| Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1. | Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1.
Stephan G, Haddock S, Wang S, Erdjument-Bromage H, Liu W, Ravn-Boess N, Frenster JD, Bready D, Cai J, Ronnen R, Sabio-Ortiz J, Fenyo D, Neubert TA, Placantonakis DG., Free PMC Article | 09/25/2024 |
| miRNA-363-3p Hinders Proliferation, Migration, Invasion and Autophagy of Thyroid Cancer Cells by Controlling SYT1 Transcription to affect NF-kappaB. | miRNA-363-3p Hinders Proliferation, Migration, Invasion and Autophagy of Thyroid Cancer Cells by Controlling SYT1 Transcription to affect NF-κB.
Zhang J, Ren G, Huang T, Sang Y, Zhong Y, Yi Y. | 02/7/2024 |
| Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B(+) vesicle pathway in liver cancer. | Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B(+) vesicle pathway in liver cancer.
Yamada K, Motohashi S, Oikawa T, Tago N, Koizumi R, Ono M, Tachibana T, Yoshida A, Yoshida S, Shimoda M, Oka M, Yoneda Y, Yoshida K., Free PMC Article | 09/17/2022 |
| Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder. | Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder.
Melland H, Bumbak F, Kolesnik-Taylor A, Ng-Cordell E, John A, Constantinou P, Joss S, Larsen M, Fagerberg C, Laulund LW, Thies J, Emslie F, Willemsen M, Kleefstra T, Pfundt R, Barrick R, Chang R, Loong L, Alfadhel M, van der Smagt J, Nizon M, Kurian MA, Scott DJ, Ziarek JJ, Gordon SL, Baker K., Free PMC Article | 04/30/2022 |
| The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores. | The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores.
Wu Z, Dharan N, McDargh ZA, Thiyagarajan S, O'Shaughnessy B, Karatekin E., Free PMC Article | 10/30/2021 |
| The role of synaptic biomarkers in the spectrum of neurodegenerative diseases. | The role of synaptic biomarkers in the spectrum of neurodegenerative diseases.
Mazzucchi S, Palermo G, Campese N, Galgani A, Della Vecchia A, Vergallo A, Siciliano G, Ceravolo R, Hampel H, Baldacci F. | 08/21/2021 |
| The Synaptotagmin-1 C2B Domain Is a Key Regulator in the Stabilization of the Fusion Pore. | The Synaptotagmin-1 C2B Domain Is a Key Regulator in the Stabilization of the Fusion Pore.
Caparotta M, Tomes CN, Mayorga LS, Masone D. | 07/3/2021 |
| 12q21 deletion syndrome: Narrowing the critical region down to 1.6 Mb including SYT1 and PPP1R12A. | 12q21 deletion syndrome: Narrowing the critical region down to 1.6 Mb including SYT1 and PPP1R12A.
Niclass T, Le Guyader G, Beneteau C, Joubert M, Pizzuti A, Giuffrida MG, Bernardini L, Gilbert-Dussardier B, Bilan F, Egloff M. | 06/12/2021 |
| Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder.
Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER., Free PMC Article | 10/10/2020 |
| Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder. | Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder.
Viola TW, Schuch JB, Rovaris DL, Genovese R, Tondo L, Sanvicente-Vieira B, Zaparte A, Cupertino RB, da Silva BS, Bau CHD, Grassi-Oliveira R., Free PMC Article | 08/22/2020 |
| SGIP1alpha is an endocytic adaptor dedicated to the retrieval of surface-stranded Syt1. | SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses.
Lee SE, Jeong S, Lee U, Chang S., Free PMC Article | 05/30/2020 |
| Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7 | Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7.
Tran HT, Anderson LH, Knight JD., Free PMC Article | 04/11/2020 |
| SYT1-rs2251214 was significantly associated with susceptibility to Cocaine Use Disorder, where the G allele presented increased risk for the disorder in the genetic models tested. This is the same allele that was associated with increased risk for ADHD and other externalizing behaviors. | The association between SYT1-rs2251214 and cocaine use disorder further supports its role in psychiatry.
da Silva BS, Cupertino RB, Schuch JB, Kappel DB, Sanvicente-Vieira B, Bandeira CE, von Diemen L, Kessler FHP, Grevet EH, Grassi-Oliveira R, Bau CHD, Rovaris DL. | 04/4/2020 |
| The fatty acylated region of synaptotagmin-1 is likely to adopt beta-structure in biological membranes. This preference for beta-structure versus alpha-helix has functional implications for the role of synaptotagmin-1 in synaptic vesicle exocytosis. | Insights into the structure and molecular topography of the fatty acylated domain of synaptotagmin-1.
Ruchala P, Waring AJ, Cilluffo M, Whitelegge JP, Gundersen CB. | 11/9/2019 |
| Studies indicate that synaptotagmin 1 (Syt1) has two main groups of binding partners: anionic phospholipids and the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) complex after vesicle docking [Review]. | Models of synaptotagmin-1 to trigger Ca(2+) -dependent vesicle fusion.
Park Y, Ryu JK. | 06/15/2019 |
| SYT1-rs2251214 was associated with categorical short-term response to immediate-release methylphenida (IR-MPH) and with percentage of inattention and oppositional defiant disorder symptoms reduction. It was also associated with short-term treatment persistence and with months of treatment the long-term protocol, suggesting that SYT1-rs2251214 presents a broad influence in IR-MPH response variability in adults with ADHD | Exocytosis-related genes and response to methylphenidate treatment in adults with ADHD.
da Silva BS, Cupertino RB, Rovaris DL, Schuch JB, Kappel DB, Müller D, Bandeira CE, Victor MM, Karam RG, Mota NR, Rohde LA, Contini V, Grevet EH, Bau CHD. | 03/23/2019 |
| This result demonstrates that the choice of detergent used to reconstitute Syt1 can modulate the state of the neuronal Ca(2+) -sensor. | Choice of reconstitution protocol modulates the aggregation state of full-length membrane-reconstituted synaptotagmin-1.
Nyenhuis SB, Cafiso DS., Free PMC Article | 03/9/2019 |
| The present study replicates previously suggested association of the SYT1-rs2251214 SNP with ADHD in adults. | Replicated association of Synaptotagmin (SYT1) with ADHD and its broader influence in externalizing behaviors.
Cupertino RB, Schuch JB, Bandeira CE, da Silva BS, Rovaris DL, Kappel DB, Contini V, Salatino-Oliveira A, Vitola ES, Karam RG, Hutz MH, Rohde LA, Grevet EH, Bau CHD, Mota NR. | 07/21/2018 |
| The MD simulations revealed that all peptides induced significant Syt1 rigidity by binding in the cleft of the C2A-C2B interface. The consequence of this binding event is the suppression of the protein motion associated with conformational change of Syt1 from the closed form to the open form. | Molecular modeling elucidates the cellular mechanism of synaptotagmin-SNARE inhibition: a novel plausible route to anti-wrinkle activity of botox-like cosmetic active molecules.
Wongrattanakamon P, Nimmanpipug P, Sirithunyalug B, Jiranusornkul S. | 07/14/2018 |
| Although both otoferlin and synaptotagmin bind membrane fusion SNARE proteins, only otoferlin interacts with the L-type calcium channel Cav1.3. | Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels.
Hams N, Padmanarayana M, Qiu W, Johnson CP., Free PMC Article | 06/9/2018 |
| Circular oligomerization is an intrinsic property of SYT1. | Circular oligomerization is an intrinsic property of synaptotagmin.
Wang J, Li F, Bello OD, Sindelar CV, Pincet F, Krishnakumar SS, Rothman JE., Free PMC Article | 05/19/2018 |
| that reduction in the synaptotagmin 1 level and presenilin 1-synaptotagmin 1 interactions in AD brain may present molecular underpinning of the pathogenic presenilin 1 conformation | Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production.
Zoltowska KM, Maesako M, Lushnikova I, Takeda S, Keller LJ, Skibo G, Hyman BT, Berezovska O., Free PMC Article | 02/24/2018 |
| findings show extended Synaptotagmi1 (E-Syt1), along with related E-Syt3, negatively modulates viral release into the extracellular milieu, cell-to-cell viral spread and viral entry, processes that implicate membrane fusion events; , these E-Syt proteins impacted formation of virus-induced syncytia; findings hint at the modulation of the viral fusion machinery by the E-Syt family of proteins | Extended Synaptotagmin 1 Interacts with Herpes Simplex Virus 1 Glycoprotein M and Negatively Modulates Virus-Induced Membrane Fusion.
El Kasmi I, Khadivjam B, Lackman M, Duron J, Bonneil E, Thibault P, Lippé R., Free PMC Article | 12/23/2017 |
| Using electron microscopy combined with targeted mutations, the authors show that under physiologically relevant conditions, both the Syt1 ring assembly and its rapid disruption by Ca(2+) involve the well-established functional surfaces on the C2B domain that are important for synaptic transmission. | Ring-like oligomers of Synaptotagmins and related C2 domain proteins.
Zanetti MN, Bello OD, Wang J, Coleman J, Cai Y, Sindelar CV, Rothman JE, Krishnakumar SS., Free PMC Article | 11/18/2017 |
| This study found that the CSF levels of synaptotagmin-1 were consistently elevated in patients with dementia due to Alzheimer's disease. | The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's disease.
Öhrfelt A, Brinkmalm A, Dumurgier J, Brinkmalm G, Hansson O, Zetterberg H, Bouaziz-Amar E, Hugon J, Paquet C, Blennow K., Free PMC Article | 10/14/2017 |