| Depletion of Ppp6c in hematopoietic and vascular endothelial cells causes embryonic lethality and decreased hematopoietic potential. | Depletion of Ppp6c in hematopoietic and vascular endothelial cells causes embryonic lethality and decreased hematopoietic potential.
Kondo A, Tanaka H, Rai S, Shima H, Matsumura I, Watanabe T. | 06/8/2024 |
| Oncogenic K-Ras[G12V] cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts. | Oncogenic K-Ras(G12V) cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
Ito M, Tanuma N, Kotani Y, Murai K, Kondo A, Sumiyoshi M, Shima H, Matsuda S, Watanabe T., Free PMC Article | 04/16/2024 |
| Neuron-specific loss of Ppp6c induces neonatal death and decreases the number of cortical neurons and interneurons. | Neuron-specific loss of Ppp6c induces neonatal death and decreases the number of cortical neurons and interneurons.
Matsuoka M, Sakai D, Shima H, Watanabe T. | 01/12/2024 |
| Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1. | Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1.
Zou Y, Zheng Q, Jiang B, Liu Y, Xu Y, Ma L, Hu Z, Wu M, Song H., Free PMC Article | 07/30/2022 |
| PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features. | PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.
Fukui K, Nomura M, Kishimoto K, Tanuma N, Kurosawa K, Kanazawa K, Kato H, Sato T, Miura S, Miura K, Sato I, Tsuji H, Yamashita Y, Tamai K, Watanabe T, Yasuda J, Tanaka T, Satoh K, Furukawa T, Jingu K, Shima H., Free PMC Article | 05/28/2022 |
| Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis. | Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis.
Lei WL, Li YY, Meng TG, Ning Y, Sun SM, Zhang CH, Gui Y, Wang ZB, Qian WP, Sun QY., Free PMC Article | 02/5/2022 |
| Ppp6c deficiency accelerates K-ras(G12D) -induced tongue carcinogenesis. | Ppp6c deficiency accelerates K-ras(G12D) -induced tongue carcinogenesis.
Kishimoto K, Kanazawa K, Nomura M, Tanaka T, Shigemoto-Kuroda T, Fukui K, Miura K, Kurosawa K, Kawai M, Kato H, Terasaki K, Sakamoto Y, Yamashita Y, Sato I, Tanuma N, Tamai K, Kitabayashi I, Matsuura K, Watanabe T, Yasuda J, Tsuji H, Shima H., Free PMC Article | 01/1/2022 |
| Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis. | Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.
Kanazawa K, Kishimoto K, Nomura M, Kurosawa K, Kato H, Inoue Y, Miura K, Fukui K, Yamashita Y, Sato I, Tsuji H, Watanabe T, Tanaka T, Yasuda J, Tanuma N, Shima H., Free PMC Article | 06/19/2021 |
| Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response. | Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
Li M, Shu HB., Free PMC Article | 02/13/2021 |
| Ppp6c deficiency enhances K-ras(G12D) -dependent tumor promotion | Loss of protein phosphatase 6 in mouse keratinocytes enhances K-ras(G12D) -driven tumor promotion.
Kurosawa K, Inoue Y, Kakugawa Y, Yamashita Y, Kanazawa K, Kishimoto K, Nomura M, Momoi Y, Sato I, Chiba N, Suzuki M, Ogoh H, Yamada H, Miura K, Watanabe T, Tanuma N, Tachi M, Shima H., Free PMC Article | 07/28/2018 |
| the Ppp6c phosphatase domain is indispensable for mouse embryogenesis after implantation. | The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis.
Ogoh H, Tanuma N, Matsui Y, Hayakawa N, Inagaki A, Sumiyoshi M, Momoi Y, Kishimoto A, Suzuki M, Sasaki N, Ohuchi T, Nomura M, Teruya Y, Yasuda K, Watanabe T, Shima H. | 12/17/2016 |
| findings uncover a hitherto unknown role for PP6 as an indispensable regulator of oocyte meiosis and female fertility. | Loss of protein phosphatase 6 in oocytes causes failure of meiosis II exit and impaired female fertility.
Hu MW, Wang ZB, Teng Y, Jiang ZZ, Ma XS, Hou N, Cheng X, Schatten H, Xu X, Yang X, Sun QY. | 08/27/2016 |
| Data identify NF-kappaB-induced miR-31 and its target, ppp6c, as critical factors for the hyperproliferation of epidermis in psoriasis. | NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis.
Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu XZ, Zheng Y, Shen N, Chin YE, Wang H., Free PMC Article | 04/16/2016 |
| Ppp6c deficiency predisposes mice to skin carcinogenesis initiated by DMBA. | Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA.
Hayashi K, Momoi Y, Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonari H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, Shima H. | 11/28/2015 |
| Ppp6c deficiency underlies molecular events that drive outgrowth of initiated keratinocytes harboring UVB-induced mutated p53 | Loss of protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis.
Kato H, Kurosawa K, Inoue Y, Tanuma N, Momoi Y, Hayashi K, Ogoh H, Nomura M, Sakayori M, Kakugawa Y, Yamashita Y, Miura K, Maemondo M, Katakura R, Ito S, Sato M, Sato I, Chiba N, Watanabe T, Shima H. | 10/3/2015 |
| Our studies demonstrate that PP6 acts as a critical negative regulator of naive T cell homeostasis | PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling.
Ye J, Shi H, Shen Y, Peng C, Liu Y, Li C, Deng K, Geng J, Xu T, Zhuang Y, Zheng B, Tao W. | 04/25/2015 |
| PP6 regulates the sensitivity of GBM cells to radiation, and suggest small molecules disrupting or inhibiting PP6 association with DNA-PK is a potential radiosensitizer for GBM. | Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma.
Shen Y, Wang Y, Sheng K, Fei X, Guo Q, Larner J, Kong X, Qiu Y, Mi J., Free PMC Article | 03/17/2012 |
| alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A and PP6 [PP6] | The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.
Prickett TD, Brautigan DL. | 01/21/2010 |