| Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability. | Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability.
Miller CLW, Warner JL, Winston F., | 10/26/2023 |
| Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6. | Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6.
Wang J, Yang C, Cao H, Yang J, Meng W, Yu M, Yu L, Wang B., Free PMC Article | 03/7/2023 |
| SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression. | SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression.
Diao C, Guo P, Yang W, Sun Y, Liao Y, Yan Y, Zhao A, Cai X, Hao J, Hu S, Yu W, Chen M, Wang R, Li W, Zuo Y, Pan J, Hua C, Lu X, Fan W, Zheng Z, Deng W, Luo G, Guo W., Free PMC Article | 01/15/2022 |
| Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo. | Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo.
Žumer K, Maier KC, Farnung L, Jaeger MG, Rus P, Winter G, Cramer P. | 08/28/2021 |
| Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination. | Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination.
Narain A, Bhandare P, Adhikari B, Backes S, Eilers M, Dölken L, Schlosser A, Erhard F, Baluapuri A, Wolf E., Free PMC Article | 08/28/2021 |
| SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation. | SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation.
Li J, Xu X, Tiwari M, Chen Y, Fuller M, Bansal V, Tamayo P, Das S, Ghosh P, Sen GL., Free PMC Article | 02/20/2021 |
| SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells. | SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells.
Obara EAA, Aguilar-Morante D, Rasmussen RD, Frias A, Vitting-Serup K, Lim YC, Elbæk KJ, Pedersen H, Vardouli L, Jensen KE, Skjoth-Rasmussen J, Brennum J, Tuckova L, Strauss R, Dinant C, Bartek J, Hamerlik P., Free PMC Article | 10/10/2020 |
| Spt6 is a maintenance factor for centromeric CENP-A. | Spt6 is a maintenance factor for centromeric CENP-A.
Bobkov GOM, Huang A, van den Berg SJW, Mitra S, Anselm E, Lazou V, Schunter S, Feederle R, Imhof A, Lusser A, Jansen LET, Heun P., Free PMC Article | 08/29/2020 |
| SPT6 acts as a master regulator of Pol II elongation, favoring productive protein coding over non-productive and potentially deleterious lncRNA transcription. | Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence.
Nojima T, Tellier M, Foxwell J, Ribeiro de Almeida C, Tan-Wong SM, Dhir S, Dujardin G, Dhir A, Murphy S, Proudfoot NJ., Free PMC Article | 06/1/2019 |
| cryo-EM structure of an activated elongation complex of Sus scrofa Pol II and Homo sapiens DSIF, PAF and SPT6 was determined at 3.1 A resolution and compared to the structure of the paused elongation complex formed by Pol II, DSIF and NELF | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.
Vos SM, Farnung L, Boehning M, Wigge C, Linden A, Urlaub H, Cramer P. | 03/9/2019 |
| Altogether, these results indicate that a complex containing LEDGF/p75, Iws1, and Spt6 participates in regulating postintegration steps of HIV latency. | The integrase cofactor LEDGF/p75 associates with Iws1 and Spt6 for postintegration silencing of HIV-1 gene expression in latently infected cells.
Gérard A, Ségéral E, Naughtin M, Abdouni A, Charmeteau B, Cheynier R, Rain JC, Emiliani S. | 10/10/2015 |
| identified fibronectin, a component of the extracellular matrix and a mesenchymal marker, as a transcriptional target of Pak1 signaling | SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.
Bedi U, Scheel AH, Hennion M, Begus-Nahrmann Y, Rüschoff J, Johnsen SA. | 04/11/2015 |
| Spt6 is a unique histone chaperone capable of regulating the histone epigenetic state of both AID targets and the AID locus. | The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.
Begum NA, Stanlie A, Nakata M, Akiyama H, Honjo T., Free PMC Article | 12/8/2012 |
| These results show that intracellular levels of Spt6 are fine-tuned by PAAF1 and proteasome, which is required for HIV-1 transcription and extends to cellular genes implicated in cancer. | Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR.
Nakamura M, Basavarajaiah P, Rousset E, Beraud C, Latreille D, Henaoui IS, Lassot I, Mari B, Kiernan R., Free PMC Article | 05/19/2012 |
| Abolishing UL69's ability to interact with the SPT6 protein inhibited human cytomegalovirus replication. | The cellular protein SPT6 is required for efficient replication of human cytomegalovirus.
Cygnar D, Hagemeier S, Kronemann D, Bresnahan WA., Free PMC Article | 03/24/2012 |
| Knockdown of Spt6 resulted in severe reduction of class switch recombination in the endogenous Ig locus in B cells. | Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.
Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, Honjo T., Free PMC Article | 07/16/2011 |
| Reults establish that human Spt6 (hSpt6) is a classic transcription elongation factor that enhances the rate of RNA polymerase II elongation. | Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro.
Endoh M, Zhu W, Hasegawa J, Watanabe H, Kim DK, Aida M, Inukai N, Narita T, Yamada T, Furuya A, Sato H, Yamaguchi Y, Mandal SS, Reinberg D, Wada T, Handa H., Free PMC Article | 01/21/2010 |