| Surf4, cargo trafficking, lipid metabolism, and therapeutic implications. | Surf4, cargo trafficking, lipid metabolism, and therapeutic implications.
Shen Y, Gu HM, Qin S, Zhang DW., Free PMC Article | 03/7/2023 |
| Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4. | Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4.
Tang X, Wang T, Guo Y., Free PMC Article | 01/7/2023 |
| High SURF4 expression is associated with poor prognosis of breast cancer. | High SURF4 expression is associated with poor prognosis of breast cancer.
Zhai J, Han J, Li C, Guo F, Ma F, Xu B., Free PMC Article | 12/17/2022 |
| Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export. | Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export.
Gomez-Navarro N, Maldutyte J, Poljak K, Peak-Chew SY, Orme J, Bisnett BJ, Lamb CH, Boyce M, Gianni D, Miller EA., Free PMC Article | 08/6/2022 |
| A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog. | A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog.
Tang X, Chen R, Mesias VSD, Wang T, Wang Y, Poljak K, Fan X, Miao H, Hu J, Zhang L, Huang J, Yao S, Miller EA, Guo Y., Free PMC Article | 05/14/2022 |
| SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport. | SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport.
Yan R, Chen K, Wang B, Xu K., Free PMC Article | 03/12/2022 |
| Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo. | Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo.
Devireddy S, Ferguson SM., Free PMC Article | 02/19/2022 |
| Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans. | Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans.
Wang X, Wang H, Xu B, Huang D, Nie C, Pu L, Zajac GJM, Yan H, Zhao J, Shi F, Emmer BT, Lu J, Wang R, Dong X, Dai J, Zhou W, Wang C, Gao G, Wang Y, Willer C, Lu X, Zhu Y, Chen XW. | 12/4/2021 |
| SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells. | SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells.
Yue Y, Xia L, Xu S, Wang C, Wang X, Lu W, Xie X., Free PMC Article | 09/18/2021 |
| The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion. | The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion.
Lin Z, King R, Tang V, Myers G, Balbin-Cuesta G, Friedman A, McGee B, Desch K, Ozel AB, Siemieniak D, Reddy P, Emmer B, Khoriaty R., Free PMC Article | 12/5/2020 |
| These results indicate that the cellular protein Surf4 is involved in the replication of positive-strand RNA viruses that use DMVs as RNA replication sites, providing new insights into DMV formation during virus replication and potential targets for the diagnosis and treatment of positive-strand RNA viruses. | Surfeit 4 Contributes to the Replication of Hepatitis C Virus Using Double-Membrane Vesicles.
Kong L, Aoyagi H, Yang Z, Ouyang T, Matsuda M, Fujimoto A, Watashi K, Suzuki R, Arita M, Yamagoe S, Dohmae N, Suzuki T, Suzuki T, Muramatsu M, Wakita T, Aizaki H., Free PMC Article | 06/13/2020 |
| Study findings revealed that knockdown of Surf4 increased expression and secretion of PCSK9, indicating a negligible role of Surf4 in PCSK9 secretion in cultured human hepatocytes. | Surf4 regulates expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) but is not required for PCSK9 secretion in cultured human hepatocytes.
Shen Y, Wang B, Deng S, Zhai L, Gu HM, Alabi A, Xia X, Zhao Y, Chang X, Qin S, Zhang DW. | 05/16/2020 |
| SFT-4 and Surf4 regulate the export of soluble proteins, including lipoproteins, from the endoplasmic reticulum (ER) and participate in ER exit site organization in animals. | SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization.
Saegusa K, Sato M, Morooka N, Hara T, Sato K., Free PMC Article | 05/18/2019 |
| Surf4 (or its yeast ortholog, Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum. | Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum.
Yin Y, Garcia MR, Novak AJ, Saunders AM, Ank RS, Nam AS, Fisher LW., Free PMC Article | 05/11/2019 |
| These findings support a model in which SURF4 functions as an endoplasmic reticulum cargo receptor mediating the efficient cellular secretion of PCSK9. | The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9.
Emmer BT, Hesketh GG, Kotnik E, Tang VT, Lascuna PJ, Xiang J, Gingras AC, Chen XW, Ginsburg D., Free PMC Article | 01/12/2019 |
| SURF4 demonstrated aberrant amplification and increased expression in the tumor tissues of several human cancer patients. | SURF4 has oncogenic potential in NIH3T3 cells.
Kim J, Hong CM, Park SM, Shin DH, Kim JY, Kwon SM, Kim JH, Kim CD, Lim DS, Lee D. | 11/10/2018 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Silencing Surf4 together with ERGIC-53 or silencing the p24 family member p25 induced an identical phenotype characterized by a reduced number of ERGIC clusters and fragmentation of the Golgi apparatus without effect on anterograde transport. | The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi.
Mitrovic S, Ben-Tekaya H, Koegler E, Gruenberg J, Hauri HP., Free PMC Article | 01/21/2010 |