact both in vitro through GST pull-down assays and in vivo by co-immunoprecipitation. We further identified the interaction regions to the DNA-binding domain of AP-2 beta and the 1-9 Armadillo repeats of beta-catenin. | Transcription factor AP-2β suppresses cervical cancer cell proliferation by promoting the degradation of its interaction partner β-catenin.
Wang F, Huang W, Hu X, Chen C, Li X, Qiu J, Liang Z, Zhang J, Li L, Wang X, Ding X, Xiang S, Zhang J. | 09/30/2017 |
| Single nucleotide polymorphisms (SNP) in angiotensin II receptor, type 1 (AGTR1), transcription factor AP-2 beta (TFAP2B), and tumor necrosis factor receptor-associated factor 1 (TRAF1) have been reported to be associated with the incidence of PDA in preterm infants. | Single nucleotide polymorphisms in AGTR1, TFAP2B, and TRAF1 are not associated with the incidence of patent ductus arteriosus in Japanese preterm infants.
Kawase K, Sugiura T, Nagaya Y, Yamada T, Sugimoto M, Ito K, Togawa T, Nagasaki R, Kato T, Kouwaki M, Koyama N, Saitoh S. | 04/8/2017 |
| results suggest that TFAP2B is playing a vital role in retaining retinoic acid responsiveness and mediating noradrenergic neuronal differentiation in neuroblastoma. | Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma.
Ikram F, Ackermann S, Kahlert Y, Volland R, Roels F, Engesser A, Hertwig F, Kocak H, Hero B, Dreidax D, Henrich KO, Berthold F, Nürnberg P, Westermann F, Fischer M., Free PMC Article | 10/29/2016 |
| The presence of the nine-repeat variant of the TFAP-2beta intron 1 VNTR appears to protect girls with ADHD symptoms from the co-expression of symptoms of depression. | Transcription Factor Activating Protein-2β (TFAP-2β) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples.
Nilsson KW, Sonnby K, Nordquist N, Comasco E, Leppert J, Oreland L, Sjöberg RL. | 09/10/2016 |
| The expression of TFAP-2beta mRNA in tissue of patients with endometrial carcinoma was higher than that of normal endometrium. The expression of TFAP-2beta mRNA in endometrial tissue of patients with metabolism syndrome was higher than that of lean ones. | Correlation between transcription factor activator protein-2β (TFAP-2β) and endometrial carcinoma.
Cui P, Shi K, Cui HX, Hao LY, Su Y, Li PL. | 08/8/2015 |