| Activated CTHRC1 promotes glycolysis in endothelial cells: Implications for metabolism and angiogenesis. | Activated CTHRC1 promotes glycolysis in endothelial cells: Implications for metabolism and angiogenesis.
Toomey BH, Mitrovic SA, Lindner-Liaw M, Leon Vazquez RG, Kacer D, Ryzhov S, Prudovsky I, Lindner V., | 12/18/2023 |
| CTHRC1 promotes anaplastic thyroid cancer progression by upregulating the proliferation, migration, and invasion of tumor cells. | CTHRC1 promotes anaplastic thyroid cancer progression by upregulating the proliferation, migration, and invasion of tumor cells.
Chen Y, Jia L, Zhao K, Chen Z, Han Y, He X., Free PMC Article | 06/13/2023 |
| Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro. | Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro.
Feng Y, Hu J, Liu F, Shang Y. | 05/18/2023 |
| Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway. | Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway.
Wang D, Zhang Y, Ye T, Zhang R, Zhang L, Shi D, Li T, Xia G, Niu K, Zhao Z, Chen Y, Pan W, Liu L, Jin X, Shen C., Free PMC Article | 03/21/2023 |
| GPR180 is a component of TGFbeta signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1. | GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1.
Balazova L, Balaz M, Horvath C, Horváth Á, Moser C, Kovanicova Z, Ghosh A, Ghoshdastider U, Efthymiou V, Kiehlmann E, Sun W, Dong H, Ding L, Amri EZ, Nuutila P, Virtanen KA, Niemi T, Ukropcova B, Ukropec J, Pelczar P, Lamla T, Hamilton B, Neubauer H, Wolfrum C., Free PMC Article | 01/15/2022 |
| The role of CTHRC1 in hair follicle regenerative capacity restored by plantar dermis homogenate. | The role of CTHRC1 in hair follicle regenerative capacity restored by plantar dermis homogenate.
Zhang Y, Enhejirigala, Li Z, Song W, Yao B, Li J, Wang Y, Duan X, Yuan X, Huang S, Fu X. | 11/22/2021 |
| Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction. | Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction.
Ruiz-Villalba A, Romero JP, Hernández SC, Vilas-Zornoza A, Fortelny N, Castro-Labrador L, San Martin-Uriz P, Lorenzo-Vivas E, García-Olloqui P, Palacio M, Gavira JJ, Bastarrika G, Janssens S, Wu M, Iglesias E, Abizanda G, de Morentin XM, Lasaga M, Planell N, Bock C, Alignani D, Medal G, Prudovsky I, Jin YR, Ryzhov S, Yin H, Pelacho B, Gomez-Cabrero D, Lindner V, Lara-Astiaso D, Prósper F., Free PMC Article | 10/2/2021 |
| Biochemical and structural cues of 3D-printed matrix synergistically direct MSC differentiation for functional sweat gland regeneration. | Biochemical and structural cues of 3D-printed matrix synergistically direct MSC differentiation for functional sweat gland regeneration.
Yao B, Wang R, Wang Y, Zhang Y, Hu T, Song W, Li Z, Huang S, Fu X., Free PMC Article | 11/21/2020 |
| the binding of osteoclast-derived CTHRC1 to WAIF1 in stromal cells activates PKCdelta-ERK osteoblastogenic signaling. | WAIF1 Is a Cell-Surface CTHRC1 Binding Protein Coupling Bone Resorption and Formation.
Matsuoka K, Kohara Y, Naoe Y, Watanabe A, Ito M, Ikeda K, Takeshita S. | 10/26/2019 |
| CTHRC1 secreted from osteocytes and osteoblasts functions as an inhibitor of osteoclast differentiation via inhibition of NFkappaB-dependent signaling. | Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1.
Jin YR, Stohn JP, Wang Q, Nagano K, Baron R, Bouxsein ML, Rosen CJ, Adarichev VA, Lindner V., Free PMC Article | 12/23/2017 |
| These data suggest Cthrc1 reduces fibrotic tissue formation in bleomycin-induced lung fibrosis and the effect is potent enough to limit the decline in lung function. | Cthrc1 lowers pulmonary collagen associated with bleomycin-induced fibrosis and protects lung function.
Binks AP, Beyer M, Miller R, LeClair RJ., Free PMC Article | 12/9/2017 |
| CTHRC1 was established as a novel marker of activated synoviocytes in murine experimental arthritis and rheumatoid arthritis | Collagen triple helix repeat containing 1 is a new promigratory marker of arthritic pannus.
Shekhani MT, Forde TS, Adilbayeva A, Ramez M, Myngbay A, Bexeitov Y, Lindner V, Adarichev VA., Free PMC Article | 11/11/2017 |
| CTHRC1 is an osteoclast-secreted coupling factor that regulates bone remodeling. | Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation.
Takeshita S, Fumoto T, Matsuoka K, Park KA, Aburatani H, Kato S, Ito M, Ikeda K., Free PMC Article | 11/30/2013 |
| This study demonstrated that Cthrc1 plays a negative regulatory role, fine-tuning the onset of peripheral myelination. | Cthrc1 is a negative regulator of myelination in Schwann cells.
Apra C, Richard L, Coulpier F, Blugeon C, Gilardi-Hebenstreit P, Vallat JM, Lindner V, Charnay P, Decker L., Free PMC Article | 11/2/2013 |
| this is the first demonstration of Cthrc1 as a marker of the severity of the disease progression in the dystrophic muscles. | The involvement of collagen triple helix repeat containing 1 in muscular dystrophies.
Spector I, Zilberstein Y, Lavy A, Genin O, Barzilai-Tutsch H, Bodanovsky A, Halevy O, Pines M. | 08/10/2013 |
| Hormonal functions of Cthrc1 include regulation of lipid storage and cellular glycogen levels with potentially broad implications for cell metabolism and physiology. | Cthrc1, a novel circulating hormone regulating metabolism.
Stohn JP, Perreault NG, Wang Q, Liaw L, Lindner V., Free PMC Article | 06/1/2013 |
| Data show a dramatic discrepancy between ROSA26 reporter activity and Pdgfrb promoter driven Cre dependent myc-tagged Cthrc1 transgene expression. | Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries.
Cuttler AS, LeClair RJ, Stohn JP, Wang Q, Sorenson CM, Liaw L, Lindner V., Free PMC Article | 01/28/2012 |
| Downregulated by dietary beta-carotene in lungs of knockout Bcmo1-deficient mice. | Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice.
van Helden YG, Godschalk RW, Heil SG, Bunschoten A, Hessel S, Amengual J, Bonet ML, von Lintig J, van Schooten FJ, Keijer J. | 09/20/2010 |
| Cthrc1 increases bone mass as a positive regulator of osteoblastic bone formation | Cthrc1 is a positive regulator of osteoblastic bone formation.
Kimura H, Kwan KM, Zhang Z, Deng JM, Darnay BG, Behringer RR, Nakamura T, de Crombrugghe B, Akiyama H., Free PMC Article | 01/21/2010 |
| Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. | Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, Sasaki H. | 01/21/2010 |
| Cthrc1 expression overlaps considerably with those reported for TGF-beta family members and interstitial collagens. | Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1).
Durmus T, LeClair RJ, Park KS, Terzic A, Yoon JK, Lindner V. | 01/21/2010 |