| The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function. | The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.
Guo F, Fernando T, Zhu X, Shi Y. | 03/8/2023 |
| Neurokinin receptors in drug and alcohol addiction. | Neurokinin receptors in drug and alcohol addiction.
Schank JR., Free PMC Article | 07/31/2021 |
| Identified a newly discovered stopgain mutation in tachykinin receptor 3 (TACR3) in nonobstructive azoospermia paitents. | A novel stopgain mutation c.G992A (p.W331X) in TACR3 gene was identified in nonobstructive azoospermia by targeted next-generation sequencing.
Geng D, Yang X, Wang R, Deng S, Li L, Hu X, Jiang Y, Liu R., Free PMC Article | 05/4/2019 |
| Three Single-nucleotide polymorphisms (on chromosomes 3 and 11) were associated with vasomotor menopause symptoms in the African American group. However, 14 Single-nucleotide polymorphisms, all located on chromosome 4 in the tachykinin receptor 3 (TACR3) locus, had similar effect sizes across studies/participants' ancestry. Genetic variation in TACR3 may contribute to the risk of vasomotor menopause symptoms. | Association of genetic variation in the tachykinin receptor 3 locus with hot flashes and night sweats in the Women's Health Initiative Study.
Crandall CJ, Manson JE, Hohensee C, Horvath S, Wactawski-Wende J, LeBlanc ES, Vitolins MZ, Nassir R, Sinsheimer JS., Free PMC Article | 02/17/2018 |
| observations of interspecies variation in the neurokinin 3 receptor brain localization with more extensive distribution in guinea pig than in primate brain; in the human brain, specific binding to the neurokinin 3 receptor was highest in the amygdala and in the hypothalamus and very low in other regions examined | Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628.
Varnäs K, Finnema SJ, Stepanov V, Takano A, Tóth M, Svedberg M, Møller Nielsen S, Khanzhin NA, Juhl K, Bang-Andersen B, Halldin C, Farde L., Free PMC Article | 02/3/2018 |
| High NK-3R expression is associated with Oral Squamous Cell Carcinoma. | Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma.
Obata K, Shimo T, Okui T, Matsumoto K, Takada H, Takabatake K, Kunisada Y, Ibaragi S, Yoshioka N, Kishimoto K, Nagatsuka H, Sasaki A. | 11/4/2017 |
| reduced to an almost undetectable level in polycystic ovary syndrome granulosa cells | Neurokinin B Exerts Direct Effects on the Ovary to Stimulate Estradiol Production.
Qi X, Salem M, Zhou W, Sato-Shimizu M, Ye G, Smitz J, Peng C. | 07/1/2017 |
| Neuropeptide derivatives to regulate the reproductive axis: Kisspeptin receptor (KISS1R) ligands and neurokinin-3 receptor (NK3R) ligands. | Neuropeptide derivatives to regulate the reproductive axis: Kisspeptin receptor (KISS1R) ligands and neurokinin-3 receptor (NK3R) ligands.
Oishi S, Fujii N. | 02/18/2017 |
| results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix | Tachykinin Receptor 3 Distribution in Human Oral Squamous Cell Carcinoma.
Obata K, Shimo T, Okui T, Matsumoto K, Takada H, Takabatake K, Kunisada Y, Ibaragi S, Nagatsuka H, Sasaki A. | 02/4/2017 |
| mutations in TAC and TACR3 are not a common cause for ICPP. | Mutational analysis of TAC and TACR3 in idiopathic central precocious puberty.
Krstevska-Konstantinova M, Tasic VB, Montenegro LR, Dervisov D, Beneduzzi D, Gontijo Silveira LF, Gucev ZS. | 03/26/2016 |
| None of the 4 single polymorphisms studied in TACR3 are linked directly to puberty onset time, but A63P in TAC3 is statistically associated with precocious puberty. | Association study of TAC3 and TACR3 gene polymorphisms with idiopathic precocious puberty in Chinese girls.
Xin X, Zhang J, Chang Y, Wu Y. | 09/26/2015 |
| Elevated CRP is likely a pathogenic factor contributing to preeclampsia by binding to phosphocholinated neurokinin B and preferentially activating NK3R. | Neurokinin 3 receptor and phosphocholine transferase: missing factors for pathogenesis of C-reactive protein in preeclampsia.
Parchim NF, Wang W, Iriyama T, Ashimi OA, Siddiqui AH, Blackwell S, Sibai B, Kellems RE, Xia Y., Free PMC Article | 03/7/2015 |
| data indicate that GPR54 and TACR3 gene mutations are not a frequent cause of ICPP. The identified A/G synonymous SNP (dbSNP ID: rs10407968) located in exon 1 of the gene is not likely to have a pathogenic role in exon splicing | Absence of GPR54 and TACR3 mutations in sporadic cases of idiopathic central precocious puberty.
Leka-Emiri S, Louizou E, Kambouris M, Chrousos G, De Roux N, Kanaka-Gantenbein C. | 12/20/2014 |
| Studies indicate the molecular mechanisms by which NK3R mutations cause GnRH deficiency. | TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients.
Noel SD, Abreu AP, Xu S, Muyide T, Gianetti E, Tusset C, Carroll J, Latronico AC, Seminara SB, Carroll RS, Kaiser UB., Free PMC Article | 06/7/2014 |
| Expression of the gene encoding TACR3 is significantly up-regulated in leiomyomas, compared with matched myometrium. | Differentially regulated expression of neurokinin B (NKB)/NK3 receptor system in uterine leiomyomata.
Cañete H, Dorta I, Hernández M, Cejudo Roman A, Candenas L, Pinto FM, Valladares F, Báez D, Montes de Oca F, Bello AR, Almeida TA. | 02/1/2014 |
| the rs2765 SNP predicted the degree of impairment of learning and memory in 209 elderly patients with cognitive impairments | Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism.
de Souza Silva MA, Lenz B, Rotter A, Biermann T, Peters O, Ramirez A, Jessen F, Maier W, Hüll M, Schröder J, Frölich L, Teipel S, Gruber O, Kornhuber J, Huston JP, Müller CP, Schäble S., Free PMC Article | 12/14/2013 |
| Rare variants in the TAC3 and TACR3 genes were identified in patients with central pubertal disorders and loss-of-function variants of TACR3 were associated with the normosmic IHH phenotype. | Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders.
Tusset C, Noel SD, Trarbach EB, Silveira LF, Jorge AA, Brito VN, Cukier P, Seminara SB, Mendonça BB, Kaiser UB, Latronico AC., Free PMC Article | 08/31/2013 |
| Sex differences in the neurokinin B system in the human infundibular nucleus. | Sex differences in the neurokinin B system in the human infundibular nucleus.
Taziaux M, Swaab DF, Bakker J. | 02/16/2013 |
| Data suggest that mutations in TACR3 and GNRHR are the most common causative mutations in normosmic idiopathic hypogonadotropic hypogonadism in families in Turkey. | Distribution of gene mutations associated with familial normosmic idiopathic hypogonadotropic hypogonadism.
Gürbüz F, Kotan LD, Mengen E, Şıklar Z, Berberoğlu M, Dökmetaş S, Kılıçlı MF, Güven A, Kirel B, Saka N, Poyrazoğlu Ş, Cesur Y, Doğan M, Özen S, Özbek MN, Demirbilek H, Kekil MB, Temiz F, Önenli Mungan N, Yüksel B, Topaloğlu AK., Free PMC Article | 02/16/2013 |
| NKB/NK(3)R and kisspeptin/KISS1R are present in female peripheral reproductive tissues with colocalization of both systems in some non-neuronal cell populations of the human female genital tract. | Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract.
Cejudo Roman A, Pinto FM, Dorta I, Almeida TA, Hernández M, Illanes M, Tena-Sempere M, Candenas L. | 06/30/2012 |
| The gonadotropin axis dysfunction associated with nCHH due to TAC3/TACR3 mutations is related to a low GnRH pulsatile frequency leading to a low frequency of alpha-subunit pulses and to an elevated FSH/LH ratio. | Normosmic congenital hypogonadotropic hypogonadism due to TAC3/TACR3 mutations: characterization of neuroendocrine phenotypes and novel mutations.
Francou B, Bouligand J, Voican A, Amazit L, Trabado S, Fagart J, Meduri G, Brailly-Tabard S, Chanson P, Lecomte P, Guiochon-Mantel A, Young J., Free PMC Article | 06/2/2012 |
| report of a Japanese female with hypogonadism(IHH) and compound heterozygous TACR3 mutations and her heterozygous parents; results suggest hypothalamic dysfunction as primary cause for IHH in patients with biallelic TACR3 mutations | Hypothalamic dysfunction in a female with isolated hypogonadotropic hypogonadism and compound heterozygous TACR3 mutations and clinical manifestation in her heterozygous mother.
Fukami M, Maruyama T, Dateki S, Sato N, Yoshimura Y, Ogata T. | 09/27/2010 |
| broad cohort of normosmic hypogonadotropic hypogonadism probands was screened for mutations in TAC3/TACR3 to evaluate the prevalence of such mutations and define the genotype/phenotype relationships | TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood.
Gianetti E, Tusset C, Noel SD, Au MG, Dwyer AA, Hughes VA, Abreu AP, Carroll J, Trarbach E, Silveira LF, Costa EM, de Mendonça BB, de Castro M, Lofrano A, Hall JE, Bolu E, Ozata M, Quinton R, Amory JK, Stewart SE, Arlt W, Cole TR, Crowley WF, Kaiser UB, Latronico AC, Seminara SB., Free PMC Article | 07/5/2010 |
| NK-3R plays a crucial role in hypothalamic gonadotropin releasing hormone release in humans. | TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans.
Young J, Bouligand J, Francou B, Raffin-Sanson ML, Gaillez S, Jeanpierre M, Grynberg M, Kamenicky P, Chanson P, Brailly-Tabard S, Guiochon-Mantel A. | 05/31/2010 |
| Homozygosity for the TACR3 His148Leu mutation leads to failure of sexual maturation in humans, whereas signaling by the mutant receptor in vitro in response to either NKB or senktide is severely impaired. | Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor.
Guran T, Tolhurst G, Bereket A, Rocha N, Porter K, Turan S, Gribble FM, Kotan LD, Akcay T, Atay Z, Canan H, Serin A, O'Rahilly S, Reimann F, Semple RK, Topaloglu AK., Free PMC Article | 01/21/2010 |