| An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness. | An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness.
Peng H, Feng K, Jia W, Li Y, Lv Q, Zhang Y. | 06/17/2024 |
| 3-Epi-25-hydroxyvitamin D3 is a poor substrate for SULT2A1: Analysis of its 3-sulfate in cord plasma and recombinant human SULT2A1 incubate. | 3-Epi-25-hydroxyvitamin D(3) is a poor substrate for SULT2A1: Analysis of its 3-sulfate in cord plasma and recombinant human SULT2A1 incubate.
Yoshimura Y, Togashi M, Ogawa S, Higashi T. | 06/19/2021 |
| Energy-dependent scoring of docking solutions identified the interaction as specific for the PAPSS2 and SULT2A1 isoforms | Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1.
Mueller JW, Idkowiak J, Gesteira TF, Vallet C, Hardman R, van den Boom J, Dhir V, Knauer SK, Rosta E, Arlt W., Free PMC Article | 01/26/2019 |
| Kinetic analyses showed further differential catalytic efficiency and substrate affinity of the SULT2A1 allozymes, in comparison with wild-type SULT2A1. These findings provided useful information concerning the effects of genetic polymorphisms on the sulfating activity of SULT2A1 allozymes. | Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A1.
Abunnaja MS, Alherz FA, El Daibani AA, Bairam AF, Rasool MI, Gohal SA, Kurogi K, Suiko M, Sakakibara Y, Liu MC. | 12/1/2018 |
| Polymorphisms of SULT2A1 gene is not associated with attention-deficit/hyperactivity disorder. | Polymorphisms of STS gene and SULT2A1 gene and neurosteroid levels in Han Chinese boys with attention-deficit/hyperactivity disorder: an exploratory investigation.
Wang LJ, Chan WC, Chou MC, Chou WJ, Lee MJ, Lee SY, Lin PY, Yang YH, Yen CF., Free PMC Article | 11/17/2018 |
| Galeterone and abiraterone are novel inhibitors of DHEA sulfonation, as determined in enzymatic incubations containing human tissue cytosol (liver or intestinal) or human recombinant SULT enzyme (SULT2A1, SULT2B1b, or SULT1E1). | Identification of Galeterone and Abiraterone as Inhibitors of Dehydroepiandrosterone Sulfonation Catalyzed by Human Hepatic Cytosol, SULT2A1, SULT2B1b, and SULT1E1.
Yip CKY, Bansal S, Wong SY, Lau AJ. | 11/10/2018 |
| nine human SULT2A1 allozymes plus the wild-type SULT2A1 were found to display differential sulfating activity toward DHEA and tibolone. Kinetic analysis revealed that different SULT2A1 allozymes exhibited differential substrate affinity and catalytic efficiency toward the two substrates tested. | Effects of Human Sulfotransferase 2A1 Genetic Polymorphisms 3 on the Sulfation of Tibolone.
Miller E, Zalzala MH, Abunnaja MS, Kurogi K, Sakakibara Y, Suiko M, Liu MC., Free PMC Article | 10/27/2018 |
| Mass spectrometry analysis and structural modeling supported a reaction mechanism which involves the isomerization of Delta(4)-3-ketosteroids from the keto form to an enol form, prior to being subjected to sulfation. Results derived from this study suggested a potential role of SULT2A1 as a Delta(4)-3-ketosteroid sulfotransferase in steroid metabolism | Δ(4)-3-ketosteroids as a new class of substrates for the cytosolic sulfotransferases.
Hashiguchi T, Kurogi K, Shimohira T, Teramoto T, Liu MC, Suiko M, Sakakibara Y., Free PMC Article | 02/10/2018 |
| A theoretical study at the level of density functional theory (DFT) was performed to characterize noncovalent intermolecular interactions, especially hydrogen bond interactions, in the active site of enzyme human androsterone sulphotransferase. | A theoretical study on the characteristics of the intermolecular interactions in the active site of human androsterone sulphotransferase: DFT calculations of NQR and NMR parameters and QTAIM analysis.
Astani EK, Heshmati E, Chen CJ, Hadipour NL. | 02/3/2018 |
| Decreased SULT2A1 activity was found in the adrenal zona reticularis in Alzheimer's disease patients. | Reduced sulfotransferase SULT2A1 activity in patients with Alzheimer's disease.
Vaňková M, Hill M, Velíková M, Včelák J, Vacínová G, Lukášová P, Vejražková D, Dvořáková K, Rusina R, Holmerová I, Jarolímová E, Vaňková H, Bendlová B. | 10/1/2016 |
| PSC is characterized by disease-specific impairment of SULT2A1 expression following PXR activation, a phenomenon which is not noted in PBC, and may account for the impaired hepatoprotection in PSC. | Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR.
Wunsch E, Klak M, Wasik U, Milkiewicz M, Blatkiewicz M, Urasinska E, Barbier O, Bielicki D, Bogdanos DP, Elias E, Milkiewicz P., Free PMC Article | 05/28/2016 |
| It metabolizes breast cancer drugs like afinoxifene and endoxifen by sulfation. | Sulfation of afimoxifene, endoxifen, raloxifene, and fulvestrant by the human cytosolic sulfotransferases (SULTs): A systematic analysis.
Hui Y, Luo L, Zhang L, Kurogi K, Zhou C, Sakakibara Y, Suiko M, Liu MC. | 05/14/2016 |
| The substrate, such as lithocholic acid (LCA), participated in regulating the structure and flexibility of sulfotransferase actively rather than merely being selected passively. | The impact of ligands on the structure and flexibility of sulfotransferases: a molecular dynamics simulation study.
Zhao L, Zhang P, Long S, Wang L, Tian P. | 05/7/2016 |
| Our results show that SULT2A1 is important in the first trimester; particularly in the adrenals | Genetic variation, expression and ontogeny of sulfotransferase SULT2A1 in humans.
Ekström L, Rane A. | 04/23/2016 |
| molecular dynamic simulations were used to investigate the effect of ligands (cofactor and substrate) on the thermo-denaturation process of hSULT2A1 | The effect of ligands on the thermal stability of sulfotransferases: a molecular dynamics simulation study.
Zhang PP, Zhao L, Long SY, Tian P. | 11/28/2015 |
| results established human SULT2A1 as a novel LXRalpha target gene; the expression of LXRalpha is a potential predictor for the expression of SULT2A1 in human liver | Transcriptional regulation of human hydroxysteroid sulfotransferase SULT2A1 by LXRα.
Ou Z, Jiang M, Hu B, Huang Y, Xu M, Ren S, Li S, Liu S, Xie W, Huang M., Free PMC Article | 05/30/2015 |
| It turns out the protective effect of DHEA was significantly decreased when Wnt/beta-catenin signaling was activated, while inactivating Wnt/beta-catenin signaling enhanced the effects of DHEA | A possible mechanism in DHEA-mediated protection against osteoarthritis.
Li WJ, Tang LP, Xiong Y, Chen WP, Zhou XD, Ding QH, Wu LD. | 05/30/2015 |
| The complete kinetic mechanism of human SULT2A1. | Paradigms of sulfotransferase catalysis: the mechanism of SULT2A1.
Wang T, Cook I, Falany CN, Leyh TS., Free PMC Article | 02/7/2015 |
| Fetal inflammatory response syndrome and funisitis are associated with an elevation of umbilical cord plasma concentrations of soluble sulfotransferase (ST)2. | Soluble ST2 in the fetal inflammatory response syndrome: in vivo evidence of activation of the anti-inflammatory limb of the immune response.
Stampalija T, Romero R, Korzeniewski SJ, Chaemsaithong P, Miranda J, Yeo L, Dong Z, Hassan SS, Chaiworapongsa T., Free PMC Article | 04/5/2014 |
| Depression following hip fracture with poor long term recovery is associated with a higher serum cortisol:DHEAS ratio. | Depression following hip fracture is associated with increased physical frailty in older adults: the role of the cortisol: dehydroepiandrosterone sulphate ratio.
Phillips AC, Upton J, Duggal NA, Carroll D, Lord JM., Free PMC Article | 02/15/2014 |
| Genetic variants in SULT2A1 do not predispose to polycystic ovary syndrome. Although a variant in SULT2A1 decreased the DHEAS to DHEA ratio, no changes in other androgenic hormone levels were observed. | Variants in SULT2A1 affect the DHEA sulphate to DHEA ratio in patients with polycystic ovary syndrome but not the hyperandrogenic phenotype.
Louwers YV, de Jong FH, van Herwaarden NA, Stolk L, Fauser BC, Uitterlinden AG, Laven JS. | 11/16/2013 |
| formation of disulfide bonds in hSULT2A1 is a potentially important reversible mechanism for alterations in the rates of sulfation of both endogenous and xenobiotic substrates | Modification of the catalytic function of human hydroxysteroid sulfotransferase hSULT2A1 by formation of disulfide bonds.
Qin X, Teesch LM, Duffel MW., Free PMC Article | 11/2/2013 |
| These data show an age-related association of polymorphisms in the SULT2A1 gene with lower dehydroepiandrosterone sulfate, suggesting that these polymorphisms may affect dehydroepiandrosterone sulfate concentration in adults. | Relationship between polymorphisms in the sulfotransferase SULT2A1 gene and dehydroepiandrosterone sulfate concentration in children.
García-Anguita A, Ortega L, Garcés C. | 06/15/2013 |
| SULT2A1 as a novel ROR-alpha and ROR-gamma target gene. | Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases.
Ou Z, Shi X, Gilroy RK, Kirisci L, Romkes M, Lynch C, Wang H, Xu M, Jiang M, Ren S, Gramignoli R, Strom SC, Huang M, Xie W., Free PMC Article | 06/8/2013 |
| Genetic variants of SULT2A1 do not appear to have an effect on individual DHEA and DHEAS concentrations or the DHEA/DHEAS ratio as a marker of DHEA sulfonation capacity | A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio.
Haring R, Wallaschofski H, Teumer A, Kroemer H, Taylor AE, Shackleton CH, Nauck M, Völker U, Homuth G, Arlt W., Free PMC Article | 06/8/2013 |