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    VAMP7 vesicle associated membrane protein 7 [ Homo sapiens (human) ]

    Gene ID: 6845, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Upregulation of vesicle-associated membrane protein 7 in breast cancer tissues.

    Upregulation of vesicle-associated membrane protein 7 in breast cancer tissues.
    Huang Y, Wu M, Li JD, Qin Z, Huang KQ, Cui JZ, Ou HL.

    07/15/2024
    The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.

    The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.
    Jian F, Wang S, Tian R, Wang Y, Li C, Li Y, Wang S, Fang C, Ma C, Rong Y.,

    02/6/2024
    VAMP7j: A Splice Variant of Human VAMP7 That Modulates Neurite Outgrowth by Regulating L1CAM Transport to the Plasma Membrane.

    VAMP7j: A Splice Variant of Human VAMP7 That Modulates Neurite Outgrowth by Regulating L1CAM Transport to the Plasma Membrane.
    Gasparotto M, Dall'Ara E, Vacca M, Filippini F., Free PMC Article

    01/12/2024
    The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis.

    The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis.
    Li D, Xu M, Wang Z, Huang P, Huang C, Chen Z, Tang G, Zhu X, Cai M, Qin S., Free PMC Article

    04/16/2022
    Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth.

    Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth.
    Wojnacki J, Nola S, Bun P, Cholley B, Filippini F, Pressé MT, Lipecka J, Man Lam S, N'guyen J, Simon A, Ouslimani A, Shui G, Fader CM, Colombo MI, Guerrera IC, Galli T.

    12/25/2021
    LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation.

    LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation.
    Peng X, Li X, Yang S, Huang M, Wei S, Ma Y, Li Y, Wu B, Jin H, Li B, Tang S, Fan Q, Liu J, Yang L, Li H., Free PMC Article

    12/11/2021
    A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers.

    A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers.
    Bowman SL, Le L, Zhu Y, Harper DC, Sitaram A, Theos AC, Sviderskaya EV, Bennett DC, Raposo-Benedetti G, Owen DJ, Dennis MK, Marks MS., Free PMC Article

    10/9/2021
    Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway.

    Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway.
    Davis LJ, Bright NA, Edgar JR, Parkinson MDJ, Wartosch L, Mantell J, Peden AA, Luzio JP., Free PMC Article

    09/4/2021
    A case series of infants with increased VAMP7 gene dosage at birth and virilization defects.

    A case series of infants with increased VAMP7 gene dosage at birth and virilization defects.
    Chávez-López S, de Jesús Lugo-Trampe J, Ibarra-Ramírez M, Calvo-Anguiano G, Martínez-de-Villarreal LE, Campos-Acevedo LD.

    08/7/2021
    DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.

    DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
    Tian X, Zheng P, Zhou C, Wang X, Ma H, Ma W, Zhou X, Teng J, Chen J., Free PMC Article

    06/12/2021
    Gene Copy Number Quantification of SHOX, VAMP7, and SRY for the Detection of Sex Chromosome Aneuploidies in Neonates.

    Gene Copy Number Quantification of SHOX, VAMP7, and SRY for the Detection of Sex Chromosome Aneuploidies in Neonates.
    Ibarra-Ramírez M, Lugo-Trampe JJ, Campos-Acevedo LD, Zamudio-Osuna M, Torres-Muñoz I, Gómez-Puente V, García-Castañeda G, Arredondo-Vázquez P, Rodríguez-Sánchez IP, Schaeffer SE, Velasco-Sepúlveda BH, Villarreal-Pérez JZ, Martínez-de-Villarreal LE.

    03/6/2021
    Cytotoxic Granule Exocytosis From Human Cytotoxic T Lymphocytes Is Mediated by VAMP7.

    Cytotoxic Granule Exocytosis From Human Cytotoxic T Lymphocytes Is Mediated by VAMP7.
    Chitirala P, Ravichandran K, Galgano D, Sleiman M, Krause E, Bryceson YT, Rettig J., Free PMC Article

    10/24/2020
    The pseudoautosomal region of human X and Y chromosome encoded VAMP7 protein was predicted to interact with at least 22 proteins encoded on the somatic chromosomes.

    Bioinformatics Annotation of Human Y Chromosome-Encoded Protein Pathways and Interactions.
    Rengaraj D, Kwon WS, Pang MG.

    04/6/2020
    GLUT5 required an interaction cascade of Rab11, Myo5B, Slp4a, Munc18-2, and Vamp7 with Stx3.

    Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.
    Vogel GF, Klee KM, Janecke AR, Müller T, Hess MW, Huber LA., Free PMC Article

    02/13/2016
    VAMP-7 participates in both platelet granule secretion and spreading and suggest a mechanism whereby VAMP-7 links granule exocytosis with actin reorganization.

    VAMP-7 links granule exocytosis to actin reorganization during platelet activation.
    Koseoglu S, Peters CG, Fitch-Tewfik JL, Aisiku O, Danglot L, Galli T, Flaumenhaft R., Free PMC Article

    10/24/2015
    highlight the role that VAMP3 and VAMP7 play in selection of the pathways leading to generation of ultrastructurally different LC3 compartments

    Role of VAMP3 and VAMP7 in the commitment of Yersinia pseudotuberculosis to LC3-associated pathways involving single- or double-membrane vacuoles.
    Ligeon LA, Moreau K, Barois N, Bongiovanni A, Lacorre DA, Werkmeister E, Proux-Gillardeaux V, Galli T, Lafont F., Free PMC Article

    07/25/2015
    Increased level of SNAP23-Syntaxin4-VAMP7 interaction correlates with decreased Syntaxin4 phosphorylation and trafficking of MT1-MMP to invadopodia during cellular invasion.

    SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion.
    Williams KC, McNeilly RE, Coppolino MG., Free PMC Article

    02/28/2015
    increased gene dosage of VAMP7, and thus higher expression levels of its protein product, enhances estrogen receptor action in male genitourinary tissues

    Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.
    Tannour-Louet M, Han S, Louet JF, Zhang B, Romero K, Addai J, Sahin A, Cheung SW, Lamb DJ., Free PMC Article

    09/20/2014
    CALM is able to sort VAMP4 and VAMP7, even though they have sorting signals for other clathrin adaptors.

    Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.
    Sahlender DA, Kozik P, Miller SE, Peden AA, Robinson MS., Free PMC Article

    02/22/2014
    Overexpression of Vamp7 inhibited the heterotypic fusion with lysosomes and the homotypic fusion between individual Coxiella phagosomes and replicative vacuoles.

    Endocytic SNAREs are involved in optimal Coxiella burnetii vacuole development.
    Campoy EM, Mansilla ME, Colombo MI.

    11/2/2013
    Activation of TI-VAMP-mediated exocytosis thus relies on tyrosine phosphorylation.

    Increased activity of the vesicular soluble N-ethylmaleimide-sensitive factor attachment protein receptor TI-VAMP/VAMP7 by tyrosine phosphorylation in the Longin domain.
    Burgo A, Casano AM, Kuster A, Arold ST, Wang G, Nola S, Verraes A, Dingli F, Loew D, Galli T., Free PMC Article

    06/29/2013
    hVps41 and VAMP7 are specifically involved in the fusion of trans-Golgi network-derived lysosome-associated membrane protein carriers with late endosomes.

    hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins.
    Pols MS, van Meel E, Oorschot V, ten Brink C, Fukuda M, Swetha MG, Mayor S, Klumperman J.

    06/22/2013
    In a mammalian tumor cell line a subset of VAMP7 (V-SNARE)-positive vacuoles colocalize with LC3 at the cell periphery (focal adhesions) upon starvation.

    ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner.
    Fader CM, Aguilera MO, Colombo MI., Free PMC Article

    05/11/2013
    Downregulation of VAMP7 expression inhibited the fusion of ATP-storing vesicles and ATP-mediated calcium wave propagation.

    TI-VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes.
    Verderio C, Cagnoli C, Bergami M, Francolini M, Schenk U, Colombo A, Riganti L, Frassoni C, Zuccaro E, Danglot L, Wilhelm C, Galli T, Canossa M, Matteoli M.

    02/23/2013
    VAMP7-SNARE motif is trapped between Varp and the VAMP7 longin domain, and hence Varp kinetically inhibits the ability of VAMP7 to form SNARE complexes

    The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation.
    Schäfer IB, Hesketh GG, Bright NA, Gray SR, Pryor PR, Evans PR, Luzio JP, Owen DJ., Free PMC Article

    02/9/2013
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