| Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer's disease continuum. | Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer's disease continuum.
Goossens J, Cervantes González A, Dewit N, Lidón L, Fortea J, Alcolea D, Lleó A, Belbin O, Vanmechelen E., Free PMC Article | 11/1/2023 |
| Non-coding variants in VAMP2 and SNAP25 affect gene expression: potential implications in migraine susceptibility. | Non-coding variants in VAMP2 and SNAP25 affect gene expression: potential implications in migraine susceptibility.
Felício D, Dias A, Martins S, Carvalho E, Lopes AM, Pinto N, Lemos C, Santos M, Alves-Ferreira M., Free PMC Article | 07/7/2023 |
| alpha-Synuclein Disrupts Vesicle Fusion by Two Mutant-Specific Mechanisms. | α-Synuclein Disrupts Vesicle Fusion by Two Mutant-Specific Mechanisms.
Yoo G, An HJ, Yeou S, Lee NK., Free PMC Article | 12/10/2022 |
| Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma. | Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma.
Wei XC, Xia YR, Zhou P, Xue X, Ding S, Liu LJ, Zhu F., Free PMC Article | 01/29/2022 |
| Oligomeric alpha-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease. | Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease.
Agliardi C, Meloni M, Guerini FR, Zanzottera M, Bolognesi E, Baglio F, Clerici M. | 12/11/2021 |
| The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores. | The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores.
Wu Z, Dharan N, McDargh ZA, Thiyagarajan S, O'Shaughnessy B, Karatekin E., Free PMC Article | 10/30/2021 |
| Amyloid-beta Peptides Disrupt Interactions Between VAMP-2 and SNAP-25 in Neuronal Cells as Determined by FRET/FLIM. | Amyloid-β Peptides Disrupt Interactions Between VAMP-2 and SNAP-25 in Neuronal Cells as Determined by FRET/FLIM.
Sharda N, Pengo T, Wang Z, Kandimalla KK. | 09/11/2021 |
| VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome. | VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome.
Lleó A, Carmona-Iragui M, Videla L, Fernández S, Benejam B, Pegueroles J, Barroeta I, Altuna M, Valldeneu S, Xiao MF, Xu D, Núñez-Llaves R, Querol-Vilaseca M, Sirisi S, Bejanin A, Iulita MF, Clarimón J, Blesa R, Worley P, Alcolea D, Fortea J, Belbin O., Free PMC Article | 08/21/2021 |
| Dlg4 and Vamp2 are involved in comorbid epilepsy and attention-deficit hyperactivity disorder: A microarray data study. | Dlg4 and Vamp2 are involved in comorbid epilepsy and attention-deficit hyperactivity disorder: A microarray data study.
Xi XJ, Tang JH, Zhang BB, Xiao X, Hu XY, Wan Y, Zhou C, Lin H. | 03/20/2021 |
| Ceramide induces a multicomponent intracellular calcium increase triggering the acrosome secretion in human sperm. | Ceramide induces a multicomponent intracellular calcium increase triggering the acrosome secretion in human sperm.
Vaquer CC, Suhaiman L, Pavarotti MA, De Blas GA, Belmonte SA. | 10/24/2020 |
| the present results indicated that circFAM53B could be a competing endogenous RNA (ceRNA) to competitively sponge miR646 and miR647 to upregulate VAMP2 and MDM2 expression at the posttranscriptional level, thus mediating the cellular behaviors of Ovarian cancer cells | Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways.
Sun D, Liu J, Zhou L. | 04/4/2020 |
| alpha-syn-VAMP2 interactions are necessary for alpha-syn-induced synaptic attenuation. | Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling.
Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S., Free PMC Article | 03/28/2020 |
| analysis of five heterozygous de novo mutations in VAMP2 in unrelated individuals presenting with a neurodevelopmental disorder characterized by axial hypotonia (which had been present since birth), intellectual disability, and autistic features | Mutations in the Neuronal Vesicular SNARE VAMP2 Affect Synaptic Membrane Fusion and Impair Human Neurodevelopment.
Salpietro V, Malintan NT, Llano-Rivas I, Spaeth CG, Efthymiou S, Striano P, Vandrovcova J, Cutrupi MC, Chimenz R, David E, Di Rosa G, Marce-Grau A, Raspall-Chaure M, Martin-Hernandez E, Zara F, Minetti C, Deciphering Developmental Disorders Study, SYNAPS Study Group, Bello OD, De Zorzi R, Fortuna S, Dauber A, Alkhawaja M, Sultan T, Mankad K, Vitobello A, Thomas Q, Mau-Them FT, Faivre L, Martinez-Azorin F, Prada CE, Macaya A, Kullmann DM, Rothman JE, Krishnakumar SS, Houlden H., Free PMC Article | 02/8/2020 |
| To investigate the possible roles of selected synaptic and presynaptic membrane protein genetic polymorphisms (VAMP2, SNAP-25, synaptotagmin, and syntaxin 1A) in patients with multiple sclerosis | Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis.
Yalın OÖ, Gökdoğan Edgünlü T, Karakaş Çelik S, Emre U, Güneş T, Erdal Y, Eroğlu Ünal A., Free PMC Article | 01/4/2020 |
| these findings implicate VAMP2 as the main VAMP isoform functionally involved in antibody secretion. | VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins.
Gómez-Jaramillo L, Romero-García R, Jiménez-Gómez G, Riegle L, Ramos-Amaya AB, Brieva JA, Kelly-Worden M, Campos-Caro A., Free PMC Article | 09/14/2019 |
| miR-185 inhibited osteosarcoma (OS) cell proliferation, migration and invasion. VAMP2 was validated as a direct target of miR-185. Study in human OS tissues confirm that decreased expression of miR-185 might be regarded as a tumor marker for the early diagnosis of OS, by manipulating of its interactive factors with VAMP2, to provide an effective novel therapeutic target for treatment of the OS tumor. | MicroRNA-185 inhibits proliferation, migration and invasion in human osteosarcoma MG63 cells by targeting vesicle-associated membrane protein 2.
Li L, Wang X, Liu D. | 04/13/2019 |
| these results indicate that the activation of beta-ARs induces secretory granules and cell membrane fusion via the interaction of VAMP-2 and syntaxin-4 in a PKA- and F-actin-dependent manner in human submandibular gland. Up-regulated beta-ARs might participate in altering protein secretion in transplanted submandibular gland by promoting the interaction of VAMP-2 with syntaxin-4. | β-adrenoceptor activation increased VAMP-2 and syntaxin-4 in secretory granules are involved in protein secretion of submandibular gland through the PKA/F-actin pathway.
Ding C, Cong X, Zhang Y, Li SL, Wu LL, Yu GY., Free PMC Article | 08/18/2018 |
| miR-493-5p overexpression promotes cell apoptosis and inhibits the proliferation and migration of liver cancer cells by negatively regulating the expression of VAMP. | MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2.
Wang G, Fang X, Han M, Wang X, Huang Q. | 08/4/2018 |
| Data suggest that A-syn (alpha-synuclein) promotes SNARE-dependent vesicle docking; phosphatidylserine (PS) removal from t-SNARE-bearing vesicles causes A-syn to inhibit vesicle docking; PS removal from v-SNARE-bearing vesicles promotes vesicle docking; the C-terminal 45 residues of A-syn are required for promotion of vesicle docking. (Here, t-SNARE is SNAP-25; v-SNARE is VAMP2.) | α-Synuclein may cross-bridge v-SNARE and acidic phospholipids to facilitate SNARE-dependent vesicle docking.
Lou X, Kim J, Hawk BJ, Shin YK., Free PMC Article | 07/15/2017 |
| A significant interactive two-locus model of STX1A_rs4363087|VAMP2_rs2278637 (presynaptic genes) was observed among SVC variants in all epilepsy cases. | Synergistic association of STX1A and VAMP2 with cryptogenic epilepsy in North Indian population.
Baghel R, Grover S, Kaur H, Jajodia A, Parween S, Sinha J, Srivastava A, Srivastava AK, Bala K, Chandna P, Kushwaha S, Agarwal R, Kukreti R., Free PMC Article | 06/10/2017 |
| VAMP2 is a promising new plasma cell marker | An Immunohistochemical Survey of SNARE Proteins Shows Distinct Patterns of Expression in Hematolymphoid Neoplasia.
Bhat R, Bhattacharyya PK, Ratech H. | 02/25/2017 |
| VAMP2 is involved in Porphyromonas gingivalis recycling pathway.VAMP2 is localized in early endosomes in gingival epithelial cells. | Intracellular periodontal pathogen exploits recycling pathway to exit from infected cells.
Takeuchi H, Takada A, Kuboniwa M, Amano A. | 02/18/2017 |
| The present study addressed for the first time the unique substrate recognition mechanism of LC/F5 substrate cleavage of VAMP-2 by Botulinum Neurotoxin subtype F5. | Mechanism of substrate recognition by the novel Botulinum Neurotoxin subtype F5.
Guo J, Chan EW, Chen S., Free PMC Article | 01/14/2017 |
| This study showed that decreased Levels of VAMP2 correlate with Duration of Dementia. | Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia.
Vallortigara J, Whitfield D, Quelch W, Alghamdi A, Howlett D, Hortobágyi T, Johnson M, Attems J, O'Brien JT, Thomas A, Ballard CG, Aarsland D, Francis PT. | 10/8/2016 |
| VAMP2-NRG1 is a novel oncogenic fusion gene representing a new addition to the list of NRG1 fusion genes, which together may form an important diagnostic and clinical category of lung adenocarcinoma cases | VAMP2-NRG1 Fusion Gene is a Novel Oncogenic Driver of Non-Small-Cell Lung Adenocarcinoma.
Jung Y, Yong S, Kim P, Lee HY, Jung Y, Keum J, Lee S, Kim J, Kim J. | 05/7/2016 |