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    TEAD4 TEA domain transcription factor 4 [ Homo sapiens (human) ]

    Gene ID: 7004, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Reappraisal of psoriasis pathogenesis: the role of TEAD4 expression in keratinocytes.

    Reappraisal of psoriasis pathogenesis: the role of TEAD4 expression in keratinocytes.
    Shehata WA, Hammam MA, Elbakly AR, Elkady N.

    10/21/2024
    KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL/OPG ratio on the compression side during orthodontic tooth movement.

    KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL/OPG ratio on the compression side during orthodontic tooth movement.
    Tan K, Wang J, Su X, Zheng Y, Li W., Free PMC Article

    09/19/2024
    RBM8A, a new target of TEAD4, promotes breast cancer progression by regulating IGF1R and IRS-2.

    RBM8A, a new target of TEAD4, promotes breast cancer progression by regulating IGF1R and IRS-2.
    Li F, Wang X, Zhang J, Zhang J, Jing X, Jiang Q, Zhou J, Cao L, Peng H, Tong D, Huang C., Free PMC Article

    09/5/2024
    TEAD4 Activates PCSK9 to Promote Stomach Adenocarcinoma Cell Stemness through Fatty Acid Metabolism.

    TEAD4 Activates PCSK9 to Promote Stomach Adenocarcinoma Cell Stemness through Fatty Acid Metabolism.
    Xu D, Han G, Zhou X, Yong H, Jia Y, Zhao F, Shi H.

    08/22/2024
    Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.

    Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.
    Zhu M, Meglicki M, Lamba A, Wang P, Royer C, Turner K, Jauhar MA, Jones C, Child T, Coward K, Na J, Zernicka-Goetz M., Free PMC Article

    06/24/2024
    The tumor suppressor NF2 modulates TEAD4 stability and activity in Hippo signaling via direct interaction.

    The tumor suppressor NF2 modulates TEAD4 stability and activity in Hippo signaling via direct interaction.
    Wu M, Hu L, He L, Yuan L, Yang L, Zhao B, Zhang L, He X., Free PMC Article

    06/6/2024
    Integrative Epigenetic and Molecular Analysis Reveals a Novel Promoter for a New Isoform of the Transcription Factor TEAD4.

    Integrative Epigenetic and Molecular Analysis Reveals a Novel Promoter for a New Isoform of the Transcription Factor TEAD4.
    Rashidiani S, Mamo G, Farkas B, Szabadi A, Farkas B, Uszkai V, Császár A, Brandt B, Kovács K, Pap M, Rauch TA., Free PMC Article

    03/13/2024
    VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification.

    VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification.
    Yang Y, Jia W, Luo Z, Li Y, Liu H, Fu L, Li J, Jiang Y, Lai J, Li H, Saeed BJ, Zou Y, Lv Y, Wu L, Zhou T, Shan Y, Liu C, Lai Y, Liu L, Hutchins AP, Esteban MA, Mazid MA, Li W., Free PMC Article

    01/30/2024
    TEAD4: A key regulator of tumor metastasis and chemoresistance - Mechanisms and therapeutic implications.

    TEAD4: A key regulator of tumor metastasis and chemoresistance - Mechanisms and therapeutic implications.
    Liu M, Hu W, Meng X, Wang B.

    01/16/2024
    High TEAD4 Expression is Associated With Aggressive Clear Cell Renal Cell Carcinoma, Regardless of YAP1 Expression.

    High TEAD4 Expression is Associated With Aggressive Clear Cell Renal Cell Carcinoma, Regardless of YAP1 Expression.
    Park MA, Lee YH, Gu MJ.

    11/14/2023
    Tea domain transcription factor TEAD4 mitigates TGF-beta signaling and hepatocellular carcinoma progression independently of YAP.

    Tea domain transcription factor TEAD4 mitigates TGF-β signaling and hepatocellular carcinoma progression independently of YAP.
    Luo W, Li Y, Zeng Y, Li Y, Cheng M, Zhang C, Li F, Wu Y, Huang C, Yang X, Kremerskothen J, Zhang J, Zhang C, Tu S, Li Z, Luo Z, Lin Z, Yan X., Free PMC Article

    08/30/2023
    TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription.

    TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription.
    Zhang H, Ren C, Liu Q, Wang Q, Wang D.

    06/2/2023
    MAD2L1 is transcriptionally regulated by TEAD4 and promotes cell proliferation and migration in colorectal cancer.

    MAD2L1 is transcriptionally regulated by TEAD4 and promotes cell proliferation and migration in colorectal cancer.
    Li Q, Tong D, Jing X, Ma P, Li F, Jiang Q, Zhang J, Wen H, Cui M, Huang C, Zhang M.

    05/19/2023
    The YAP-TEAD4 complex promotes tumor lymphangiogenesis by transcriptionally upregulating CCBE1 in colorectal cancer.

    The YAP-TEAD4 complex promotes tumor lymphangiogenesis by transcriptionally upregulating CCBE1 in colorectal cancer.
    Song J, Dang X, Shen X, Liu Y, Gu J, Peng X, Huang Z, Hong W, Cui L, Liu CY., Free PMC Article

    05/17/2023
    Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP/TEAD4/ACADL axis in hepatocellular carcinoma.

    Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP/TEAD4/ACADL axis in hepatocellular carcinoma.
    Cai J, Chen T, Jiang Z, Yan J, Ye Z, Ruan Y, Tao L, Shen Z, Liang X, Wang Y, Xu J, Cai X., Free PMC Article

    05/15/2023
    CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis.

    CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis.
    Guo Y, Zhu Z, Huang Z, Cui L, Yu W, Hong W, Zhou Z, Du P, Liu CY., Free PMC Article

    09/3/2022
    TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryo.

    TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryo.
    Stamatiadis P, Cosemans G, Boel A, Menten B, De Sutter P, Stoop D, Chuva de Sousa Lopes SM, Lluis F, Coucke P, Heindryckx B.

    08/13/2022
    TAZ promotes vasculogenic mimicry in gastric cancer through the upregulation of TEAD4.

    TAZ promotes vasculogenic mimicry in gastric cancer through the upregulation of TEAD4.
    Zhang Y, Bai J, Cheng R, Zhang D, Qiu Z, Liu T, Che N, Dong X, Zhao N, Lin X, Liang X, Li F, Li Y, Sun B, Zhao X.

    04/16/2022
    TEAD4 overexpression suppresses thyroid cancer progression and metastasis in vitro by modulating Wnt signaling.

    TEAD4 overexpression suppresses thyroid cancer progression and metastasis in vitro by modulating Wnt signaling.
    Zhang B, Wang Q, Ji Y, Zhang X, Xue L, Shi Q, Li J.

    04/16/2022
    Pan-cancer analysis, cell and animal experiments revealing TEAD4 as a tumor promoter in ccRCC.

    Pan-cancer analysis, cell and animal experiments revealing TEAD4 as a tumor promoter in ccRCC.
    Li F, Feng Y, Jiang Q, Zhang J, Wu F, Li Q, Jing X, Wang X, Huang C.

    02/26/2022
    Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications.

    Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications.
    Mesrouze Y, Meyerhofer M, Zimmermann C, Fontana P, Erdmann D, Chène P., Free PMC Article

    02/5/2022
    The transcription factor TEAD4 enhances lung adenocarcinoma progression through enhancing PKM2 mediated glycolysis.

    The transcription factor TEAD4 enhances lung adenocarcinoma progression through enhancing PKM2 mediated glycolysis.
    Hu Y, Mu H, Deng Z.

    01/22/2022
    HOXB13 suppresses proliferation, migration and invasion, and promotes apoptosis of gastric cancer cells through transcriptional activation of VGLL4 to inhibit the involvement of TEAD4 in the Hippo signaling pathway.

    HOXB13 suppresses proliferation, migration and invasion, and promotes apoptosis of gastric cancer cells through transcriptional activation of VGLL4 to inhibit the involvement of TEAD4 in the Hippo signaling pathway.
    Geng H, Liu G, Hu J, Li J, Wang D, Zou S, Xu X., Free PMC Article

    01/15/2022
    TEA domain transcription factor 4 modulates repression of fetal haemoglobin by direct binding to the gamma-globin gene promoters.

    TEA domain transcription factor 4 modulates repression of fetal haemoglobin by direct binding to the γ-globin gene promoters.
    Lin J, Ye Y, Shang X, Zhang Y, Wei X, Xu X.

    01/8/2022
    The interaction of TEA domain transcription factor 4 (TEAD4) and Yes-associated protein 1 (YAP1) promoted the malignant process mediated by serum/glucocorticoid regulated kinase 1 (SGK1).

    The interaction of TEA domain transcription factor 4 (TEAD4) and Yes-associated protein 1 (YAP1) promoted the malignant process mediated by serum/glucocorticoid regulated kinase 1 (SGK1).
    He S, Zhang H, Xiao Z, Bhushan S, Gao K, Wang W., Free PMC Article

    11/13/2021
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