| Dimeric assembly of human Suv3 helicase promotes its RNA unwinding function in mitochondrial RNA degradosome for RNA decay. | Dimeric assembly of human Suv3 helicase promotes its RNA unwinding function in mitochondrial RNA degradosome for RNA decay.
Jain M, Golzarroshan B, Lin CL, Agrawal S, Tang WH, Wu CJ, Yuan HS., Free PMC Article | 07/30/2022 |
| Mitochondrial RNA processing defect caused by a SUPV3L1 mutation in two siblings with a novel neurodegenerative syndrome. | Mitochondrial RNA processing defect caused by a SUPV3L1 mutation in two siblings with a novel neurodegenerative syndrome.
van Esveld SL, Rodenburg RJ, Al-Murshedi F, Al-Ajmi E, Al-Zuhaibi S, Huynen MA, Spelbrink JN., Free PMC Article | 05/14/2022 |
| Identification of immune cells and mRNA associated with prognosis of gastric cancer. | Identification of immune cells and mRNA associated with prognosis of gastric cancer.
Wang M, Li Z, Peng Y, Fang J, Fang T, Wu J, Zhou J., Free PMC Article | 11/21/2020 |
| the nucleolar- associated human SUV3 protein is an important factor in regulation of the cell cycle. | Human SUV3 helicase regulates growth rate of the HeLa cells and can localize in the nucleoli.
Szewczyk M, Fedoryszak-Kuśka N, Tkaczuk K, Dobrucki J, Waligórska A, Stępień PP. | 04/22/2017 |
| the capacity of hSuv3 DNA unwinding activity might be sensitive to the local availability of specific inorganic cofactors | Regulation of the human Suv3 helicase on DNA by inorganic cofactors.
Venø ST, Witt MB, Kulikowicz T, Bohr VA, Stevnsner T., Free PMC Article | 08/22/2015 |
| SUV3 bridges PNPase and mtPAP to form a transient complex in modulating mt-mRNA poly(A) tail length depending on the mitochondrial matrix Pi level. | Helicase SUV3, polynucleotide phosphorylase, and mitochondrial polyadenylation polymerase form a transient complex to modulate mitochondrial mRNA polyadenylated tail lengths in response to energetic changes.
Wang DD, Guo XE, Modrek AS, Chen CF, Chen PL, Lee WH., Free PMC Article | 10/25/2014 |
| Interaction between PNPase and hSuv3 is essential for efficient mitochondrial RNA degradation. | Human mitochondrial RNA decay mediated by PNPase-hSuv3 complex takes place in distinct foci.
Borowski LS, Dziembowski A, Hejnowicz MS, Stepien PP, Szczesny RJ., Free PMC Article | 04/6/2013 |
| The hSuv3p activity was found to be necessary in the regulation of stability of mature, properly formed mRNAs and for removal of the noncoding processing intermediates transcribed from both H and L-strands. | Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance.
Szczesny RJ, Borowski LS, Brzezniak LK, Dmochowska A, Gewartowski K, Bartnik E, Stepien PP., Free PMC Article | 02/15/2010 |
| The complex of hSUV3-hPNPase is an integral entity for efficient degradation of structured RNA and may be the long sought RNA-degrading complex in the mammalian mitochondria. | Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality.
Wang DD, Shu Z, Lieser SA, Chen PL, Lee WH., Free PMC Article | 01/21/2010 |
| SUV3 is essential for maintaining proper mitochondrial function, likely through a conserved role in mitochondrial RNA regulation. | Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells.
Khidr L, Wu G, Davila A, Procaccio V, Wallace D, Lee WH., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
Morgan AR, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, Jones L, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 03/13/2008 |
| Human SUV3 protein interacts with human WRN and BLM helicases. Silencing of the SUV3 gene in the human cell line HeLa resulted in elevation of homologous recombination as measured by the frequency of sister chromatid exchange during mitotic cell division. | Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.
Pereira M, Mason P, Szczesny RJ, Maddukuri L, Dziwura S, Jedrzejczak R, Paul E, Wojcik A, Dybczynska L, Tudek B, Bartnik E, Klysik J, Bohr VA, Stepien PP. | 01/21/2010 |
| Suv3 protein interacts with HBXIP, previously identified as a cofactor of survivin in suppression of apoptosis | Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP.
Minczuk M, Mroczek S, Pawlak SD, Stepien PP. | 01/21/2010 |
| Down-regulation of hSUV3 results in cell cycle perturbations and in apoptosis, which is both AIF- and caspase-dependent, and proceeds with the induction of p53. | Down-regulation of human RNA/DNA helicase SUV3 induces apoptosis by a caspase- and AIF-dependent pathway.
Szczesny RJ, Obriot H, Paczkowska A, Jedrzejczak R, Dmochowska A, Bartnik E, Formstecher P, Polakowska R, Stepien PP. | 01/21/2010 |
| Human SUV3 is an ATP-dependent multiple-substrate helicase; in addition to dsRNA and dsDNA unwinding activity, SUV3-70 and SUV3-83 can unwind heteroduplexes of RNA and DNA. | Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change.
Shu Z, Vijayakumar S, Chen CF, Chen PL, Lee WH. | 01/21/2010 |
| Localisation of hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA. | Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA.
Minczuk M, Piwowarski J, Papworth MA, Awiszus K, Schalinski S, Dziembowski A, Dmochowska A, Bartnik E, Tokatlidis K, Stepien PP, Borowski P., Free PMC Article | 01/21/2010 |
| data suggest that hSUV3 is a housekeeping gene with an enhancer region & regulatory elements in basal promoter | The 5' region of the human hSUV3 gene encoding mitochondrial DNA and RNA helicase: promoter characterization and alternative pre-mRNA splicing.
Minczuk M, Lilpop J, Boros J, Stepien PP. | 01/21/2010 |