| RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork. | RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork.
Hayran AB, Liabakk NB, Aas PA, Kusnierczyk A, Vågbø CB, Sarno A, Iveland TS, Chawla K, Zahn A, Di Noia JM, Slupphaug G, Kavli B., Free PMC Article | 02/1/2024 |
| Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis. | Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis.
Song J, Zhang X, Yin Y, Guo M, Zhao X, Wang L, Ren C, Yin Y, Zhang X, Deng X, Lu D., Free PMC Article | 04/19/2023 |
| The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates. | The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates.
Hinch AG, Becker PW, Li T, Moralli D, Zhang G, Bycroft C, Green C, Keeney S, Shi Q, Davies B, Donnelly P., Free PMC Article | 09/26/2020 |
| localization of the replication protein A (RPA) complex on the chromosome axes meiotic prophase in mouse spermatocytes, is reported. | Structured illumination microscopy imaging reveals localization of replication protein A between chromosome lateral elements during mammalian meiosis.
Yoon S, Choi EH, Kim JW, Kim KP., Free PMC Article | 05/18/2019 |
| Using an inducible germline-specific inactivation strategy, we find that loss of RPA completely abrogates loading of RAD51/DMC1 recombinases to programmed meiotic DNA double strand breaks, thus blocking strand invasion required for chromosome pairing and synapsis. | Dual functions for the ssDNA-binding protein RPA in meiotic recombination.
Shi B, Xue J, Yin H, Guo R, Luo M, Ye L, Shi Q, Huang X, Liu M, Sha J, Wang PJ., Free PMC Article | 04/20/2019 |
| The recovery of abnormal phenotypes of mutant Ataxin-1 knock-in (Atxn1-KI) mice in the dendrite and spine morphology of Purkinje cells by AAV vector-mediated expression of RpA1 was reported. | RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair.
Taniguchi JB, Kondo K, Fujita K, Chen X, Homma H, Sudo T, Mao Y, Watase K, Tanaka T, Tagawa K, Tamura T, Muramatsu SI, Okazawa H. | 03/3/2018 |
| The authors establish that a second Dna2-Rpa interaction is mutually exclusive with Rpa-DNA interactions and mediates the displacement of Rpa from ssDNA. | Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.
Zhou C, Pourmal S, Pavletich NP., Free PMC Article | 09/3/2016 |
| LT prevents recruitment of RPA to nuclear foci after DNA damage. This leads to failure to recruit repair proteins such as Rad51 or Rad9, explaining why LT prevents repair of double strand DNA breaks by homologous recombination. | Viral interference with DNA repair by targeting of the single-stranded DNA binding protein RPA.
Banerjee P, DeJesus R, Gjoerup O, Schaffhausen BS., Free PMC Article | 09/6/2014 |
| Most RPA recruitment during class switch recombination represents salvage of unrepaired breaks by homology-based pathways during the S-G2/M phase of the cell cycle. | RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle.
Yamane A, Robbiani DF, Resch W, Bothmer A, Nakahashi H, Oliveira T, Rommel PC, Brown EJ, Nussenzweig A, Nussenzweig MC, Casellas R., Free PMC Article | 07/20/2013 |
| POT1a degradation resulted in rapid and reversible activation of the ATR pathway in G1 and S/G2. | A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion.
Gong Y, de Lange T., Free PMC Article | 01/1/2011 |
| Rpa1(L230P) missense mutation significantly alters the tumor phenotype and spectrum of Trp53 mutant mice by modifying the genetic mechanisms underlying tumorigenesis. | Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.
Wang Y, Zhang W, Edelmann L, Kolodner RD, Kucherlapati R, Edelmann W., Free PMC Article | 04/19/2010 |
| hyperphosphorylation may play a role in modulating cellular pathways by altering the DNA binding domain-mediated RPA-DNA and RPA-protein interactions, hypothetically via the interaction of hyperphosphorylated RPA32N with DBD-B | Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B.
Liu Y, Kvaratskhelia M, Hess S, Qu Y, Zou Y., Free PMC Article | 01/21/2010 |
| Rpa1 functions in DNA metabolism are essential for the maintenance of chromosomal stability and tumor suppression. | Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice.
Wang Y, Putnam CD, Kane MF, Zhang W, Edelmann L, Russell R, Carrión DV, Chin L, Kucherlapati R, Kolodner RD, Edelmann W. | 01/21/2010 |
| both TNFR-p55 and TNFR-p75 appear to be of minimal importance for modulation of Fas-mediated apoptosis and associated A1 protein expression despite normal Fas/TNFR-p55 and increased TNFR-p75 expression in neutrophils | Fas-mediated neutrophil apoptosis and associated A1 protein expression during systemic inflammation are regulated independently of both tumor necrosis factor receptors.
Kotani J, Avallone NJ, Lin E, Goshima M, Gandhi K, Lowry SF, Calvano SE. | 01/21/2010 |
| These results demonstrate that neither RPA hyper-phosphorylation nor H2AX are required for the formation in RPA intra-nuclear foci in response to DNA damage/replicational stress. | DNA damage-induced RPA focalization is independent of gamma-H2AX and RPA hyper-phosphorylation.
Liu JS, Kuo SR, Melendy T. | 01/21/2010 |