| On the genetic basis of tail-loss evolution in humans and apes. | On the genetic basis of tail-loss evolution in humans and apes.
Xia B, Zhang W, Zhao G, Zhang X, Bai J, Brosh R, Wudzinska A, Huang E, Ashe H, Ellis G, Pour M, Zhao Y, Coelho C, Zhu Y, Miller A, Dasen JS, Maurano MT, Kim SY, Boeke JD, Yanai I., Free PMC Article | 03/1/2024 |
| Association between TBXT rs2305089 polymorphism and chordoma in Iranian patients identified by a developed T-ARMS-PCR assay. | Association between TBXT rs2305089 polymorphism and chordoma in Iranian patients identified by a developed T-ARMS-PCR assay.
Jalessi M, Gholami MS, Razmara E, Hassanzadeh S, Sadeghipour A, Jahanbakhshi A, Tabibkhooei A, Bahrami E, Falah M., Free PMC Article | 03/19/2022 |
| Recurrent loss of chromosome 22 and SMARCB1 deletion in extra-axial chordoma: A clinicopathological and molecular analysis. | Recurrent loss of chromosome 22 and SMARCB1 deletion in extra-axial chordoma: A clinicopathological and molecular analysis.
Wen X, Cimera R, Aryeequaye R, Abhinta M, Athanasian E, Healey J, Fabbri N, Boland P, Zhang Y, Hameed M., Free PMC Article | 03/19/2022 |
| Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity. | Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity.
Sheppard HE, Dall'Agnese A, Park WD, Shamim MH, Dubrulle J, Johnson HL, Stossi F, Cogswell P, Sommer J, Levy J, Sharifnia T, Wawer MJ, Nabet B, Gray NS, Clemons PA, Schreiber SL, Workman P, Young RA, Lin CY., Free PMC Article | 02/26/2022 |
| Machine learning based tissue analysis reveals Brachyury has a diagnosis value in breast cancer. | Machine learning based tissue analysis reveals Brachyury has a diagnosis value in breast cancer.
Li K, Wang Q, Lu Y, Pan X, Liu L, Cheng S, Wu B, Song Z, Gao W., Free PMC Article | 12/25/2021 |
| Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide. | Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide.
Pinto F, Costa ÂM, Andrade RP, Reis RM., Free PMC Article | 10/30/2021 |
| Genetic variants of TBX6 and TBXT identified in patients with congenital scoliosis in Southern China. | Genetic variants of TBX6 and TBXT identified in patients with congenital scoliosis in Southern China.
Feng X, Cheung JPY, Je JSH, Cheung PWH, Chen S, Yue M, Wang N, Choi VNT, Yang X, Song YQ, Luk KDK, Gao B. | 09/4/2021 |
| Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death. | Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death.
Cottone L, Cribbs AP, Khandelwal G, Wells G, Ligammari L, Philpott M, Tumber A, Lombard P, Hookway ES, Szommer T, Johansson C, Brennan PE, Pillay N, Jenner RG, Oppermann U, Flanagan AM. | 02/13/2021 |
| Signifying their developmental function, the key mesoderm specifier BRACHYURY (T) is accompanied by yylncT, which localizes to the active T locus during mesoderm commitment. | yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs.
Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo JC, Derks JP, Akhade VS, Kargapolova Y, Georgomanolis T, Messling JE, Gramm M, Brant L, Rehimi R, Vargas NE, Kuroczik A, Yang TP, Sahito RGA, Franzen J, Hescheler J, Sachinidis A, Peifer M, Rada-Iglesias A, Kanduri M, Costa IG, Kanduri C, Papantonis A, Kurian L. | 03/28/2020 |
| hordomas can be primarily diagnosed by fine needle aspiration cytology in a typical clinicoradiological setting with a combination of key cytomorphological features...An exact diagnosis has treatment implications and requires confirmation by brachyury immunostaining. | Clinicocytopathological spectrum, including uncommon forms, of nine cases of chordomas with immunohistochemical results, including brachyury immunostaining: A single institutional experience.
Rekhi B, Karmarkar S. | 03/28/2020 |
| Activation of the PI3K/Akt pathway and Brachyury copy number gain are strongly associated with Brachyury overexpression, which appears to be a key event in chordoma growth regulation. These findings suggest that targeting Brachyury and PI3K/Akt signaling may be an effective new approach for treating chordoma. | Brachyury gene copy number gain and activation of the PI3K/Akt pathway: association with upregulation of oncogenic Brachyury expression in skull base chordoma.
Otani R, Mukasa A, Shin M, Omata M, Takayanagi S, Tanaka S, Ueki K, Saito N. | 09/14/2019 |
| these results indicate that Brachyury plays an oncogenic role in testicular germ cell tumors | Brachyury oncogene is a prognostic factor in high-risk testicular germ cell tumors.
Pinto F, Cárcano FM, da Silva ECA, Vidal DO, Scapulatempo-Neto C, Lopes LF, Reis RM. | 03/30/2019 |
| BRACHYURY and SOX2 synergistically promote cancer stemness in oral cancer cells. | Transfection of T-Box Transcription Factor BRACHYURY and SOX2 Synergistically Promote Self-Renewal and Invasive Phenotype in Oral Cancer Cells.
Akimoto N, Nakamura K, Hijioka H, Kume K, Matsumura Y, Sugiura T., Free PMC Article | 02/23/2019 |
| The lipodystrophic hotspot LMNA p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks in type 2 familial partial lipodystrophy. | The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks.
Briand N, Guénantin AC, Jeziorowska D, Shah A, Mantecon M, Capel E, Garcia M, Oldenburg A, Paulsen J, Hulot JS, Vigouroux C, Collas P. | 02/9/2019 |
| Brachyury expression in tumor samples is not a sensitive indicator of prognosis in chordomas | Chordoma: Immunohistochemical Analysis of Brachury.
Sun HI, Guduk M, Gucyetmez B, Yapicier O, Pamir MN. | 07/28/2018 |
| Notochordal transcription factor Brachyury gene duplication in sporadic chordoma | The driver landscape of sporadic chordoma.
Tarpey PS, Behjati S, Young MD, Martincorena I, Alexandrov LB, Farndon SJ, Guzzo C, Hardy C, Latimer C, Butler AP, Teague JW, Shlien A, Futreal PA, Shah S, Bashashati A, Jamshidi F, Nielsen TO, Huntsman D, Baumhoer D, Brandner S, Wunder J, Dickson B, Cogswell P, Sommer J, Phillips JJ, Amary MF, Tirabosco R, Pillay N, Yip S, Stratton MR, Flanagan AM, Campbell PJ., Free PMC Article | 03/3/2018 |
| FGFR1/MAPK may be important for brachyury activation in lung cancer, and this pathway may be an appealing therapeutic target for a subset of brachyury-driven lung cancer. | Regulation of brachyury by fibroblast growth factor receptor 1 in lung cancer.
Hu Y, Feng X, Mintz A, Petty WJ, Hsu W., Free PMC Article | 02/24/2018 |
| our results indicate that Brachyury contributes to tumor chemotherapy resistance, constituting an attractive target for advanced prostate cancer patients | Brachyury as a potential modulator of androgen receptor activity and a key player in therapy resistance in prostate cancer.
Pinto F, Pértega-Gomes N, Vizcaíno JR, Andrade RP, Cárcano FM, Reis RM., Free PMC Article | 01/13/2018 |
| A strong association was observed between nuclear brachyury protein expression and the stage of disease, with nuclear brachyury being more predominant in metastatic vs primary tumors. | Brachyury, a vaccine target, is overexpressed in triple-negative breast cancer.
Hamilton DH, Roselli M, Ferroni P, Costarelli L, Cavaliere F, Taffuri M, Palena C, Guadagni F., Free PMC Article | 12/30/2017 |
| rs2305089 variant in T (brachyury) gene is associated with response to therapy in Spinal column chordoma. | Spinal column chordoma: prognostic significance of clinical variables and T (brachyury) gene SNP rs2305089 for local recurrence and overall survival.
Bettegowda C, Yip S, Lo SL, Fisher CG, Boriani S, Rhines LD, Wang JY, Lazary A, Gambarotti M, Wang WL, Luzzati A, Dekutoski MB, Bilsky MH, Chou D, Fehlings MG, McCarthy EF, Quraishi NA, Reynolds JJ, Sciubba DM, Williams RP, Wolinsky JP, Zadnik PL, Zhang M, Germscheid NM, Kalampoki V, Varga PP, Gokaslan ZL, AOSpine Knowledge Forum Tumor., Free PMC Article | 09/16/2017 |
| Brachyury was significantly associated with estrogen receptor positive and human epidermal growth factor receptor 2 negative status; further study would be needed to clarify how it affects treatment prognosis. | Expression of epithelial-mesenchymal transition driver brachyury and status of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in predicting treatment responses to neoadjuvant chemotherapy of breast cancer.
Lee KH, Kim EY, Park YL, Do SI, Chae SW, Park CH. | 06/24/2017 |
| Brachyury is a candidate marker for predicting the clinical efficacy of tamoxifen. | Brachyury promotes tamoxifen resistance in breast cancer by targeting SIRT1.
Li K, Ying M, Feng D, Du J, Chen S, Dan B, Wang C, Wang Y. | 02/4/2017 |
| Overexpression of Brachyury in the cytoplasm is predictive of poor prognosis in gastrointestinal stromal tumors. | The embryonic Brachyury transcription factor is a novel biomarker of GIST aggressiveness and poor survival.
Pinto F, Campanella NC, Abrahão-Machado LF, Scapulatempo-Neto C, de Oliveira AT, Brito MJ, Andrade RP, Guimarães DP, Reis RM. | 12/24/2016 |
| Results showed that the high expression of SMC1 often promoted epithelial-mesenchymal transition, accompanied by the enhanced expression of Brachyury in triple-negative breast cancer cells. | SMC1 promotes epithelial-mesenchymal transition in triple-negative breast cancer through upregulating Brachyury.
Li K, Ying M, Feng D, Chen Y, Wang J, Wang Y. | 12/24/2016 |
| The distinct expression patterns of T gene isoforms may contribute to the pathogenesis of skull base chordomas. | T gene isoform expression pattern is significantly different between chordomas and notochords.
Wang K, Hu Q, Wang L, Chen W, Tian K, Cao C, Wu Z, Jia G, Zhang L, Zeng C, Zhang J. | 02/6/2016 |