| The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress. | The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
Jeong DJ, Um JH, Kim YY, Shin DJ, Im S, Lee KM, Lee YH, Lim DS, Kim D, Yun J., Free PMC Article | 04/11/2024 |
| Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions. | Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions.
Xu Y, Qu M, He Y, He Q, Shen T, Luo J, Tan D, Bao H, Xu C, Ji X, Hu X, Barkat MQ, Zeng LH, Wu X., Free PMC Article | 01/9/2024 |
| MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression. | MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression.
Sun Y, Jin X, Meng J, Guo F, Chen T, Zhao X, Wu H, Ren D., Free PMC Article | 12/5/2023 |
| The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation. | The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation.
Wang Y, Risteski P, Yang Y, Chen H, Droby G, Walens A, Jayaprakash D, Troester M, Herring L, Chernoff J, Tolić IM, Bowser J, Vaziri C., Free PMC Article | 11/2/2023 |
| TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2. | TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2.
Liu YX, Wan S, Yang XQ, Wang Y, Gan WJ, Ye WL, He XS, Chen JJ, Yang Y, Yang XM, Guo X, Gao XJ, Lu YT, Deng ZY, Hu G, Wu H. | 08/3/2023 |
| Mammalian STE20-like kinase-1/2 are activated in human platelets stimulated by collagen or thrombin and play a vital role in collagen-activated platelets. | Mammalian STE20-like kinase-1/2 are activated in human platelets stimulated by collagen or thrombin and play a vital role in collagen-activated platelets.
Qiao C, Jiang P, Yuan X, Su N, Sun P, Lin F. | 01/7/2023 |
| Extracellular matrix stiffness regulates degradation of MST2 via SCF <sup>betaTrCP</sup>. | Extracellular matrix stiffness regulates degradation of MST2 via SCF (βTrCP).
Fiore APZP, Rodrigues AM, Ribeiro-Filho HV, Manucci AC, de Freitas Ribeiro P, Botelho MCS, Vogel C, Lopes-de-Oliveira PS, Pagano M, Bruni-Cardoso A., Free PMC Article | 11/12/2022 |
| Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma. | Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma.
Romano D, García-Gutiérrez L, Aboud N, Duffy DJ, Flaherty KT, Frederick DT, Kolch W, Matallanas D., Free PMC Article | 09/3/2022 |
| MST1/2 in PDGFRalpha(+) cells negatively regulates TGF-beta-induced myofibroblast accumulation in renal fibrosis. | MST1/2 in PDGFRα(+) cells negatively regulates TGF-β-induced myofibroblast accumulation in renal fibrosis.
An Y, Ren Y, Wang J, Zang J, Gao M, Wang H, Wang S, Dong Y. | 08/6/2022 |
| High MST2 expression regulates lens epithelial cell apoptosis in age-related cataracts through YAP1 targeting GLUT1. | High MST2 expression regulates lens epithelial cell apoptosis in age-related cataracts through YAP1 targeting GLUT1.
Liu S, Su D, Sun Z, Guan L, Wang Z, Zhang G, Zheng G, Cui T, Ma X, Hu S. | 05/14/2022 |
| Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer. | Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.
Schirmer AU, Driver LM, Zhao MT, Wells CI, Pickett JE, O'Bryne SN, Eduful BJ, Yang X, Howard L, You S, Devi GR, DiGiovanni J, Freedland SJ, Chi JT, Drewry DH, Macias E., Free PMC Article | 04/16/2022 |
| Regulation of MST complexes and activity via SARAH domain modifications. | Regulation of MST complexes and activity via SARAH domain modifications.
Karchugina S, Benton D, Chernoff J., Free PMC Article | 01/29/2022 |
| STK3 Suppresses Ovarian Cancer Progression by Activating NF-kappaB Signaling to Recruit CD8(+) T-Cells. | STK3 Suppresses Ovarian Cancer Progression by Activating NF-κB Signaling to Recruit CD8(+) T-Cells.
Wang X, Wang F, Zhang ZG, Yang XM, Zhang R., Free PMC Article | 07/17/2021 |
| PIN1 facilitates ubiquitin-mediated degradation of serine/threonine kinase 3 and promotes melanoma development via TAZ activation. | PIN1 facilitates ubiquitin-mediated degradation of serine/threonine kinase 3 and promotes melanoma development via TAZ activation.
Kim G, Bhattarai PY, Lim SC, Kim JY, Choi HS. | 05/22/2021 |
| Fascin Regulates the Hippo Pathway and Is Important for Melanoma Development. | Fascin Regulates the Hippo Pathway and Is Important for Melanoma Development.
Kang BS, Lim SC. | 05/22/2021 |
| STK3/STK4 signalling in adipocytes regulates mitophagy and energy expenditure. | STK3/STK4 signalling in adipocytes regulates mitophagy and energy expenditure.
Cho YK, Son Y, Saha A, Kim D, Choi C, Kim M, Park JH, Im H, Han J, Kim K, Jung YS, Yun J, Bae EJ, Seong JK, Lee MO, Lee S, Granneman JG, Lee YH. | 04/24/2021 |
| Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling. | Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling.
Tran T, Mitra J, Ha T, Kavran JM., Free PMC Article | 03/13/2021 |
| MST2 silencing induces apoptosis and inhibits tumor growth for estrogen receptor alpha-positive MCF-7 breast cancer. | MST2 silencing induces apoptosis and inhibits tumor growth for estrogen receptor alpha-positive MCF-7 breast cancer.
Park J, Kim GH, Lee J, Phuong BTC, Kong B, Won JE, Won GW, Lee YH, Han HD, Lee Y. | 01/16/2021 |
| RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA. | RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA.
Wu X, Wang Y, Zhong W, Cheng H, Tian Z., Free PMC Article | 12/5/2020 |
| FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. | FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis.
Turunen SP, von Nandelstadh P, Öhman T, Gucciardo E, Seashore-Ludlow B, Martins B, Rantanen V, Li H, Höpfner K, Östling P, Varjosalo M, Lehti K., Free PMC Article | 10/3/2020 |
| The results show that the noncanonical Hippo MST2-FoxO3a-DeltaNp63alpha pathway may play a critical role in ROS-mediated regulation of cell migration and tumor metastasis. | Hippo kinases regulate cell junctions to inhibit tumor metastasis in response to oxidative stress.
Wang Y, Li J, Gao Y, Luo Y, Luo H, Wang L, Yi Y, Yuan Z, Jim Xiao ZX., Free PMC Article | 02/29/2020 |
| BCL-2 is a new regulator of MST pathway. First, protein levels of MST2 and SAV1 were reduced significantly by co-expression of BCL-2. Physical interaction of BCL-2 with SAV1 was correlated with proteasomal degradation of SAV1 and MST2 proteins. | Mammalian Hippo kinase pathway is downregulated by BCL-2 via protein degradation.
Won GW, Park SH, Park J, Lee Y, Lee YH. | 02/15/2020 |
| The activation segment of NDR1 influences interaction with MST1/MST2 and Furry. | Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F., Free PMC Article | 08/10/2019 |
| MST2 kinase localises at the nucleoli and targets phosphorylation of H2BS14p in an ATM-dependent manner. Ablation of MST2 kinase, or upstream activators, results in defective establishment of nucleolar H2BS14p, perturbed DNA damage repair, sensitisation to rDNA damage and increased cell lethality. | MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B.
Pefani DE, Tognoli ML, Pirincci Ercan D, Gorgoulis V, O'Neill E., Free PMC Article | 04/20/2019 |
| These results suggest Salvador enhances the effects of Hippo kinase activity at multiple points in the Hippo pathway. | Salvador has an extended SARAH domain that mediates binding to Hippo kinase.
Cairns L, Tran T, Fowl BH, Patterson A, Kim YJ, Bothner B, Kavran JM., Free PMC Article | 12/22/2018 |