| STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent. | STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent.
Zhang X, Chen Q, He Y, Shi Q, Yin C, Xie Y, Yu H, Bao Y, Wang X, Tang C, Dong Z., Free PMC Article | 01/21/2023 |
| miR302d3p regulates the viability, migration and apoptosis of breast cancer cells through regulating the TMBIM6mediated ERK signaling pathway. | miR‑302d‑3p regulates the viability, migration and apoptosis of breast cancer cells through regulating the TMBIM6‑mediated ERK signaling pathway.
Liao Y, Qiu Z, Bai L., Free PMC Article | 02/5/2022 |
| TMBIM6 regulates redox-associated posttranslational modifications of IRE1alpha and ER stress response failure in aging mice and humans. | TMBIM6 regulates redox-associated posttranslational modifications of IRE1α and ER stress response failure in aging mice and humans.
Bhattarai KR, Kim HK, Chaudhary M, Ur Rashid MM, Kim J, Kim HR, Chae HJ., Free PMC Article | 12/18/2021 |
| TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium. | TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium.
Kim HK, Lee GH, Bhattarai KR, Lee MS, Back SH, Kim HR, Chae HJ., Free PMC Article | 12/4/2021 |
| RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent. | RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent.
Wang X, Tian L, Li Y, Wang J, Yan B, Yang L, Li Q, Zhao R, Liu M, Wang P, Sun Y., Free PMC Article | 10/23/2021 |
| Long non-coding RNA plasmacytoma variant translocation 1 (PVT1) promotes glioblastoma multiforme progression via regulating miR-1301-3p/TMBIM6 axis. | Long non-coding RNA plasmacytoma variant translocation 1 (PVT1) promotes glioblastoma multiforme progression via regulating miR-1301-3p/TMBIM6 axis.
Jin Z, Piao LH, Sun GC, Lv CX, Jing Y, Jin RH. | 07/3/2021 |
| Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic Reticulum Stress. | Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic Reticulum Stress.
Chang X, Zhang T, Meng Q, ShiyuanWang, Yan P, Wang X, Luo D, Zhou X, Ji R., Free PMC Article | 06/12/2021 |
| TMBIM6, a potential virus target protein identified by integrated multiomics data analysis in SARS-CoV-2-infected host cells. | TMBIM6, a potential virus target protein identified by integrated multiomics data analysis in SARS-CoV-2-infected host cells.
Han Q, Wang J, Luo H, Li L, Lu X, Liu A, Deng Y, Jiang Y., Free PMC Article | 05/15/2021 |
| Bax inhibitor 1 preserves mitochondrial homeostasis in acute kidney injury through promoting mitochondrial retention of PHB2. | Bax inhibitor 1 preserves mitochondrial homeostasis in acute kidney injury through promoting mitochondrial retention of PHB2.
Wang J, Zhu P, Li R, Ren J, Zhang Y, Zhou H., Free PMC Article | 04/3/2021 |
| BAX inhibitor-1: between stress and survival. | BAX inhibitor-1: between stress and survival.
Lebeaupin C, Blanc M, Vallée D, Keller H, Bailly-Maitre B., Free PMC Article | 01/23/2021 |
| TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation. | TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation.
Kim HK, Bhattarai KR, Junjappa RP, Ahn JH, Pagire SH, Yoo HJ, Han J, Lee D, Kim KW, Kim HR, Chae HJ., Free PMC Article | 09/12/2020 |
| stable interacting partner of presenilin 1 (PS1), but not the intact gamma-secretase | Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein.
Wu S, Song W, Wong CCL, Shi Y., Free PMC Article | 03/23/2019 |
| Targeting IRE1alpha-dependent NLRP3 inflammasome signaling with pharmacological agents or by BI-1 may represent a tangible therapeutic strategy for nonalcoholic steatohepatitis | Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice.
Lebeaupin C, Vallée D, Rousseau D, Patouraux S, Bonnafous S, Adam G, Luciano F, Luci C, Anty R, Iannelli A, Marchetti S, Kroemer G, Lacas-Gervais S, Tran A, Gual P, Bailly-Maitre B. | 02/2/2019 |
| BI-1 is overexpressed and promotes the progression and metastasis of non-small cell lung cancer | Bax inhibitor-1 is overexpressed in non-small cell lung cancer and promotes its progression and metastasis.
Lu B, Li Y, Li H, Zhang Y, Xu J, Ren L, Fu S, Zhou Y., Free PMC Article | 03/12/2016 |
| These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca(2) homeostasis in a wide variety of tissues | The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.
Lisak DA, Schacht T, Enders V, Habicht J, Kiviluoto S, Schneider J, Henke N, Bultynck G, Methner A. | 10/3/2015 |
| Bax inhibitor-1 is likely a pH-sensitive calcium leak channel, not a H+/Ca2+ exchanger. | Bax inhibitor-1 is likely a pH-sensitive calcium leak channel, not a H+/Ca2+ exchanger.
Bultynck G, Kiviluoto S, Methner A. | 05/30/2015 |
| BI-1 enhances glucose metabolism, leading to high activation of the sodium/hydrogen exchange for intracellular pH homeostasis. | BI-1 enhances Fas-induced cell death through a Na+/H+-associated mechanism.
Lee GH, Kim HR, Chae HJ., Free PMC Article | 03/21/2015 |
| Results highlight the regulatory role of BI-1 in idiopathic pulmonary fibrosis. | BAX inhibitor-1-associated V-ATPase glycosylation enhances collagen degradation in pulmonary fibrosis.
Lee MR, Lee GH, Lee HY, Kim DS, Chung MJ, Lee YC, Kim HR, Chae HJ., Free PMC Article | 10/25/2014 |
| The effect of Bax Inhibitor-1(TMBIM6) as a regulatorof endoplasmic reticulum Ca2+ homeostasis is regulated by intracellular pH by removing negative charges. | Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis.
Kiviluoto S, Luyten T, Schneider L, Lisak D, Rojas-Rivera D, Welkenhuyzen K, Missaen L, De Smedt H, Parys JB, Hetz C, Methner A, Bultynck G. | 03/15/2014 |
| Constructed lentivirus expression vector for transfecting BI-1. | Construction and identification of the recombinant lentiviral expression vector targeting human BAX inhibitor-1 gene.
Luo HQ, Zhong WT, Liu FM, Cui ZY, Zhou KY, Li XY. | 03/15/2014 |
| Data indicate that GAAP and BI-1 have a six membrane-spanning topology with cytosolic N and C termini and a C-terminal reentrant loop. | Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family.
Carrara G, Saraiva N, Gubser C, Johnson BF, Smith GL., Free PMC Article | 08/4/2012 |
| The results reveal BI-1 as a novel autophagy regulator that bridges Ca(2) signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress. | Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy.
Sano R, Hou YC, Hedvat M, Correa RG, Shu CW, Krajewska M, Diaz PW, Tamble CM, Quarato G, Gottlieb RA, Yamaguchi M, Nizet V, Dahl R, Thomas DD, Tait SW, Green DR, Fisher PB, Matsuzawa S, Reed JC., Free PMC Article | 08/4/2012 |
| The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. | The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
Bultynck G, Kiviluoto S, Henke N, Ivanova H, Schneider L, Rybalchenko V, Luyten T, Nuyts K, De Borggraeve W, Bezprozvanny I, Parys JB, De Smedt H, Missiaen L, Methner A., Free PMC Article | 03/17/2012 |
| Lentivirus-mediated RNA interference targeting Bax inhibitor-1 suppresses ex vivo cell proliferation and in vivo tumor growth of nasopharyngeal carcinoma. | Lentivirus-mediated RNA interference targeting Bax inhibitor-1 suppresses ex vivo cell proliferation and in vivo tumor growth of nasopharyngeal carcinoma.
Li XY, Lai YK, Zhang JF, Luo HQ, Zhang MH, Zhou KY, Kung HF. | 02/25/2012 |
| highly maintained lysosomal activity may be one of the mechanisms by which BI-1 exerts its regulatory effects on the ER stress response and cell death. | Enhanced lysosomal activity is involved in Bax inhibitor-1-induced regulation of the endoplasmic reticulum (ER) stress response and cell death against ER stress: involvement of vacuolar H+-ATPase (V-ATPase).
Lee GH, Kim DS, Kim HT, Lee JW, Chung CH, Ahn T, Lim JM, Kim IK, Chae HJ, Kim HR., Free PMC Article | 01/28/2012 |