| In silico analysis of single nucleotide polymorphism (rs34377097) of TBXA2R gene and pollen induced bronchial asthma susceptibility in West Bengal population, India. | In silico analysis of single nucleotide polymorphism (rs34377097) of TBXA2R gene and pollen induced bronchial asthma susceptibility in West Bengal population, India.
Ganai I, Saha I, Banerjee P, Laha A, Sultana S, Sultana N, Biswas H, Moitra S, Podder S., Free PMC Article | 03/27/2023 |
| Thromboxane A2 receptor activation via Galpha13-RhoA/C-ROCK-LIMK2-dependent signal transduction inhibits angiogenic sprouting of human endothelial cells. | Thromboxane A(2) receptor activation via G(α13)-RhoA/C-ROCK-LIMK2-dependent signal transduction inhibits angiogenic sprouting of human endothelial cells.
Eckenstaler R, Ripperger A, Hauke M, Braun H, Ergün S, Schwedhelm E, Benndorf RA. | 06/25/2022 |
| Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis. | Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis.
Liang X, Zhou Y, Li S. | 10/30/2021 |
| The association between thromboxane A2 receptor gene polymorphisms and the risk of cerebral infarction. | The association between thromboxane A(2) receptor gene polymorphisms and the risk of cerebral infarction.
Mei L, Shen Z, Wu C. | 06/26/2021 |
| Signal transducer and activator of transcription 3 (STAT3) phosphorylation regulates thromboxane A2 receptor activity in human platelets. | Signal transducer and activator of transcription 3 (STAT3) phosphorylation regulates thromboxane A(2) receptor activity in human platelets.
Latorre AM, Santos MT, Vallés J, Bonanad S, Moscardó A. | 08/1/2020 |
| Down-regulation of forkhead box protein P1 (FOXP1) increases prostanoid TP receptor beta (TPbeta) expression in THP-1 monocytes. | Differential expression of the TPα and TPβ isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPβ during monocyte-macrophage differentiation.
Mulvaney EP, O'Sullivan ÁG, Eivers SB, Reid HM, Kinsella BT. | 02/29/2020 |
| the TBXA2R rs4523 G allele may contribute to protection against Kawasaki disease and decreased risk of coronary artery aneurysm complications in a southern Chinese population. | TBXA2R rs4523 G allele is associated with decreased susceptibility to Kawasaki disease.
Che D, Pi L, Xu Y, Fu L, Zhou H, Wang Z, Huang P, Zhang L, Gu X. | 01/18/2020 |
| high-risk gene-gene interactions among TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 were associated with higher platelet activation, and independently associated with higher risk of carotid stenosis in ischemic stroke patients. | The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke.
Yi X, Lin J, Zhou Q, Huang R, Chai Z., Free PMC Article | 04/6/2019 |
| Differential TBXA2 receptor transcript stability is dependent on the C924T polymorphism | Differential TBXA2 receptor transcript stability is dependent on the C924T polymorphism.
De Iuliis V, Ursi S, Pennelli A, Caruso M, Nunziata A, Marino A, Flati V, Cipollone F, Giamberardino MA, Vitullo G, Toniato E, Conti P, Martinotti S. | 12/22/2018 |
| The tumour suppressors FOXP1 and NKX3.1, strongly implicated in PCa development, were identified as key transcription factors regulating TPbeta expression through Prm3 in both PCa cell lines. | Regulated expression of the TPβ isoform of the human T prostanoid receptor by the tumour suppressors FOXP1 and NKX3.1: Implications for the role of thromboxane in prostate cancer.
O'Sullivan AG, Eivers SB, Mulvaney EP, Kinsella BT. | 12/22/2018 |
| The study of patients with naturally occurring variants within TBXA2R associated with bleeding and abnormal TPalpha receptor function has provided a powerful insight in defining the critical role of TPalpha in thrombus formation. | TBXA2R gene variants associated with bleeding.
Mundell SJ, Mumford A., Free PMC Article | 11/24/2018 |
| these data demonstrate that TPalpha/TPbeta can act as neoplastic and epigenetic regulators by mimicking and/or enhancing the actions of androgens within the prostate and provides further mechanistic insights into the role of the TXA2/TP signalling axis in prostate cancer, including potentially in CRPC. | Regulation of protein kinase C-related kinase (PRK) signalling by the TPα and TPβ isoforms of the human thromboxane A(2) receptor: Implications for thromboxane- and androgen- dependent neoplastic and epigenetic responses in prostate cancer.
O'Sullivan AG, Mulvaney EP, Kinsella BT. | 11/24/2018 |
| Data show that thromboxane A2 receptor beta-isoform (TPbeta) is highly expressed in intrauterine growth restriction (IUGR) placentae but is absent from healthy placentae. | Role for the thromboxane A2 receptor β-isoform in the pathogenesis of intrauterine growth restriction.
Powell KL, Stevens V, Upton DH, McCracken SA, Simpson AM, Cheng Y, Tasevski V, Morris JM, Ashton AW., Free PMC Article | 05/19/2018 |
| We conclude that hyperglycemia activates thromboxane A2 receptor to impair the integrity and function of blood-brain barrier via the ROCK-PTEN-Akt-eNOS pathway. | Hyperglycemia via activation of thromboxane A2 receptor impairs the integrity and function of blood-brain barrier in microvascular endothelial cells.
Zhao Z, Hu J, Gao X, Liang H, Yu H, Liu S, Liu Z., Free PMC Article | 03/10/2018 |
| data presented herein propose a novel diagnostic and prognostic potential for TPalpha and TPbeta in the histopathological assessment of PCa. While TPalpha and TPbeta are differentially expressed and independently regulated, increased levels of TPbeta, TPalpha or both correlated with increased risk of recurrence and reduced disease-free survival time. | Expression of the TPα and TPβ isoforms of the thromboxane prostanoid receptor (TP) in prostate cancer: clinical significance and diagnostic potential.
Mulvaney EP, Shilling C, Eivers SB, Perry AS, Bjartell A, Kay EW, Watson RW, Kinsella BT., Free PMC Article | 03/3/2018 |
| TBXA2R is a novel breast cancer-associated gene required for the survival and migratory behaviour of a subset of Triple Negative Breast Cancer (TNBC). | Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs).
Orr K, Buckley NE, Haddock P, James C, Parent JL, McQuaid S, Mullan PB., Free PMC Article | 02/10/2018 |
| TXA2R rs1131882TT genotype is associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients. | Genetic variants of PTGS2, TXA2R and TXAS1 are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients.
Yi X, Lin J, Luo H, Wang C, Liu Y., Free PMC Article | 10/7/2017 |
| We demonstrate that Trp334 in the TPbeta C-terminus is critical for the CCT7 interaction and plays an important role in TPbeta maturation and cell-surface expression. | Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex.
Génier S, Degrandmaison J, Moreau P, Labrecque P, Hébert TE, Parent JL., Free PMC Article | 09/9/2017 |
| TBXA2R +924C/T polymorphism is associated with asthma risk | Association between thromboxane A2 receptor polymorphisms and asthma risk: A meta-analysis.
Pan Y, Li S, Xie X, Li M. | 03/25/2017 |
| A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms. | Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy.
Peng LL, Zhao YQ, Zhou ZY, Jin J, Zhao M, Chen XM, Chen LY, Cai YF, Li JL, Huang M., Free PMC Article | 03/18/2017 |
| Data suggest that thromboxane A2/TBXA2R signaling promotes multiple myeloma cell proliferation by reducing delay at G2/M phase via up-regulation of MAP kinase pathway, up-regulation of cyclin B1/CDK1 expression, and down-regulation of apoptosis. | Thromboxane A2 Receptor Inhibition Suppresses Multiple Myeloma Cell Proliferation by Inducing p38/c-Jun N-terminal Kinase (JNK) Mitogen-activated Protein Kinase (MAPK)-mediated G2/M Progression Delay and Cell Apoptosis.
Liu Q, Tao B, Liu G, Chen G, Zhu Q, Yu Y, Yu Y, Xiong H., Free PMC Article | 08/6/2016 |
| The results of this study show that TXA2R polymorphisms may affect platelet function and the risk of developing cerebral ischemia. | Thromboxane A2 receptor polymorphism in association with cerebral infarction and its regulation on platelet function.
Shao J, Fu Y, Yang W, Yan J, Zhao J, Chen S, Xia W. | 01/2/2016 |
| Which could be attenuated by treatment with a TP antagonist (PTXA2). | Regulation of the tumor suppressor FOXO3 by the thromboxane-A2 receptors in urothelial cancer.
Sobolesky PM, Halushka PV, Garrett-Mayer E, Smith MT, Moussa O., Free PMC Article | 05/30/2015 |
| TXA2 receptor associated with lipid rafts in platelets is important for functional platelet responses to TXA2 | The association of thromboxane A2 receptor with lipid rafts is a determinant for platelet functional responses.
Moscardó A, Vallés J, Latorre A, Santos MT. | 10/18/2014 |
| Data suggest TBXA2R requires Ser324 for normal activity; Ser324A mutant is insensitive to activation by protein kinase A/cell hypoxia, has high affinity for agonists (thromboxane A2/analogs), and participates in agonist-induced calcium mobilization. | Thromboxane receptor hyper-responsiveness in hypoxic pulmonary hypertension requires serine 324.
Santhosh KT, Sikarwar AS, Hinton M, Chelikani P, Dakshinamurti S., Free PMC Article | 10/11/2014 |