| Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3beta pathway. | Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway.
Li J, Zuo L, Geng Z, Li Q, Cheng Y, Yang Z, Shi R, Zhou Y, Nie W, Wang Y, Zhang X, Ge S, Song X, Hu J., Free PMC Article | 10/15/2022 |
| A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer. | A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer.
Saxena M, Kalathur RKR, Rubinstein N, Vettiger A, Sugiyama N, Neutzner M, Coto-Llerena M, Kancherla V, Ercan C, Piscuoglio S, Fischer J, Fagiani E, Cantù C, Basler K, Christofori G. | 01/16/2021 |
| Our study revealed an association between Pygo2 function and obesity or diabetes. we showed that Pygo2 exhibited a declined expression pattern during adipocyte differentiation, resulting in an attenuated Wnt/beta-catenin output level. We further showed impaired glucose tolerance and decreased systemic insulin sensitivity in Pygo2-deficient mice. | Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin-Axin2-GSK3β Signaling Pathway.
Xie YY, Mo CL, Cai YH, Wang WJ, Hong XX, Zhang KK, Liu QF, Liu YJ, Hong JJ, He T, Zheng ZZ, Mo W, Li BA. | 02/9/2019 |
| Suggest that Pygo2 has a tumor promoting function related to Wnt/ss-catenin signaling activity during intestinal tumor initiation and progression. | The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression.
Talla SB, Brembeck FH., Free PMC Article | 02/24/2018 |
| Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation. | A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
Cantù C, Pagella P, Shajiei TD, Zimmerli D, Valenta T, Hausmann G, Basler K, Mitsiadis TA. | 11/18/2017 |
| It analyzed Wnt1-cre(+/-)::Pygo2(-/-) mice in which the beta-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells. | Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development.
Narytnyk A, Gillinder K, Verdon B, Clewes O, Sieber-Blum M., Free PMC Article | 01/17/2015 |
| These findings identify Pygo2 as an important regulator of Wnt/beta-catenin function in skin epithelia and p53 activation as a prominent downstream event of beta-catenin/Pygo2 action in stem cell activation. | Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia.
Sun P, Watanabe K, Fallahi M, Lee B, Afetian ME, Rheaume C, Wu D, Horsley V, Dai X., Free PMC Article | 09/20/2014 |
| these results suggest that Pygo2 acts at a step downstream of mammary stem cell accumulation to facilitate transformation, and that it regulates the tumor initiating capacity and lineage preference of the already transformed mammary cells, in MMTV-Wnt1 mice. | Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice.
Watanabe K, Fallahi M, Dai X., Free PMC Article | 04/5/2014 |
| even in the absence of the potentially redundant Pygo1, Pygo2 does not require the H3K4me2/3 binding activity to sustain its function during mouse development | The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.
Cantù C, Valenta T, Hausmann G, Vilain N, Aguet M, Basler K. | 07/20/2013 |
| Pygo2 converges with Wnt/beta-catenin signaling on progenitor cell regulation and cell cycle gene expression. | Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation.
Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, Li B, Dai X., Free PMC Article | 01/21/2010 |
| Pygo2 is involved in the chromatin remodeling events that lead to nuclear compaction of male germ cells | Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation.
Nair M, Nagamori I, Sun P, Mishra DP, Rhéaume C, Li B, Sassone-Corsi P, Dai X., Free PMC Article | 01/21/2010 |
| Study finds canonical Wnt signaling to be predominantly active in the mesenchyme at the time when mPygo2 is required and demonstrate the dependence of Wnt signal transduction on mPygo2. | Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation.
Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M., Free PMC Article | 01/21/2010 |
| Pygo2 can function in the Wnt pathway, but its activity in lens development is Wnt pathway-independent | pygopus 2 has a crucial, Wnt pathway-independent function in lens induction.
Song N, Schwab KR, Patterson LT, Yamaguchi T, Lin X, Potter SS, Lang RA. | 01/21/2010 |
| ablation of pygo2 expression causes defects in morphogenesis of both ectodermally and endodermally derived tissues, including brain, eyes, hair follicles, and lung | Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2.
Li B, Rhéaume C, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X. | 01/21/2010 |
| In mammals, the Pygo1/Pygo2 genes are not absolutely required for canonical Wnt signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt signal intensity | Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.
Schwab KR, Patterson LT, Hartman HA, Song N, Lang RA, Lin X, Potter SS., Free PMC Article | 01/21/2010 |
| Mouse pygo2 expression was detected in the developing epidermis and hair follicles, which suggests that mpygo2 might mediate the effect of this signaling pathway in mouse skin. | Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component.
Li B, Mackay DR, Ma J, Dai X., Free PMC Article | 01/21/2010 |