| Data suggest that SIGNR1(CD209b) expressed in Lewis lung cancer cell-educated macrophages appears to mediate IL-4-induced RAW264.7 macrophage polarization and thus facilitate lung cancer evasion. | Lewis Lung Cancer Cells Promote SIGNR1(CD209b)-Mediated Macrophages Polarization Induced by IL-4 to Facilitate Immune Evasion.
Yan X, Li W, Pan L, Fu E, Xie Y, Chen M, Mu D. | 12/17/2016 |
| SIGNR1-mediated phagocytosis but not SIGNR1-mediated endocytosis and cell adhesion, suppresses the TLR4-mediated production of specific proinflammatory cytokines via PI3 kinase signaling. | SIGNR1-mediated phagocytosis, but not SIGNR1-mediated endocytosis or cell adhesion, suppresses LPS-induced secretion of IL-6 from murine macrophages.
Kawauchi Y, Takagi H, Hanafusa K, Kono M, Yamatani M, Kojima N. | 02/6/2016 |
| The subtle carbohydrate preference of SIGNR1 as a phagocytic receptor or as an adhesion molecule is altered depending on the function. | Comparison of the carbohydrate preference of SIGNR1 as a phagocytic receptor with the preference as an adhesion molecule.
Kawauchi Y, Kuroda Y, Kojima N. | 10/25/2014 |
| mediates uptake of mannose-decorated particles leading to cell maturation of peritoneal DC-like cells | C-type lectin receptor SIGNR1 expressed on peritoneal phagocytic cells with an immature dendritic cell-like phenotype is involved in uptake of oligomannose-coated liposomes and subsequent cell maturation.
Kawauchi Y, Igarashi M, Kojima N. | 04/5/2014 |
| SIGNR1 is involved in the inhibition of DC maturation | Secretory IgA induces tolerogenic dendritic cells through SIGNR1 dampening autoimmunity in mice.
Diana J, Moura IC, Vaugier C, Gestin A, Tissandie E, Beaudoin L, Corthésy B, Hocini H, Lehuen A, Monteiro RC. | 11/16/2013 |
| SIGN-R1 in the MZ rapidly accelerates C3 deposition on circulating apoptotic cells by interacting with C1q, thus promoting the systemic clearance of apoptotic cells and maintaining immune tolerance in vivo. | SIGN-R1, a C-type lectin, enhances apoptotic cell clearance through the complement deposition pathway by interacting with C1q in the spleen.
Prabagar MG, Do Y, Ryu S, Park JY, Choi HJ, Choi WS, Yun TJ, Moon J, Choi IS, Ko K, Ko K, Young Shin C, Cheong C, Kang YS., Free PMC Article | 09/14/2013 |
| These results indicate that murine SIGNR1 recognizes C. albicans/yeast through a specificity partly distinct from that of its homologue human DC-SIGN. | Difference in fine specificity to polysaccharides of Candida albicans mannoprotein between mouse SIGNR1 and human DC-SIGN.
Takahara K, Arita T, Tokieda S, Shibata N, Okawa Y, Tateno H, Hirabayashi J, Inaba K., Free PMC Article | 06/16/2012 |
| enhances TNF-alpha production by macrophages in cooperation with TLR2 upon microbial recognition | Efficient capture of Candida albicans and zymosan by SIGNR1 augments TLR2-dependent TNF-α production.
Takahara K, Tokieda S, Nagaoka K, Inaba K. | 06/9/2012 |
| Toll-like receptor 2-mediated signalling is negatively regulated by SIGNR1-mediated signalling in dendritic cells, possibly through suppressor of cytokine signalling-1-mediated degradation of the MyD88-adaptor-like protein. | Involvement of suppressor of cytokine signalling-1-mediated degradation of MyD88-adaptor-like protein in the suppression of Toll-like receptor 2-mediated signalling by the murine C-type lectin SIGNR1-mediated signalling.
Ohtani M, Iyori M, Saeki A, Tanizume N, Into T, Hasebe A, Totsuka Y, Shibata K. | 06/2/2012 |
| SIGNR1 was shown to enhance the intracellular oxidative burst of macrophages in response to heat killed C. albicans in cooperation with Dectin-1. | C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1.
Takahara K, Tokieda S, Nagaoka K, Takeda T, Kimura Y, Inaba K. | 06/25/2011 |
| sugar-modified antigens might be used to induce oral tolerance by targeting SIGNR1 and dendritic cells in the gastrointestinal lamina propria (LPDCs). | Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1.
Zhou Y, Kawasaki H, Hsu SC, Lee RT, Yao X, Plunkett B, Fu J, Yang K, Lee YC, Huang SK., Free PMC Article | 11/6/2010 |
| These results show that cross-linking of SIGNR1 triggers phosphorylation of SFKs, which leads to activation of the JNK pathway and induction of TNF-alpha production in macrophage-like RAW264.7 cells. | Cross-linking of SIGNR1 activates JNK and induces TNF-alpha production in RAW264.7 cells that express SIGNR1.
Numazaki M, Kato C, Kawauchi Y, Kajiwara T, Ishii M, Kojima N. | 01/21/2010 |
| This study highlights the finding that although there was binding of SIGNR1 to immunogenic factors produced in the S. mansoni life cycle, this recognition does not translate to a functional in vivo role for the PRR during infection. | The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection.
Saunders SP, Walsh CM, Barlow JL, Mangan NE, Taylor PR, McKenzie AN, Smith P, Fallon PG., Free PMC Article | 01/21/2010 |
| Antigens are presented by SIGNR1 expressed by marginal zone macrophages to the developing marginal zone B cell population thereby influencing the repertoire of this B cell population, which is pivotal for the early immune response. | Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae.
Koppel EA, Litjens M, van den Berg VC, van Kooyk Y, Geijtenbeek TB. | 01/21/2010 |
| data suggest that although SIGNR1 has a similar binding specificity as DC-SIGN, its role is limited during murine M. tuberculosis infection | Mice lacking SIGNR1 have stronger T helper 1 responses to Mycobacterium tuberculosis.
Wieland CW, Koppel EA, den Dunnen J, Florquin S, McKenzie AN, van Kooyk Y, van der Poll T, Geijtenbeek TB. | 01/21/2010 |
| Recognizes pathogens and contributes to innate immunity. | [Natural selection of DC-SIGN and its homologues L-SIGN and mSIGNR1 in pathogen recognition and innate immunity].
Quintana-Murci L. | 01/21/2010 |
| isolation of a murine homologue of DC-SIGN that is identical to the previously reported murine homologue mSIGNR1; expressed in marginal zone macrophages | Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo.
Geijtenbeek TB, Groot PC, Nolte MA, van Vliet SJ, Gangaram-Panday ST, van Duijnhoven GC, Kraal G, van Oosterhout AJ, van Kooyk Y. | 01/21/2010 |
| Dendritic cell-specific ICAM-3-grabbing nonintegrin homolog SIGNR1 has been identified as a major mannose receptor for fungal and other pathogens present on murine resident peritoneal macrophages. | The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages.
Taylor PR, Brown GD, Herre J, Williams DL, Willment JA, Gordon S. | 01/21/2010 |