| The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function. | The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.
Guo F, Fernando T, Zhu X, Shi Y. | 03/8/2023 |
| Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome. | Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome.
Guzelkas I, Orbak Z, Doneray H, Ozturk N, Sagsoz N. | 07/16/2022 |
| The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty. | The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty.
Atay E, Kılınç S, Ulfer G, Yigitbasi T, Cakici C, Turan M, Ceran O, Atay Z. | 11/13/2021 |
| Endocytic recycling prevents copper accumulation in astrocytoma cells stimulated with copper-bound neurokinin B. | Endocytic recycling prevents copper accumulation in astrocytoma cells stimulated with copper-bound neurokinin B.
Menon R, Christofides K, Jones CE. | 09/12/2020 |
| The administration of an NK3R antagonist indicates a role for Neurokinin B in the regulation of luteinising hormone (LH)/gonadotropin-releasing hormone (GnRH) in postmenopausal women, whereas the lack of response to kisspeptin may reflect the hypo-oestrogenic state. These data support a link of LH/GnRH pulsatility and vasomotor symptoms with NK3R antagonism as a potential therapeutic approach. | Neurokinin 3 Receptor Antagonism Reveals Roles for Neurokinin B in the Regulation of Gonadotropin Secretion and Hot Flashes in Postmenopausal Women.
Skorupskaite K, George JT, Veldhuis JD, Millar RP, Anderson RA. | 01/12/2019 |
| Data suggest that basal serum neurokinin B level can be used as an adjunctive parameter to differentiate idiopathic central precocious puberty (ICPP) from premature thelarche (PT). | Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche.
Parlak M, Türkkahraman D, Ellidağ HY, Çelmeli G, Parlak AE, Yılmaz N., Free PMC Article | 03/24/2018 |
| acts through NK3 receptors in granulosa cells to stimulate steroid production | Neurokinin B Exerts Direct Effects on the Ovary to Stimulate Estradiol Production.
Qi X, Salem M, Zhou W, Sato-Shimizu M, Ye G, Smitz J, Peng C. | 07/1/2017 |
| mutations in TAC and TACR3 are not a common cause for ICPP. | Mutational analysis of TAC and TACR3 in idiopathic central precocious puberty.
Krstevska-Konstantinova M, Tasic VB, Montenegro LR, Dervisov D, Beneduzzi D, Gontijo Silveira LF, Gucev ZS. | 03/26/2016 |
| Plasma neurokinin B level is higher in patients with NDHT, indicating an unfavorable cardiovascular prognosis. | Serum neurokinin B levels in newly diagnosed nondipper hypertensive patients.
Akkoyun DC, Akyuz A, Alpsoy S, Aydin M, Erselcan K. | 01/30/2016 |
| Colocalization experiments provided evidence for the presence of cocaine- and amphetamine-regulated transcript (CART) in KP-immunoreactive (IR) and perikarya and in KP-IR and NKB-IR axon varicosities. | Colocalization of cocaine- and amphetamine-regulated transcript with kisspeptin and neurokinin B in the human infundibular region.
Skrapits K, Borsay BÁ, Herczeg L, Ciofi P, Bloom SR, Ghatei MA, Dhillo WS, Liposits Z, Hrabovszky E., Free PMC Article | 11/21/2015 |
| Amino acid substitution A63P in TAC3 gene was statistically associated with the puberty onset time in Chinese girls. | Association study of TAC3 and TACR3 gene polymorphisms with idiopathic precocious puberty in Chinese girls.
Xin X, Zhang J, Chang Y, Wu Y. | 09/26/2015 |
| SP may influence the KP and NKB secretory output via additional autocrine/paracrine mechanisms or regulate GnRH neurosecretion directly. | Substance P immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region.
Hrabovszky E, Borsay BÁ, Rácz K, Herczeg L, Ciofi P, Bloom SR, Ghatei MA, Dhillo WS, Liposits Z., Free PMC Article | 01/24/2015 |
| Copper can enter cultured astrocytoma cells and subsequently open plasma membrane calcium channels, but when bound to NKB, copper ion uptake is inhibited. | The tachykinin peptide neurokinin B binds copper forming an unusual [CuII(NKB)2] complex and inhibits copper uptake into 1321N1 astrocytoma cells.
Russino D, McDonald E, Hejazi L, Hanson GR, Jones CE., Free PMC Article | 05/31/2014 |
| Expression of the gene encoding NKB (TAC3) is up-regulated 20-fold in leiomyomas, compared with matched myometrium. | Differentially regulated expression of neurokinin B (NKB)/NK3 receptor system in uterine leiomyomata.
Cañete H, Dorta I, Hernández M, Cejudo Roman A, Candenas L, Pinto FM, Valladares F, Báez D, Montes de Oca F, Bello AR, Almeida TA. | 02/1/2014 |
| Rare variants in the TAC3 and TACR3 genes were identified in patients with central pubertal disorders and loss-of-function variants of TACR3 were associated with the normosmic IHH phenotype. | Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders.
Tusset C, Noel SD, Trarbach EB, Silveira LF, Jorge AA, Brito VN, Cukier P, Seminara SB, Mendonça BB, Kaiser UB, Latronico AC., Free PMC Article | 08/31/2013 |
| Interactions between kisspeptins and neurokinin B. | Interactions between kisspeptins and neurokinin B.
Navarro VM., Free PMC Article | 08/31/2013 |
| Report neurokinin B immunoreactivity in the human brainstem. | Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem.
Duque E, Mangas A, Salinas P, Díaz-Cabiale Z, Narváez JA, Coveñas R. | 06/15/2013 |
| Sex differences in the neurokinin B system in the human infundibular nucleus. | Sex differences in the neurokinin B system in the human infundibular nucleus.
Taziaux M, Swaab DF, Bakker J. | 02/16/2013 |
| these immunohistochemical data suggest an aging-related moderate enhancement in central NKB signaling. | Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man.
Molnár CS, Vida B, Sipos MT, Ciofi P, Borsay BÁ, Rácz K, Herczeg L, Bloom SR, Ghatei MA, Dhillo WS, Liposits Z, Hrabovszky E., Free PMC Article | 01/26/2013 |
| NKB neurons in the arcuate nucleus do not synthesize detectable amounts of kisspeptin and dynorphin in young male humans. These data call for a critical use of the KNDy neuron terminology when referring to the pulse generator of the hypothalamus | Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept.
Hrabovszky E, Sipos MT, Molnár CS, Ciofi P, Borsay BÁ, Gergely P, Herczeg L, Bloom SR, Ghatei MA, Dhillo WS, Liposits Z., Free PMC Article | 12/22/2012 |
| NKB/NK(3)R and kisspeptin/KISS1R are present in female peripheral reproductive tissues with colocalization of both systems in some non-neuronal cell populations of the human female genital tract. | Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract.
Cejudo Roman A, Pinto FM, Dorta I, Almeida TA, Hernández M, Illanes M, Tena-Sempere M, Candenas L. | 06/30/2012 |
| The gonadotropin axis dysfunction associated with nCHH due to TAC3/TACR3 mutations is related to a low GnRH pulsatile frequency leading to a low frequency of alpha-subunit pulses and to an elevated FSH/LH ratio. | Normosmic congenital hypogonadotropic hypogonadism due to TAC3/TACR3 mutations: characterization of neuroendocrine phenotypes and novel mutations.
Francou B, Bouligand J, Voican A, Amazit L, Trabado S, Fagart J, Meduri G, Brailly-Tabard S, Chanson P, Lecomte P, Guiochon-Mantel A, Young J., Free PMC Article | 06/2/2012 |
| The significantly increased maternal plasma levels of NKB and ET-1 of patients with preeclampsia occur at early pregnancy, before the onset of clinical symptoms. | [Relationship between neurokinin B and endothelin-1 and hypertensive disorders complicating pregnancy].
Li ZM, Zhao Y, Chen Q, Zou L, Wang ZH. | 10/22/2011 |
| Future studies will be needed to determine whether NKB signaling plays a permissive role in the onset of puberty--REVIEW | Neurokinin B and the hypothalamic regulation of reproduction.
Rance NE, Krajewski SJ, Smith MA, Cholanian M, Dacks PA., Free PMC Article | 03/26/2011 |
| kisspeptin and neurokinin B are coexpressed in the arcuate nucleus in the mammalian hypothalamus, suggesting that these systems are closely related and potential partners of the regulation of the reproductive axis--REVIEW | Impact of mutations in kisspeptin and neurokinin B signaling pathways on human reproduction.
Silveira LG, Tusset C, Latronico AC. | 03/26/2011 |