| GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity. | GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity.
Tang M, Zhang Y, Zhang R, Zhang Y, Zheng J, Wang D, Wang X, Yan J, Hu C., Free PMC Article | 02/1/2024 |
| AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis. | AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis.
Descovich CP, Lough KJ, Jena A, Wu JJ, Yom J, Spitzer DC, Uppalapati M, Kedziora KM, Williams SE., Free PMC Article | 04/20/2023 |
| GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages. | GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages.
Yan J, Zhang Y, Yu H, Zong Y, Wang D, Zheng J, Jin L, Yu X, Liu C, Zhang Y, Jiang F, Zhang R, Fang X, Xu T, Li M, Di J, Lu Y, Ma X, Zhang J, Jia W, Hu C., Free PMC Article | 12/17/2022 |
| AGS3-dependent trans-Golgi network membrane trafficking is essential for compaction in mouse embryos. | AGS3-dependent trans-Golgi network membrane trafficking is essential for compaction in mouse embryos.
Nie ZW, Niu YJ, Zhou W, Zhou DJ, Kim JY, Cui XS. | 07/10/2021 |
| Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function. | Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function.
Ding Q, Tan ALM, Parra EJ, Cruz M, Sim X, Teo YY, Long J, Alsafar H, Petretto E, Tai ES, Chen H. | 10/10/2020 |
| findings show that AGS3 is not required for planar divisions of neural progenitors in the mouse neocortex. AGS3 is not recruited to the cell cortex and does not rescue LGN loss of function. | Loss of the canonical spindle orientation function in the Pins/LGN homolog AGS3.
Saadaoui M, Konno D, Loulier K, Goiame R, Jadhav V, Mapelli M, Matsuzaki F, Morin X., Free PMC Article | 04/21/2018 |
| We conclude that LPS priming increases AGS3 levels, which enhances lysosomal function and increases the capacity of macrophages to eliminate intracellular pathogens. | Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection.
Vural A, Al-Khodor S, Cheung GY, Shi CS, Srinivasan L, McQuiston TJ, Hwang IY, Yeh AJ, Blumer JB, Briken V, Williamson PR, Otto M, Fraser ID, Kehrl JH., Free PMC Article | 05/28/2016 |
| level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3, AGS3, or RGS19; or had been treated with pertussis toxin, were similar to controls | Normal autophagic activity in macrophages from mice lacking Gαi3, AGS3, or RGS19.
Vural A, McQuiston TJ, Blumer JB, Park C, Hwang IY, Williams-Bey Y, Shi CS, Ma DZ, Kehrl JH., Free PMC Article | 08/9/2014 |
| AGS3 has a role in the regulation of G-protein signaling in the immune system | Defective chemokine signal integration in leukocytes lacking activator of G protein signaling 3 (AGS3).
Branham-O'Connor M, Robichaux WG 3rd, Zhang XK, Cho H, Kehrl JH, Lanier SM, Blumer JB., Free PMC Article | 06/21/2014 |
| these results indicate that GRK6 complexes with AGS3-Galphai2 to regulate CXCR2-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane. | G Protein-coupled receptor kinase-6 interacts with activator of G protein signaling-3 to regulate CXCR2-mediated cellular functions.
Singh V, Raghuwanshi SK, Smith N, Rivers EJ, Richardson RM., Free PMC Article | 04/19/2014 |
| The present study demonstrates an important role for GPSM1 in controlling the dynamics of cyst progression in an orthologous mouse model of autosomal dominant polycystic kidney disease. | G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease.
Kwon M, Pavlov TS, Nozu K, Rasmussen SA, Ilatovskaya DV, Lerch-Gaggl A, North LM, Kim H, Qian F, Sweeney WE Jr, Avner ED, Blumer JB, Staruschenko A, Park F., Free PMC Article | 02/23/2013 |
| These data suggest that Gpsm1 acts through a novel receptor-independent mechanism to facilitate renal tubular epithelial cell proliferation and renal tubular regeneration. | Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents.
Regner KR, Nozu K, Lanier SM, Blumer JB, Avner ED, Sweeney WE Jr, Park F., Free PMC Article | 08/20/2011 |
| AGS3 null mice exhibited a lean phenotype, reduced fat mass, and increased nocturnal energy expenditure. | Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function.
Blumer JB, Lord K, Saunders TL, Pacchioni A, Black C, Lazartigues E, Varner KJ, Gettys TW, Lanier SM., Free PMC Article | 01/21/2010 |
| cortical localization in mitotic cell culture systems and requirement for normal cell cycle progression | Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression.
Kaushik R, Yu F, Chia W, Yang X, Bahri S., Free PMC Article | 01/21/2010 |
| The GPR motif in this protein and other proteins is actually associated with activity as a GDI - guanine nucleotide dissociation inhibitor and not GTPase activator as initially suggested. | Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3.
Peterson YK, Bernard ML, Ma H, Hazard S 3rd, Graber SG, Lanier SM. | 12/22/2003 |