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    TCF4 transcription factor 4 [ Homo sapiens (human) ]

    Gene ID: 6925, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    MALAT1/miR-7-5p/TCF4 Axis Regulating Menstrual Blood Mesenchymal Stem Cells Improve Thin Endometrium Fertility by the Wnt Signaling Pathway.

    MALAT1/miR-7-5p/TCF4 Axis Regulating Menstrual Blood Mesenchymal Stem Cells Improve Thin Endometrium Fertility by the Wnt Signaling Pathway.
    Wang H, Chen K, Zong L, Zhao X, Wang J, Fan S, Shen B, Zheng S., Free PMC Article

    10/30/2024
    Circ_0004674 regulation of glycolysis and proliferation mechanism of osteosarcoma through miR-140-3p/TCF4 pathway.

    Circ_0004674 regulation of glycolysis and proliferation mechanism of osteosarcoma through miR-140-3p/TCF4 pathway.
    Ma Y, Du S, Wang S, Liu X, Cong L, Shen W, Ye K.

    10/29/2024
    CTG18.1 expansion in transcription factor 4 (TCF4) in corneal graft failure: preliminary study.

    CTG18.1 expansion in transcription factor 4 (TCF4) in corneal graft failure: preliminary study.
    Westin IM, Viberg A, Golovleva I, Byström B., Free PMC Article

    09/30/2024
    Deciphering novel TCF4-driven mechanisms underlying a common triplet repeat expansion-mediated disease.

    Deciphering novel TCF4-driven mechanisms underlying a common triplet repeat expansion-mediated disease.
    Bhattacharyya N, Chai N, Hafford-Tear NJ, Sadan AN, Szabo A, Zarouchlioti C, Jedlickova J, Leung SK, Liao T, Dudakova L, Skalicka P, Parekh M, Moghul I, Jeffries AR, Cheetham ME, Muthusamy K, Hardcastle AJ, Pontikos N, Liskova P, Tuft SJ, Davidson AE., Free PMC Article

    08/15/2024
    DNA methylation episignature and comparative epigenomic profiling for Pitt-Hopkins syndrome caused by TCF4 variants.

    DNA methylation episignature and comparative epigenomic profiling for Pitt-Hopkins syndrome caused by TCF4 variants.
    van der Laan L, Lauffer P, Rooney K, Silva A, Haghshenas S, Relator R, Levy MA, Trajkova S, Huisman SA, Bijlsma EK, Kleefstra T, van Bon BW, Baysal Ö, Zweier C, Palomares-Bralo M, Fischer J, Szakszon K, Faivre L, Piton A, Mesman S, Hochstenbach R, Elting MW, van Hagen JM, Plomp AS, Mannens MMAM, Alders M, van Haelst MM, Ferrero GB, Brusco A, Henneman P, Sweetser DA, Sadikovic B, Vitobello A, Menke LA., Free PMC Article

    07/24/2024
    Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy.

    Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy.
    Honda T, Nakagawa T, Yuasa T, Tokuda Y, Nakano M, Tashiro K, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Yamamoto K, Koizumi N, Okumura N., Free PMC Article

    07/16/2024
    Transcription factor 4 promotes increased corneal endothelial cellular migration by altering microtubules in Fuchs endothelial corneal dystrophy.

    Transcription factor 4 promotes increased corneal endothelial cellular migration by altering microtubules in Fuchs endothelial corneal dystrophy.
    Yan J, Mehta S, Patel K, Dhupar N, Little N, Ong Tone S., Free PMC Article

    05/24/2024
    AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.

    AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.
    Liao R, Chen X, Cao Q, Bai L, Ma C, Dai Z, Dong C., Free PMC Article

    05/14/2024
    Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.

    Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.
    Jiang Y, Gruszka D, Zeng C, Swindell WR, Gaskill C, Sorensen C, Brown W, Gangwar RS, Tsoi LC, Webster J, Sigurðardóttir SL, Sarkar MK, Uppala R, Kidder A, Xing X, Plazyo O, Xing E, Billi AC, Maverakis E, Kahlenberg JM, Gudjonsson JE, Ward NL., Free PMC Article

    05/7/2024
    TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons.

    TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons.
    Davis BA, Chen HY, Ye Z, Ostlund I, Tippani M, Das D, Sripathy SR, Wang Y, Martin JM, Shim G, Panchwagh NM, Moses RL, Farinelli F, Bohlen JF, Li M, Luikart BW, Jaffe AE, Maher BJ.,

    03/18/2024
    USP10 promotes the progression of triple-negative breast cancer by enhancing the stability of TCF4 protein.

    USP10 promotes the progression of triple-negative breast cancer by enhancing the stability of TCF4 protein.
    Yang JR, Lu YB, Su HX, Xiao Y, Pan Q, Su F, Zhang XB, Zhu KL, Guan QL, Ling XL.

    12/6/2023
    The TCF4 Trinucleotide Repeat Expansion of Fuchs' Endothelial Corneal Dystrophy: Implications for the Anterior Segment of the Eye.

    The TCF4 Trinucleotide Repeat Expansion of Fuchs' Endothelial Corneal Dystrophy: Implications for the Anterior Segment of the Eye.
    Hu J, Gong X, Johnson ST, Corey DR, Mootha VV., Free PMC Article

    05/26/2023
    Protein stabilization of ITF2 by NF-kappaB prevents colitis-associated cancer development.

    Protein stabilization of ITF2 by NF-κB prevents colitis-associated cancer development.
    Lee M, Kim YS, Lim S, Shin SH, Kim I, Kim J, Choi M, Kim JH, Koh SJ, Park JW, Shin HW., Free PMC Article

    05/24/2023
    A combination of genetic mapping and retroillumination photography was used to quantify the severity of the disease phenotype associated with FCD2 and to compare it to the disease characteristics of FCD1.

    Age-severity relationships in families linked to FCD2 with retroillumination photography.
    McGlumphy EJ, Yeo WS, Riazuddin SA, Al-Saif A, Wang J, Eghrari AO, Meadows DN, Emmert DG, Katsanis N, Gottsch JD., Free PMC Article

    03/17/2023
    TF and TCF4 gene polymorphisms are linked to autism spectrum disorder: a case-control study.

    TF and TCF4 gene polymorphisms are linked to autism spectrum disorder: a case-control study.
    Azmerin M, Hussain MS, Aziz MA, Barek MA, Begum M, Sen N, Rahman MA, Shahriar M, Baeesa SS, Ashraf GM, Islam MS., Free PMC Article

    12/3/2022
    The recurrent TCF4 missense variant p.(Arg389Cys) causes a neurodevelopmental disorder overlapping with but not typical for Pitt-Hopkins syndrome.

    The recurrent TCF4 missense variant p.(Arg389Cys) causes a neurodevelopmental disorder overlapping with but not typical for Pitt-Hopkins syndrome.
    Popp B, Bienvenu T, Giurgea I, Metreau J, Kraus C, Reis A, Fischer J, Bralo MP, Tenorio-Castaño J, Lapunzina P, Almoguera B, Lopez-Grondona F, Sticht H, Zweier C., Free PMC Article

    11/5/2022
    Genetic Polymorphisms in miR-137 and Its Target Genes, TCF4 and CACNA1C, Contribute to the Risk of Bipolar Disorder: A Preliminary Case-Control Study and Bioinformatics Analysis.

    Genetic Polymorphisms in miR-137 and Its Target Genes, TCF4 and CACNA1C, Contribute to the Risk of Bipolar Disorder: A Preliminary Case-Control Study and Bioinformatics Analysis.
    Mokhtari MA, Sargazi S, Saravani R, Heidari Nia M, Mirinejad S, Hadzsiev K, Bene J, Shakiba M., Free PMC Article

    10/15/2022
    Transcription factor 4 expression and correlation with tumor progression in gallbladder cancer.

    Transcription factor 4 expression and correlation with tumor progression in gallbladder cancer.
    Neogi K, Tewari M, Singh AK, Sharma K, Tej GNVC, Verma SS, Gupta SC, Nayak PK.

    08/6/2022
    TCF4 trinucleotide repeat expansion in Swedish cases with Fuchs' endothelial corneal dystrophy.

    TCF4 trinucleotide repeat expansion in Swedish cases with Fuchs' endothelial corneal dystrophy.
    Viberg A, Westin IM, Golovleva I, Byström B.

    07/16/2022
    An Osteoporosis Susceptibility Allele at 11p15 Regulates SOX6 Expression by Modulating TCF4 Chromatin Binding.

    An Osteoporosis Susceptibility Allele at 11p15 Regulates SOX6 Expression by Modulating TCF4 Chromatin Binding.
    Zhu DL, Chen XF, Zhou XR, Hu SY, Tuo XM, Hao RH, Dong SS, Jiang F, Rong Y, Yang TL, Yang Z, Guo Y.

    06/18/2022
    Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content.

    Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content.
    Papes F, Camargo AP, de Souza JS, Carvalho VMA, Szeto RA, LaMontagne E, Teixeira JR, Avansini SH, Sánchez-Sánchez SM, Nakahara TS, Santo CN, Wu W, Yao H, Araújo BMP, Velho PENF, Haddad GG, Muotri AR., Free PMC Article

    05/14/2022
    Circ_0005526 contributes to interleukin-1beta-induced chondrocyte injury in osteoarthritis via upregulating transcription factor 4 by interacting with miR-142-5p.

    Circ_0005526 contributes to interleukin-1β-induced chondrocyte injury in osteoarthritis via upregulating transcription factor 4 by interacting with miR-142-5p.
    Wahafu P, Xu A, Zhao B, Tuo Y, Yang J., Free PMC Article

    05/7/2022
    Disruption and deletion of the proximal part of TCF4 are associated with mild intellectual disability: About three new patients.

    Disruption and deletion of the proximal part of TCF4 are associated with mild intellectual disability: About three new patients.
    Masson J, Pons L, Busa T, Missirian C, Lines M, Tevissen H, Diguet F, Rollat-Farnier PA, Lesca G, Sanlaville D, Schluth-Bolard C.

    04/9/2022
    Epilepsy, electroclinical features, and long-term outcomes in Pitt-Hopkins syndrome due to pathogenic variants in the TCF4 gene.

    Epilepsy, electroclinical features, and long-term outcomes in Pitt-Hopkins syndrome due to pathogenic variants in the TCF4 gene.
    Matricardi S, Bonanni P, Iapadre G, Elia M, Cesaroni E, Danieli A, Negrin S, Zagaroli L, Operto FF, Carotenuto M, Pisani F, Turco EC, Orsini A, Bonuccelli A, Savasta S, Concolino D, Di Cara G, Striano P, Verrotti A.

    04/9/2022
    RBM24 exacerbates bladder cancer progression by forming a Runx1t1/TCF4/miR-625-5p feedback loop.

    RBM24 exacerbates bladder cancer progression by forming a Runx1t1/TCF4/miR-625-5p feedback loop.
    Yin YW, Liu KL, Lu BS, Li W, Niu YL, Zhao CM, Yang Z, Guo PY, Qi JC., Free PMC Article

    03/26/2022
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