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    MIR634 microRNA 634 [ Homo sapiens (human) ]

    Gene ID: 693219, updated on 10-Oct-2023

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Hsa_circ_0081069 facilitates tongue squamous cell carcinoma progression by modulating MAP2K4 expression via miR-634.

    Hsa_circ_0081069 facilitates tongue squamous cell carcinoma progression by modulating MAP2K4 expression via miR-634.
    Pan C, Su Z, Xie H, Ning Y, Li S, Xiao H.

    03/23/2023
    Profiling of circular RNAs and circTPCN/miR-634/mTOR regulatory pathway in cervical cancer.

    Profiling of circular RNAs and circTPCN/miR-634/mTOR regulatory pathway in cervical cancer.
    Tian-Zhao D, Yang Y, Xing-Xuan W, Yu-Xin C, Xue-Lian W.

    07/16/2022
    miR-634 inhibits human vascular smooth muscle cell proliferation and migration in hypertension through Wnt4/beta-catenin pathway.

    miR-634 inhibits human vascular smooth muscle cell proliferation and migration in hypertension through Wnt4/β-catenin pathway.
    Niu L, Sun N, Kong L, Xu Y, Kang Y.

    01/22/2022
    LncRNA SNHG8 promotes cell migration and invasion in breast cancer cell through miR-634/ZBTB20 axis.

    LncRNA SNHG8 promotes cell migration and invasion in breast cancer cell through miR-634/ZBTB20 axis.
    Fan D, Qiu B, Yang XJ, Tang HL, Peng SJ, Yang P, Dong YM, Yang L, Bao GQ, Zhao HD.

    07/3/2021
    Downregulation of long non-coding RNA ZXF1 restricts cell survival by targeting miR-634-GRB2 in lung adenocarcinoma.

    Downregulation of long non-coding RNA ZXF1 restricts cell survival by targeting miR-634-GRB2 in lung adenocarcinoma.
    Ren X, Xu N, Zhang Y, Wang T.

    11/21/2020
    This study showed that hsa_circ_0001742 could promote tongue squamous cell carcinoma progression by targeting miR-634/RAB1A pathway.

    Hsa_circ_0001742 promotes tongue squamous cell carcinoma progression via modulating miR-634 expression.
    Shao B, He L.

    03/28/2020
    The expression level of miR-634 in gastric cancer tissues and cell lines was lower than that in normal adjacent tissues and control cells. The survival of cells was decreased, and number of cells migrating and invading was decreased in the miR-634 mimics group. Over-expression of miR-634 inhibited the proliferation, migration, and invasion of gastric cancer cell lines.

    Expression of miR-634 in gastric carcinoma and its effects on proliferation, migration, and invasion of gastric cancer cells.
    Guo J, Zhang CD, An JX, Xiao YY, Shao S, Zhou NM, Dai DQ., Free PMC Article

    07/6/2019
    he present study demonstrated that DANCR/miR-634/RAB1A axis plays crucial roles in the progression of glioma, and DANCR might potentially serve as a therapeutic target for the treatment of glioma patients.

    LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma.
    Xu D, Yu J, Gao G, Lu G, Zhang Y, Ma P., Free PMC Article

    08/18/2018
    MiR-634 is one of the few characterized examples of Pol-III-dependent intronic miRNAs.

    miR-634 is a Pol III-dependent intronic microRNA regulating alternative-polyadenylated isoforms of its host gene PRKCA.
    Paraboschi EM, Cardamone G, Rimoldi V, Duga S, Soldà G, Asselta R.

    10/28/2017
    In clinical samples, the expression of Rab1A or DHX33 was reversely correlated with miR-634. Re-expression of Rab1A or DHX33 abrogated the miR-634-mediated inhibition of cell proliferation and migration. Collectively, our data suggest a tumor suppressor role of miR-634 in hepatocellular carcinoma.

    miR-634 exhibits anti-tumor activities toward hepatocellular carcinoma via Rab1A and DHX33.
    Zhang CZ, Cao Y, Fu J, Yun JP, Zhang MF., Free PMC Article

    09/30/2017
    Findings indicate that 3' utranslated regions (3'UTR) of PIK3R1, which encodes class I PI3K regulatory subunit 1 (alpha), contained the microRNA miR-634 seed sites sequences.

    Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1.
    Cui X, Wang S, Cai H, Lin Y, Zheng X, Zhang B, Xia C., Free PMC Article

    01/28/2017
    by targeting mTOR signal pathway, miR-634 inhibited cell proliferation, migration and invasiveness in cervical cancer cells and the block of miR-634 enhances the mTOR expression at both the mRNA and protein levels which regulated the expression of mTOR negatively.

    MiR-634 decreases cell proliferation and induces apoptosis by targeting mTOR signaling pathway in cervical cancer cells.
    Cong J, Liu R, Wang X, Jiang H, Zhang Y.

    01/14/2017
    miR-634 mimics induced a proinflammatory phenotype in monocyte-derived macrophages, with enhanced expression and release of ADAM17 and IL-6 in Proteinase-3 ANCA-Associated Vasculitis

    Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis.
    Bertram A, Lovric S, Engel A, Beese M, Wyss K, Hertel B, Park JK, Becker JU, Kegel J, Haller H, Haubitz M, Kirsch T., Free PMC Article

    02/27/2016
    Overexpression of miR-634 activates the mitochondrial apoptotic pathway by direct concurrent targeting of genes associated with mitochondrial homeostasis, antiapoptosis, antioxidant ability, and autophagy.

    miR-634 Activates the Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced Cytotoxicity.
    Fujiwara N, Inoue J, Kawano T, Tanimoto K, Kozaki K, Inazawa J.

    01/16/2016
    In xenograft mouse model, miR-634 inhibited tumor growth and enhanced paclitaxel sensitivity.

    MiR-634 sensitizes nasopharyngeal carcinoma cells to paclitaxel and inhibits cell growth both in vitro and in vivo.
    Peng X, Cao P, He D, Han S, Zhou J, Tan G, Li W, Yu F, Yu J, Li Z, Cao K., Free PMC Article

    07/25/2015
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