| Genome-wide association study implicates the role of TBXAS1 in the pathogenesis of depressive symptoms among the Korean population. | Genome-wide association study implicates the role of TBXAS1 in the pathogenesis of depressive symptoms among the Korean population.
Park K, Do AR, Chung Y, Kim MJ, Rhee SJ, Yoon DH, Choi SH, Cho SJ, Kim HN, Ahn YM, Won S., Free PMC Article | 02/14/2024 |
| TBXAS1 Gene Polymorphism Is Associated with the Risk of Ischemic Stroke of Metabolic Syndrome in a Chinese Han Population. | TBXAS1 Gene Polymorphism Is Associated with the Risk of Ischemic Stroke of Metabolic Syndrome in a Chinese Han Population.
Peng J, Lu F, Zhong M, Zhao Y, Wang Z, Zhang W., Free PMC Article | 08/13/2022 |
| Novel TBXAS1 variants in two Indian children with Ghosal hematodiaphyseal dysplasia: A concise report. | Novel TBXAS1 variants in two Indian children with Ghosal hematodiaphyseal dysplasia: A concise report.
Sudhakar M, Sharma M, Kandasamy S, Gummadi A, Rawat A, Vignesh P. | 06/18/2022 |
| Novel compound heterozygous variants of TBXAS1 presenting with Ghosal hematodiaphyseal dysplasia treated with steroids. | Novel compound heterozygous variants of TBXAS1 presenting with Ghosal hematodiaphyseal dysplasia treated with steroids.
Kim SY, Ing A, Gong S, Yap KL, Bhat R., Free PMC Article | 12/11/2021 |
| A new insight into subinteractomes of functional antagonists: Thromboxane (CYP5A1) and prostacyclin (CYP8A1) synthases. | A new insight into subinteractomes of functional antagonists: Thromboxane (CYP5A1) and prostacyclin (CYP8A1) synthases.
Ershov PV, Yablokov E, Zgoda V, Mezentsev Y, Gnedenko O, Kaluzhskiy L, Svirid A, Gilep A, Usanov SA, Ivanov A. | 11/27/2021 |
| Ghosal hematodiaphyseal dysplasia and response to corticosteroid therapy. | Ghosal hematodiaphyseal dysplasia and response to corticosteroid therapy.
Joy P, Yoganathan S, Korula S, Abraham SSC, Barney AM, Walter VM, Gibikote S, Danda S. | 07/10/2021 |
| Thromboxane A synthase 1 gene expression and promotor haplotypes are associated with risk of large artery-atherosclerosis stroke in Iranian population. | Thromboxane A synthase 1 gene expression and promotor haplotypes are associated with risk of large artery-atherosclerosis stroke in Iranian population.
Ramazi S, Heydari-Zarnagh H, Goudarzian M, Khalaj-Kondori M, Bonyadi M. | 09/12/2020 |
| The available theoretical and experimental data have elucidated the very important role of the thromboxane A2 - thromboxane A synthase - thromboxane A2 receptor axis in the pathogenesis of thrombotic diseases. Systematic studies are required to verify genetic markers in patients at high cardiovascular risk, in order to achieve more effective diagnostics and treatment. [review] | Thromboxane A Synthase: A New Target for the Treatment of Cardiovascular Diseases.
Mesitskaya DF, Syrkin AL, Aksenova MG, Zhang Y, Zamyatnin AA Jr, Kopylov PY. | 03/9/2019 |
| RS41708TT is not only independent risk factor for symptomatic carotid artery or intracranial arterial stenosis, but is also independent risk predictor for neurologic deterioration in ischemic stroke patients. | Variants in COX-2, PTGIS, and TBXAS1 Are Associated with Carotid Artery or Intracranial Arterial Stenosis and Neurologic Deterioration in Ischemic Stroke Patients.
Yi X, Ming B, Wang C, Chen H, Ma C. | 12/16/2017 |
| Sequencing revealed two novel biallelic variants of unknown significance within the thromboxane A synthase gene, TBXAS1 (c.266T > C; c.989T > C), bioinformatically predicted to disrupt the protein. TBXAS1 mutations result in Ghosal hematodiaphyseal dysplasia (OMIM 231095), the autosomal recessive syndrome associated with abnormal bone structure and BMF. | Chronic steroid-response pancytopenia and increased bone density due to thromboxane synthase deficiency.
Sharma R, Sierra Potchanant E, Schwartz JE, Nalepa G. | 12/2/2017 |
| TXAS1 rs2267679TT and rs41708TT genotypes are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients. | Genetic variants of PTGS2, TXA2R and TXAS1 are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients.
Yi X, Lin J, Luo H, Wang C, Liu Y., Free PMC Article | 10/7/2017 |
| the administration of salted drinking water (2.7% NaCl) to wild-type mice resulted in elevated placental TXA2 synthase (TXAS) and plasma thromboxane A2, but not prostacyclin, levels, which was also found in clinical preeclampsia placenta samples. | Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy.
Pai CH, Yen CT, Chen CP, Yu IS, Lin SW, Lin SR., Free PMC Article | 08/13/2016 |
| Single nucleotide polymorphisms of TBXAS1 are associated with susceptibility to gout in ethnic Han males population. | [Association of single nucleotide polymorphisms of cytochrome P450 gene with susceptibility to gout in ethnic Han males from coastal regions of Shandong province].
Han L, Mao G, Chen Y, Li C, Liu Z, Wang Y, Li X, Sun M, Ren W, Wang X, Jia Z. | 11/21/2015 |
| The cardiovascular events significantly morefrequently occurred during 12 and 18 months in resistant diabetics and in the patients with an allele lacking the *2/*3 CYP2C9 gene function and AT/TT polymorphism of the thromboxane synthase gene TBS1. | [CLINICAL AND PHARMACOLOGICAL FACTORS INFLUENCING RESISTANCE TO CLOPIDOGREL IN PATIENTS WITH CARDIOVASCULAR DISEASES].
Mesitskaia DF, Nikitina IuM, Kopylov FIu, Syrkin AL, Aksenova MG, Kirillov MIu, Dobrovol'skiĭ AV. | 08/29/2015 |
| The carriage of Thromboxane A synthase 1 gene polymorphism AA was shown to affect the risk of clopidogrel resistance. | [Positive effect of low-activity thromboxane A synthase gene on prognosis in coronary heart disease].
Kopylov FY, Mesitskaya DF, Nikitina YM, Aksenova MG, Dobrovolsky AV, Lomakin OV, Chernyi OV. | 07/25/2015 |
| study suggests that the anti-tumor effect of glycyrrhizin in lung adenocarcinoma is, at least in part, TxAS-dependent. | Glycyrrhizin suppresses lung adenocarcinoma cell growth through inhibition of thromboxane synthase.
Huang RY, Chu YL, Jiang ZB, Chen XM, Zhang X, Zeng X. | 10/18/2014 |
| 12-HHT is produced by both TxAS-dependent and TxAS-independent pathways in vitro and in vi | Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand.
Matsunobu T, Okuno T, Yokoyama C, Yokomizo T., Free PMC Article | 05/17/2014 |
| In this study we have showed, for the first time, a significant role of the minor allele rs6962291 of TBXAS1 in patients with NSAID acute cutaneous hypersensitivity. | Association of thromboxane A1 synthase (TBXAS1) gene polymorphism with acute urticaria induced by nonsteroidal anti-inflammatory drugs.
Vidal C, Porras-Hurtado L, Cruz R, Quiralte J, Cardona V, Colás C, Castillo LF, Marcos C, Soto T, Lopez-Abad R, Hernández D, Audicana MT, Armisén M, Rodríguez V, Perez-Carral C, Moreno E, Cabañes R, Corominas M, Parra A, Lobera T, Quiñones D, Ojeda P, Luna I, Torres M, Carracedo A. | 12/14/2013 |
| The increased Km and decreased Vmax values observed with L357V suggest that this variant may generate less TXA2 at the low levels of PGH2 expected in vivo, raising the possibility of attenuated signaling through the thromboxane pathway. | Functional analysis of human thromboxane synthase polymorphic variants.
Chen CY, Poole EM, Ulrich CM, Kulmacz RJ, Wang LH., Free PMC Article | 03/30/2013 |
| Data show that that DNA methylation of the TBXAS1 promoter was decreased and thromboxane synthase expression was increased in omental arteries of preeclamptic women as compared with normal pregnant women. | Reduced methylation of the thromboxane synthase gene is correlated with its increased vascular expression in preeclampsia.
Mousa AA, Strauss JF 3rd, Walsh SW., Free PMC Article | 07/28/2012 |
| these results showed that visfatin promoted IL-8 production by upregulation of TXAS, leading to angiogenic activation in endothelial cells. | Upregulation of thromboxane synthase mediates visfatin-induced interleukin-8 expression and angiogenic activity in endothelial cells.
Kim SR, Jung YH, Park HJ, Kim MK, Jeong JW, Jang HO, Yun I, Bae SK, Bae MK. | 04/21/2012 |
| Rs10487667 polymorphism in the CYP5A1 gene might be a risk factor of myocardial infarction in the Uigur population in Xinjiang. | [Association of Rs10487667 genetic polymorphism of thromboxane synthase with myocardial infarction in Uigur population of Xinjiang].
Wang BZ, Ma YT, Fu ZY, Xie X, Zhang XL, Chen BD, Liu F, Yu ZX. | 12/17/2011 |
| Data suggest that targeting thromboxane synthase alone, or in combination with conventional chemotherapy is a potential therapeutic strategy for NSCLC. | Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer.
Cathcart MC, Gately K, Cummins R, Kay E, O'Byrne KJ, Pidgeon GP., Free PMC Article | 07/30/2011 |
| The rare allele of rs6962291 may play a protective role against aspirin hypersensitivity via a lower catalytic activity of the TBXAS1 gene, attributed to the increase of a nonfunctioning isoform of TBXAS1. | Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients.
Oh SH, Kim YH, Park SM, Cho SH, Park JS, Jang AS, Park SW, Uh ST, Lee YM, Kim MK, Choi IS, Cho SH, Hong CS, Lee YW, Lee JY, Choi BW, Park BL, Shin HD, Park CS. | 07/23/2011 |
| The TC genotype and T allele of thromboxane synthase are risk factors of myocardial infarction. | [Association of the Pro1770Leu polymorphism in CYP5A1 gene with myocardial infarction in Uigur population of Xinjiang].
Wang BZ, Ma YT, Fu ZY, Xie X, Chen BD, Zhang XL, Liu F, Yu ZX. | 02/26/2011 |