| Variants in NLRP2 and ZFP36L2, non-core components of the human subcortical maternal complex, cause female infertility with embryonic development arrest. | Variants in NLRP2 and ZFP36L2, non-core components of the human subcortical maternal complex, cause female infertility with embryonic development arrest.
Rui X, Zhang X, Jia X, Han J, Wang C, Cao Q, Zhong O, Ding J, Zhao C, Zhang J, Ling X, Li H, Ma X, Meng Q, Huo R. | 11/6/2024 |
| Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes. | Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes.
Sun J, Li M, Sun H, Lin Z, Shi B, Jia Z. | 03/29/2024 |
| A novel homozygous variant in ZFP36L2 cause female infertility due to oocyte maturation defect. | A novel homozygous variant in ZFP36L2 cause female infertility due to oocyte maturation defect.
Zhou Z, Fan H, Shi R, Zeng Y, Liu R, Gu H, Li Q, Sang Q, Wang L, Shi J, Chen B. | 09/8/2023 |
| TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2. | TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2.
Balducci E, Steimlé T, Smith C, Villarese P, Feroul M, Payet-Bornet D, Kaltenbach S, Couronné L, Lhermitte L, Touzart A, Dourthe ME, Simonin M, Baruchel A, Dombret H, Ifrah N, Boissel N, Nadel B, Macintyre E, Cieslak A, Asnafi V., Free PMC Article | 07/17/2023 |
| The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells. | The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells.
Novosad VO, Maltseva DV. | 06/29/2023 |
| Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest. | Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest.
Zheng W, Sha QQ, Hu H, Meng F, Zhou Q, Chen X, Zhang S, Gu Y, Yan X, Zhao L, Zong Y, Hu L, Gong F, Lu G, Fan HY, Lin G. | 08/27/2022 |
| Genomic evolution and diverse models of systemic metastases in colorectal cancer. | Genomic evolution and diverse models of systemic metastases in colorectal cancer.
Chen HN, Shu Y, Liao F, Liao X, Zhang H, Qin Y, Wang Z, Luo M, Liu Q, Xue Z, Cao M, Zhang S, Zhang WH, Hou Q, Xia X, Luo H, Zhang Y, Yang L, Hu JK, Fu X, Liu B, Hu H, Huang C, Peng Y, Cheng W, Dai L, Yang L, Zhang W, Dong B, Li Y, Wei Y, Xu H, Zhou ZG., Free PMC Article | 03/12/2022 |
| ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts. | ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.
Angiolilli C, Leijten EFA, Bekker CPJ, Eeftink E, Giovannone B, Nordkamp MO, van der Wal M, Thijs JL, Vastert SJ, van Wijk F, Radstake TRDJ, van Loosdregt J. | 02/5/2022 |
| Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells. | Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells.
Che Mat MF, Mohamad Hanif EA, Abdul Murad NA, Ibrahim K, Harun R, Jamal R. | 06/5/2021 |
| RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells. | RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.
Makita S, Takatori H, Iwata A, Tanaka S, Furuta S, Ikeda K, Suto A, Suzuki K, Ramos SBV, Nakajima H., Free PMC Article | 04/3/2021 |
| The results indicated that ZFP36L1 and ZFP36L2 play a negative role in cell proliferation; the underlying mechanisms might be mediated through a cyclin D-dependent and p53-independent pathway. | ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner.
Suk FM, Chang CC, Lin RJ, Lin SY, Liu SC, Jau CF, Liang YC., Free PMC Article | 09/21/2019 |
| Study describe diverse models of structural variations and affected genes in gastric cancer, of which we unveil a tandem-duplications hotspot involving the coding sequence and super-enhancer region of zinc finger protein 36 ring-finger protein-like 2 (ZFP36L2). | Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer.
Xing R, Zhou Y, Yu J, Yu Y, Nie Y, Luo W, Yang C, Xiong T, Wu WKK, Li Z, Bing Y, Lin S, Zhang Y, Hu Y, Li L, Han L, Yang C, Huang S, Huang S, Zhou R, Li J, Wu K, Fan D, Tang G, Dou J, Zhu Z, Ji J, Fang X, Lu Y., Free PMC Article | 06/15/2019 |
| ZFP36L2 could be transactivated by AML1, which subsequently induced cell-cycle arrest and apoptosis of leukemia cells | ZFP36L2, a novel AML1 target gene, induces AML cells apoptosis and inhibits cell proliferation.
Liu J, Lu W, Liu S, Wang Y, Li S, Xu Y, Xing H, Tang K, Tian Z, Rao Q, Wang M, Wang J. | 04/6/2019 |
| Significantly mutated gene ZFP36L2 displayed strong antiproliferation function in Esophageal Squamous Cell Carcinoma but not in Esophageal Adenocarcinomas. | Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas.
Lin DC, Dinh HQ, Xie JJ, Mayakonda A, Silva TC, Jiang YY, Ding LW, He JZ, Xu XE, Hao JJ, Wang MR, Li C, Xu LY, Li EM, Berman BP, Phillip Koeffler H., Free PMC Article | 09/22/2018 |
| silencing ZFP36L2 inhibited cancer cell aggressiveness in pancreatic ductal adenocarcinoma cell lines, and overexpression of ZFP36L2 was confirmed in pancreatic ductal adenocarcinoma clinical specimens | ZFP36L2 promotes cancer cell aggressiveness and is regulated by antitumor microRNA-375 in pancreatic ductal adenocarcinoma.
Yonemori K, Seki N, Kurahara H, Osako Y, Idichi T, Arai T, Koshizuka K, Kita Y, Maemura K, Natsugoe S., Free PMC Article | 03/11/2017 |
| Study of the role of the C-terminal residues in the structure of unbound TIS11d, the E220A mutant and the truncation mutant lacking the last two residues (D219/E220) using molecular dynamics, NMR spectroscopy, and biochemical methods | Probing the structural and dynamical effects of the charged residues of the TZF domain of TIS11d.
Morgan BR, Deveau LM, Massi F., Free PMC Article | 05/7/2016 |
| The roles of TTP and BRF proteins in regulated mRNA decay. | The roles of TTP and BRF proteins in regulated mRNA decay.
Sanduja S, Blanco FF, Dixon DA., Free PMC Article | 03/24/2012 |
| Data suggest that the dysregulation of TIS11D function is associated with the pathogenesis of certain types of leukemia. | Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia.
Iwanaga E, Nanri T, Mitsuya H, Asou N., Free PMC Article | 05/28/2011 |
| ZFP36L2 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. | Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
Igci YZ, Arslan A, Akarsu E, Erkilic S, Igci M, Oztuzcu S, Cengiz B, Gogebakan B, Cakmak EA, Demiryurek AT. | 04/26/2011 |
| Multiple nanosecond timescale molecular dynamics trajectories of TIS11d wild-type and E157R/E195K mutant with different RNA sequences were performed to investigate the molecular basis for RNA binding specificities of this TZF domain. | A computational study of RNA binding and specificity in the tandem zinc finger domain of TIS11d.
Morgan BR, Massi F., Free PMC Article | 09/6/2010 |
| Sequence specificity in RNA recognition is achieved by a network of intermolecular hydrogen bonds, mostly between TIS11d main-chain functional groups and the Watson-Crick edges of the bases | Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d.
Hudson BP, Martinez-Yamout MA, Dyson HJ, Wright PE. | 01/21/2010 |
| polymorphisms sequenced in genomic DNA encoding the TTP protein (ZFP36) and those of its two known mammalian relatives, ZFP36L1 and ZFP36L2, from 72 to 92 anonymous human subjects from various geographical and ethnic backgrounds | Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins.
Blackshear PJ, Phillips RS, Vazquez-Matias J, Mohrenweiser H. | 01/21/2010 |
| These data suggest TIS11D as a candidate p53 target gene that may be part of the network of genes responsible for p53-dependent apoptosis. | TIS11D is a candidate pro-apoptotic p53 target gene.
Jackson RS 2nd, Cho YJ, Liang P. | 01/21/2010 |