| Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma. | Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma.
Chen Y, Weng X, Zhang C, Wang S, Wu X, Cheng B., Free PMC Article | 07/31/2024 |
| Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis. | Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis.
Kong M, Zhou J, Kang A, Kuai Y, Xu H, Li M, Miao X, Guo Y, Fan Z, Xu Y, Li Z. | 04/11/2024 |
| The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma. | The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
Kalita B, Sahu S, Bharadwaj A, Panneerselvam L, Martinez-Cebrian G, Agarwal M, Mathew SJ. | 02/15/2024 |
| SUV39H1 is a novel biomarker targeting oxidative phosphorylation in hepatitis B virus-associated hepatocellular carcinoma. | SUV39H1 is a novel biomarker targeting oxidative phosphorylation in hepatitis B virus-associated hepatocellular carcinoma.
Zhang Y, Lao W, Yang K, Kong X, Li Y, Yu X, Wang X, Liu Y, Li Z, Deng Y, Nie S, Bi C, Wu C, Zhai A., Free PMC Article | 12/1/2023 |
| SUV39H1 is a prognosis and immune microenvironment-related biomarker in diffuse large B-cell lymphoma. | SUV39H1 is a prognosis and immune microenvironment-related biomarker in diffuse large B-cell lymphoma.
Zhang Y, Qian S, Wen Q, Lei Y, Ge J, Kong X, Wang W, Wang Z, Hou H, Tang C, Wu S, Wang G, Li W, Zhang M, Zhang X, Chen Q. | 06/28/2023 |
| Decreased SUV39H1 at the promoter region leads to increased CREMalpha and accelerates autoimmune response in CD4[+] T cells from patients with systemic lupus erythematosus. | Decreased SUV39H1 at the promoter region leads to increased CREMα and accelerates autoimmune response in CD4(+) T cells from patients with systemic lupus erythematosus.
Luo S, Zhang H, Xie Y, Huang J, Luo D, Zhang Q., Free PMC Article | 12/31/2022 |
| Differences in SUV39H1 and androgen receptor distribution in adenomyomatous hyperplasia and prostatic adenocarcinoma. | Differences in SUV39H1 and androgen receptor distribution in adenomyomatous hyperplasia and prostatic adenocarcinoma.
Celik MA, Erdem H, Cankaya S, Arici YK. | 10/8/2022 |
| CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas. | CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas.
Niborski LL, Gueguen P, Ye M, Thiolat A, Ramos RN, Caudana P, Denizeau J, Colombeau L, Rodriguez R, Goudot C, Luccarini JM, Soudé A, Bournique B, Broqua P, Pace L, Baulande S, Sedlik C, Quivy JP, Almouzni G, Cohen JL, Zueva E, Waterfall JJ, Amigorena S, Piaggio E., Free PMC Article | 07/9/2022 |
| Histone Mark Profiling in Pediatric Astrocytomas Reveals Prognostic Significance of H3K9 Trimethylation and Histone Methyltransferase SUV39H1. | Histone Mark Profiling in Pediatric Astrocytomas Reveals Prognostic Significance of H3K9 Trimethylation and Histone Methyltransferase SUV39H1.
Klonou A, Korkolopoulou P, Gargalionis AN, Kanakoglou DS, Katifelis H, Gazouli M, Chlamydas S, Mitsios A, Kalamatianos T, Stranjalis G, Themistocleous MS, Papavassiliou KA, Sgouros S, Papavassiliou AG, Piperi C., Free PMC Article | 03/5/2022 |
| Suppressor of variegation 3-9 homologue 1 impairment and neutrophil-skewed systemic inflammation are associated with comorbidities in COPD. | Suppressor of variegation 3-9 homologue 1 impairment and neutrophil-skewed systemic inflammation are associated with comorbidities in COPD.
Chen TT, Wu SM, Chen KY, Tseng CH, Ho SC, Chuang HC, Feng PH, Liu WT, Han CL, Huang EW, Yeh YK, Lee KY., Free PMC Article | 01/8/2022 |
| EBP1 regulates Suv39H1 stability via the ubiquitin-proteasome system in neural development. | EBP1 regulates Suv39H1 stability via the ubiquitin-proteasome system in neural development.
Kim BS, Ko HR, Hwang I, Cho SW, Ahn JY., Free PMC Article | 01/8/2022 |
| Downregulation of SUV39H1 and CITED2 Exerts Additive Effect on Promoting Adipogenic Commitment of Human Mesenchymal Stem Cells. | Downregulation of SUV39H1 and CITED2 Exerts Additive Effect on Promoting Adipogenic Commitment of Human Mesenchymal Stem Cells.
Tan L, Tran L, Ferreyra S, Moran JA, Skovgaard Z, Trujillo A, Ibili E, Zhao Y., Free PMC Article | 12/18/2021 |
| MiR-520a-3p inhibits malignant progression of epithelial ovarian cancer by targeting SUV39H1 expression. | MiR-520a-3p inhibits malignant progression of epithelial ovarian cancer by targeting SUV39H1 expression.
Li J, Shao W, Zhao J. | 08/7/2021 |
| Effect of SUV39H1 Histone Methyltransferase Knockout on Expression of Differentiation-Associated Genes in HaCaT Keratinocytes. | Effect of SUV39H1 Histone Methyltransferase Knockout on Expression of Differentiation-Associated Genes in HaCaT Keratinocytes.
Sobiak B, Leśniak W., Free PMC Article | 07/10/2021 |
| Signal Activation of Hepatitis B Virus-Related Hepatocarcinogenesis by Up-regulation of SUV39h1. | Signal Activation of Hepatitis B Virus-Related Hepatocarcinogenesis by Up-regulation of SUV39h1.
Takeuchi Y, Tsuge M, Tsushima K, Suehiro Y, Fujino H, Ono A, Yamauchi M, Makokha GN, Nakahara T, Murakami E, Abe-Chayama H, Kawaoka T, Miki D, Imamura M, Aikata H, Hayes CN, Tateno C, Chayama K. | 04/3/2021 |
| SUV39H1 regulates the progression of MLL-AF9-induced acute myeloid leukemia. | SUV39H1 regulates the progression of MLL-AF9-induced acute myeloid leukemia.
Chu Y, Chen Y, Guo H, Li M, Wang B, Shi D, Cheng X, Guan J, Wang X, Xue C, Cheng T, Shi J, Yuan W., Free PMC Article | 02/27/2021 |
| SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth. | SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth.
Lu C, Klement JD, Yang D, Albers T, Lebedyeva IO, Waller JL, Liu K., Free PMC Article | 12/19/2020 |
| Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy. | Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy.
Qi L, Chi X, Zhang X, Feng X, Chu W, Zhang S, Wu J, Song Y, Zhang Y, Kong W, Yu Y, Zhang H., Free PMC Article | 09/5/2020 |
| Study suggests that increased chondrocyte proliferation occurs in the facet joint cartilage of Idiopathic scoliosis (IS) patients and may be promoted by the elevated levels of H3K9me3 and SUV39H1, which regulate the miR-15a/Bcl2 pathway. This dysregulation of chondrocyte proliferation could result in abnormal spinal growth and may additionally participate in the development and progression of IS. | Suv39h1 promotes facet joint chondrocyte proliferation by targeting miR-15a/Bcl2 in idiopathic scoliosis patients.
Li J, Yang G, Liu S, Wang L, Liang Z, Zhang H., Free PMC Article | 06/27/2020 |
| a SUV39H1-low chromatin state associates with, and promotes, migratory cell populations in cervical cancers | A SUV39H1-low chromatin state characterises and promotes migratory properties of cervical cancer cells.
Rodrigues C, Pattabiraman C, Vijaykumar A, Arora R, Narayana SM, Kumar RV, Notani D, Varga-Weisz P, Krishna S. | 05/30/2020 |
| No statistically significant difference in cytotoxic T-Lymphocytes (CTL) tumor infiltration is observed between microsatellite instable (MSI) and microsatellite stable colon carcinoma specimens. The expression of the H3K9me3-specific histone methyltransferase SUV39H1 is significantly elevated in human colon carcinoma compared with normal colon tissues. | SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion.
Lu C, Yang D, Klement JD, Oh IK, Savage NM, Waller JL, Colby AH, Grinstaff MW, Oberlies NH, Pearce CJ, Xie Z, Kulp SK, Coss CC, Phelps MA, Albers T, Lebedyeva IO, Liu K., Free PMC Article | 05/23/2020 |
| Results suggest that protein kinase CK2 (CK2) downregulation induces dephosphorylation of Ser 392 on tumor protein p53 (p53), which subsequently increases the stability of suppressor of variegation 3-9 homolog 1 protein (SUV39h1). | Dephosphorylation of p53 Ser 392 Enhances Trimethylation of Histone H3 Lys 9 via SUV39h1 Stabilization in CK2 Downregulation-Mediated Senescence.
Park JW, Bae YS., Free PMC Article | 04/25/2020 |
| The authors show that IFI16 is in complex with the H3K9 methyltransferase SUV39H1 and GLP and recruits them to the human herpesvirus 8 genome during de novo infection and latency. The resulting depositions of H3K9me2/me3 serve as a docking site for the heterochromatin-inducing HP1alpha protein leading into the IFI16-dependent epigenetic modifications and silencing of the virus lytic genes. | IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP.
Roy A, Ghosh A, Kumar B, Chandran B., Free PMC Article | 04/11/2020 |
| These results suggest that nuclear ErbB4 enhances H3K9me3 levels through tyrosine phosphorylation of SUV39H1 in NRG-1/ErbB4 signal-mediated chromatin remodeling. | Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling.
Nakajo H, Ishibashi K, Aoyama K, Kubota S, Hasegawa H, Yamaguchi N, Yamaguchi N. | 01/18/2020 |
| data reveal a novel role for CIITA in endothelial cells and present SUV39H1 as a druggable target in the intervention of endothelial dysfunction. | Class II transactivator (CIITA) mediates IFN-γ induced eNOS repression by enlisting SUV39H1.
Weng X, Zhang Y, Li Z, Yu L, Xu F, Fang M, Hou L, Ge J, Xu Y. | 08/10/2019 |