| Transcobalamin 2 orchestrates monocyte proliferation and TLR4-driven inflammation in systemic lupus erythematosus via folate one-carbon metabolism. | Transcobalamin 2 orchestrates monocyte proliferation and TLR4-driven inflammation in systemic lupus erythematosus via folate one-carbon metabolism.
Liu B, Li A, Liu Y, Zhou X, Xu J, Zuo X, Xue K, Cui Y., Free PMC Article | 10/18/2024 |
| Innovative biomarkers TCN2 and LY6E can significantly inhibit respiratory syncytial virus infection. | Innovative biomarkers TCN2 and LY6E can significantly inhibit respiratory syncytial virus infection.
Cao B, Li M, Li X, Ji X, Wan L, Jiang Y, Zhou L, Gong F, Chen X., Free PMC Article | 10/1/2024 |
| "Progressive myoclonic ataxia and developmental/epileptic encephalopathy associated with a novel homozygous mutation in TCN2 gene". | "Progressive myoclonic ataxia and developmental/epileptic encephalopathy associated with a novel homozygous mutation in TCN2 gene".
Oshi MAM, Alfaifi J, Alqahtani YAM, Aljabri MF, Kamal NM, Althopaity J, Althobaiti KA, Almalki AM, Abosabie SAS, Abosabie SA, Sherbiny HS, Almanjoomi SK, Abdallah EAA., Free PMC Article | 02/7/2024 |
| Folate metabolizing gene polymorphisms and genetic vulnerability to preterm birth in Korean women. | Folate metabolizing gene polymorphisms and genetic vulnerability to preterm birth in Korean women.
Kwon BN, Lee NR, Kim HJ, Kang YD, Kim JS, Park JW, Jin HJ. | 02/26/2022 |
| Transcobalamin II deficiency in twins with a novel variant in the TCN2 gene: case report and review of literature. | Transcobalamin II deficiency in twins with a novel variant in the TCN2 gene: case report and review of literature.
Kose E, Besci O, Gudeloglu E, Suncak S, Oymak Y, Ozen S, Isguder R. | 08/28/2021 |
| Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter. | Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter.
Boachie J, Adaikalakoteswari A, Goljan I, Samavat J, Cagampang FR, Saravanan P., Free PMC Article | 04/24/2021 |
| Relationship between cobalt transporter II gene rs9606756 site mutant and serum homocysteine level and recurrent cerebral infarction in young and middle-aged people. | Relationship between cobalt transporter II gene rs9606756 site mutant and serum homocysteine level and recurrent cerebral infarction in young and middle-aged people.
Liu J, Jiang Y, Liu D, Zhang H, Chen T, Zhang G, Liu H, DU S, Lin Z, Jin Y, Li X. | 04/17/2021 |
| 3'-UTR Polymorphisms of Vitamin B-Related Genes Are Associated with Osteoporosis and Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women. | 3'-UTR Polymorphisms of Vitamin B-Related Genes Are Associated with Osteoporosis and Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women.
Ahn TK, Kim JO, An HJ, Park HS, Choi UY, Sohn S, Kim KT, Kim NK, Han IB., Free PMC Article | 03/20/2021 |
| Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure. | Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure.
Liu S, Liu M, Li Q, Liu X, Wang Y, Mambiya M, Zhang K, Yang L, Zhang Q, Shang M, Zeng F, Nie F, Liu W., Free PMC Article | 09/26/2020 |
| A decreased risk of cleft for children carrying the 667G allele at TCN2 gene (P = 0.02). | Association between oral cleft and transcobalamin 2 polymorphism in a sample study from Nassiriya, Iraq.
Carinci F, Palmieri A, Scapoli L, Cura F, Abenavoli F, Giannì AB, Russillo A, Docimo R, Martinelli M., Free PMC Article | 03/21/2020 |
| In genotype combination analysis, two combinations containing the TCN2 67 polymorphism AG type were associated with RIF risk. Our study showed that the polymorphisms of TCN2 and TCblR are associated with RIF and are potential genetic predisposing factors for RIF among Korean women. | Genetic polymorphisms of the cobalamin transport system are associated with idiopathic recurrent implantation failure.
Park HS, Kim JO, An HJ, Ryu CS, Ko EJ, Kim YR, Ahn EH, Lee WS, Kim JH, Kim NK., Free PMC Article | 12/14/2019 |
| 12 articles were included in this study. The pooled results did not reveal a significant association of the MTRR A66G polymorphism (G vs. A: OR = 0.99, 95% CI = 0.82-1.18, p = 0.72) with Nonsyndromic Cleft Lip With or Without Cleft Palate risk | Associations Between MTR A2756G, MTRR A66G, and TCN2 C776G Polymorphisms and Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate: A Meta-Analysis.
Lei W, Xia Y, Wu Y, Fu G, Ren A. | 12/22/2018 |
| The findings of the present case-control study did not support an association between the TCN2 rs1801198 and TCN2R rs2336573 polymorphisms and the risk of recurrent spontaneous abortion in a sample of the Iranian population. | Evaluation of transcobalamin II rs1801198 and transcobalamin II receptor rs2336573 gene polymorphisms in recurrent spontaneous abortion.
Hashemi M, Mokhtari M, Yazdani-Shahrbabaki V, Danesh H, Bizhani F, Taheri M. | 12/1/2018 |
| Genotypes of transcobalamin 2 (TCN2) rs1801198, methionine synthase (MTR) rs1805087, methionine synthase reductase (MTRR) rs1801394, and methylene tetrahydrofolate reductase (MTHFR) rs1801133 were examined in 201 children with Autism Spectrum Disorder and 200 healthy controls from the Han Chinese population. Our results showed no association of all examined SNPs with childhood ASD and its severity. | Association Study of Polymorphisms in Genes Relevant to Vitamin B12 and Folate Metabolism with Childhood Autism Spectrum Disorder in a Han Chinese Population.
Zhang Z, Yu L, Li S, Liu J., Free PMC Article | 08/18/2018 |
| Proteomics analysis of glioblastoma cell line under hypoxia identified B12 transporter protein TCN2, which is essential for one-carbon metabolism, as being significantly downregulated. TCN2 downregulation seems to play an important role in controlling cell transformation to a highly aggressive mesenchymal/cancer stem cell (CSC), whereas high expression of TCN2 can reverse it. | Proteome Analysis of Hypoxic Glioblastoma Cells Reveals Sequential Metabolic Adaptation of One-Carbon Metabolic Pathways.
Zhang K, Xu P, Sowers JL, Machuca DF, Mirfattah B, Herring J, Tang H, Chen Y, Tian B, Brasier AR, Sowers LC., Free PMC Article | 06/23/2018 |
| TCN2 (rs1801198, rs9606756) variations, as well as serum levels of Hcy, vitamin B12 and folate, are correlated with ulcerative colitis. | [Association of transcobalamine II gene polymorphisms and serum homocysteine, vitamin B(12) and folate levels with ulcerative colitis among Chinese patients].
Zheng S, Wu H, Ye F, Xia X, Xia S, Lin X, Wu X, Jiang L, Ding R, Jiang Y. | 03/17/2018 |
| tagSNPs in MTHFR, MTR, MTRR, and TCN2 were not associated with NSCLP in our study, but continued exploration, including allele frequency of various populations and molecular mechanism of the gene-gene interactions of the genes, may provide additional insight into NSCLP. | Lack of Association Between MTHFR, MTR, MTRR, and TCN2 Genes and Nonsyndromic CL±P in a Chinese Population: Case-Control Study and Meta-Analysis.
Jiang C, Yin N, Zhao Z, Wu D, Wang Y, Li H, Song T. | 01/27/2018 |
| TCN2 (rs1801198, rs9606756) polymorphisms as well as folate deficiency and vitamin B12 deficiency are correlated with Crohn's disease. | An Analysis of Transcobalamin II Gene Polymorphisms and Serum Levels of Homocysteine, Folate and Vitamin B12 in Chinese Patients with Crohn's Disease.
Zheng S, Wu C, Yang W, Xia X, Lin X, Jiang L, Ding R, Jiang Y. | 12/23/2017 |
| The rs9606756[c.67A>G,p.Ile23Val] variant from TCN2 was associated with waist circumference (WC) at nearly genome-wide significance (P = 8.92E-08). | The TCN2 variant of rs9606756 [Ile23Val] acts as risk loci for obesity-related traits and mediates by interacting with Apo-A1.
Hebbar P, Alkayal F, Nizam R, Melhem M, Elkum N, John SE, Abufarha M, Alsmadi O, Thanaraj TA. | 12/9/2017 |
| TC deficiency has a wide heterogeneity in clinical phenotype, genotype, laboratory, and radiologic findings. Early detection of the disease and early initiation of aggressive parenteral treatment is probably associated with better prognosis and disease control. | Long-term Outcome of 4 Patients With Transcobalamin Deficiency Caused by 2 Novel TCN2 Mutations.
Nashabat M, Maegawa G, Nissen PH, Nexo E, Al-Shamrani H, Al-Owain M, Alfadhel M. | 11/4/2017 |
| Meta-analysis results indicate an influence of rs1801198 on holotranscobalamin and homocysteine concentrations in European-descent subjects. | Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL., Free PMC Article | 10/14/2017 |
| TCN2 polymorphism is associated with ulcerative colitis. | Association of ulcerative colitis with transcobalamin II gene polymorphisms and serum homocysteine, vitamin B(12), and folate levels in Chinese patients.
Zheng S, Yang W, Wu C, Sun L, Lin D, Lin X, Jiang L, Ding R, Jiang Y. | 09/16/2017 |
| A novel homozygous mutation (c.1106+1516_1222+1231del) was detected in 7 patients from 5 families. A 5304-bp deletion that begins 1516 bp into intron 7 and ends 1231 bp into intron 8 was observed. The deletion includes all of exon 8 and causes a frameshift to produce a premature stop of 4 codons into the new reading frame (counting ATG as 1). | Seven Patients With Transcobalamin Deficiency Diagnosed Between 2010 and 2014: A Single-Center Experience.
Yildirim ZK, Nexo E, Rupar T, Büyükavci M. | 09/9/2017 |
| The association of the TCN2 polymorphism with peripheral neuropathy was independent of vitamin B-12 intake. | Transcobalamin 776C→G polymorphism is associated with peripheral neuropathy in elderly individuals with high folate intake.
Sawaengsri H, Bergethon PR, Qiu WQ, Scott TM, Jacques PF, Selhub J, Paul L., Free PMC Article | 06/24/2017 |
| G/G homozygosity of C776G TC2 and the C/G genotype of the C776G TC2 genegene polymorphism increases the risk of oral cancer | TC2 C776G polymorphism studies in patients with oral cancer in the Polish population.
Malinowska K, Morawiec-Sztandera A, Majsterek I, Kaczmarczyk D. | 06/3/2017 |