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    STAT4 signal transducer and activator of transcription 4 [ Homo sapiens (human) ]

    Gene ID: 6775, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Signal Transducer and Activator of Transcription 4-Induced Up-Regulated LINC01278 Enhances Proliferation and Invasion of Non-Small Cell Lung Cancer Cells via the MicroRNA-877-5p/Activating Transcription Factor 4 Axis.

    Signal Transducer and Activator of Transcription 4-Induced Up-Regulated LINC01278 Enhances Proliferation and Invasion of Non-Small Cell Lung Cancer Cells via the MicroRNA-877-5p/Activating Transcription Factor 4 Axis.
    Yang L, Xiao Y, Deng S, Yan D, Li Z, Wang Y, Lei C.,

    10/8/2024
    Investigating the Link between STAT4 Genetic Variants, STAT4 Protein Concentrations, and Laryngeal Squamous Cell Carcinoma: A Comprehensive Analysis of Clinical Manifestations.

    Investigating the Link between STAT4 Genetic Variants, STAT4 Protein Concentrations, and Laryngeal Squamous Cell Carcinoma: A Comprehensive Analysis of Clinical Manifestations.
    Pileckaite E, Vilkeviciute A, Kriauciuniene L, Liutkevicius V, Liutkeviciene R., Free PMC Article

    10/7/2024
    Association between STAT4 gene polymorphism and susceptibility to pulmonary tuberculosis in the Moldavian population.

    Association between STAT4 gene polymorphism and susceptibility to pulmonary tuberculosis in the Moldavian population.
    Varzari A, Tudor E, Corloteanu A, Axentii E, Vladei I, Deyneko IV.

    08/2/2024
    Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population.

    Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population.
    Cui J, Tong R, Xu J, Tian Y, Pan J, Wang N, Chen H, Peng Y, Fei S, Ling W, Guo C, Yao J, Cui W., Free PMC Article

    07/25/2024
    The Role of JAK-STAT-SOCS1 Axis in Tumorigenesis, Malignant Progression and Lymphatic Metastasis of Penile Cancer.

    The Role of JAK-STAT-SOCS1 Axis in Tumorigenesis, Malignant Progression and Lymphatic Metastasis of Penile Cancer.
    Xu DM, Chen LX, Zhuang XY, Han H, Mo M., Free PMC Article

    06/7/2024
    STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway.

    STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway.
    Zhang X, Wang Y, Lv J.

    04/11/2024
    Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.

    Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
    Cheng B, Li L, Luo T, Wang Q, Luo Y, Bai S, Li K, Lai Y, Huang H., Free PMC Article

    03/14/2024
    STAT4 Gene Variant rs7574865 Is Associated with Rheumatoid Arthritis Activity and Anti-CCP Levels in the Western but Not in the Southern Population of Mexico.

    STAT4 Gene Variant rs7574865 Is Associated with Rheumatoid Arthritis Activity and Anti-CCP Levels in the Western but Not in the Southern Population of Mexico.
    Bravo-Villagra KM, Muñoz-Valle JF, Baños-Hernández CJ, Cerpa-Cruz S, Navarro-Zarza JE, Parra-Rojas I, Aguilar-Velázquez JA, García-Arellano S, López-Quintero A., Free PMC Article

    02/28/2024
    TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides.

    TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides.
    Örnek S, Ozekinci S, Ipin T, Kocaturk E.

    02/7/2024
    Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation.

    Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation.
    Scarno G, Mazej J, Laffranchi M, Di Censo C, Mattiola I, Candelotti AM, Pietropaolo G, Stabile H, Fionda C, Peruzzi G, Brooks SR, Tsai WL, Mikami Y, Bernardini G, Gismondi A, Sozzani S, Di Santo JP, Vosshenrich CAJ, Diefenbach A, Gadina M, Santoni A, Sciumè G., Free PMC Article

    09/29/2023
    STAT4, a potential predictor of prognosis, promotes CD8 T-cell infiltration in ovarian serous carcinoma by inducing CCL5 secretion.

    STAT4, a potential predictor of prognosis, promotes CD8 T‑cell infiltration in ovarian serous carcinoma by inducing CCL5 secretion.
    Wang W, Liu S, Lu F, Yang B, Zhuang X, Yin J, Chen G, Sun C., Free PMC Article

    06/7/2023
    Down-Regulation-Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-gamma Production.

    Down-Regulation-Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-γ Production.
    Madera-Salcedo IK, Ramírez-Sánchez AL, Rodríguez-Rodríguez N, García-Quintero R, Rubio RM, Morales-Montes de Oca G, Dávalos E, Cuervo R, Furuzawa-Carballeda J, Alcocer-Varela J, Gómez-Martín D, González-Yáñez M, de la Cruz A, Albarrán-Godínez A, Suárez-Rojas G, Romero-Díaz J, Uribe-Uribe NO, Alarcón-Riquelme M, Furlan-Magaril M, Mejía-Vilet JM, Crispín JC, Rosetti F.

    06/1/2023
    Defective binding of ETS1 and STAT4 due to a mutation in the promoter region of THPO as a novel mechanism of congenital amegakaryocytic thrombocytopenia.

    Defective binding of ETS1 and STAT4 due to a mutation in the promoter region of THPO as a novel mechanism of congenital amegakaryocytic thrombocytopenia.
    Capaci V, Adam E, Bar-Joseph I, Faleschini M, Pecci A, Savoia A., Free PMC Article

    05/5/2023
    Association of the STAT4 Gene rs7574865 Polymorphism with IFN-gamma Levels in Patients with Systemic Lupus Erythematosus.

    Association of the STAT4 Gene rs7574865 Polymorphism with IFN-γ Levels in Patients with Systemic Lupus Erythematosus.
    Esparza Guerrero Y, Vazquez Villegas ML, Nava Valdivia CA, Ponce Guarneros JM, Perez Guerrero EE, Gomez Ramirez EE, Ramirez Villafaña M, Contreras Haro B, Martinez Hernandez A, Cardona Muñoz EG, Nuño Arana I, Gallardo Moya SG, Celis A, Gonzalez Lopez L, Gamez Nava JI, Saldaña Cruz AM., Free PMC Article

    04/14/2023
    The effects of the interactions of STAT4 rs7574865 with HBV mutations on the risk of hepatocellular carcinoma.

    The effects of the interactions of STAT4 rs7574865 with HBV mutations on the risk of hepatocellular carcinoma.
    Yang C, Chen H, Zhou B, Yin J, Cao G, Hou J, Jiang D.

    09/24/2022
    T Cells With Activated STAT4 Drive the High-Risk Rejection State to Renal Allograft Failure After Kidney Transplantation.

    T Cells With Activated STAT4 Drive the High-Risk Rejection State to Renal Allograft Failure After Kidney Transplantation.
    Chen Y, Zhang B, Liu T, Chen X, Wang Y, Zhang H., Free PMC Article

    07/30/2022
    STAT4 genetic polymorphism significantly affected HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients receiving Peginterferon-alpha therapy: A prospective cohort study in China.

    STAT4 genetic polymorphism significantly affected HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients receiving Peginterferon-α therapy: A prospective cohort study in China.
    Qi X, Li F, Zhang Y, Zhu H, Yang F, Li X, Jiang X, Chen L, Huang Y, Zhang J.

    07/23/2022
    STAT4 and COL1A2 are potential diagnostic biomarkers and therapeutic targets for heart failure comorbided with depression.

    STAT4 and COL1A2 are potential diagnostic biomarkers and therapeutic targets for heart failure comorbided with depression.
    Huang K, Zhang X, Duan J, Wang R, Wu Z, Yang C, Yang L.

    05/7/2022
    Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.

    Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.
    Yang F, Liu XQ, He JZ, Xian SP, Yang PF, Mai ZY, Li M, Liu Y, Zhang XD., Free PMC Article

    04/16/2022
    Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway.

    Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway.
    Wang C, Gao N, Yang L, Guo Y, Fang Y, Wang T, Xu C, Li GF, Zhou J, Zhang Y, Wen Q, Qiao H., Free PMC Article

    04/16/2022
    Regional heritability mapping identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population.

    Regional heritability mapping identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population.
    Gervais O, Ueno K, Kawai Y, Hitomi Y, Aiba Y, Ueta M, Nakamura M, Tokunaga K, Nagasaki M., Free PMC Article

    03/19/2022
    A new discovery of STAT4 single nucleotide polymorphisms associated with hepatocellular carcinoma risk in Chinese Han population: a case-control study.

    A new discovery of STAT4 single nucleotide polymorphisms associated with hepatocellular carcinoma risk in Chinese Han population: a case-control study.
    Chao X, Wu J, Zhang W, Feng X, Zhao L, Huang F, Jiang C., Free PMC Article

    02/5/2022
    Genetic variants in STAT4 and their interactions with environmental factors for the incidence of hepatocellular carcinoma.

    Genetic variants in STAT4 and their interactions with environmental factors for the incidence of hepatocellular carcinoma.
    Zhong X, Luo M, Wu Y, Zhou X, Yu X, Liu L, Chen S.

    02/5/2022
    Association of the STAT4, CDKN1A, and IRF5 variants with risk of lupus nephritis and renal biopsy classification in patients in Vietnam.

    Association of the STAT4, CDKN1A, and IRF5 variants with risk of lupus nephritis and renal biopsy classification in patients in Vietnam.
    Nghiem TD, Do GT, Luong LH, Nguyen QL, Dang HV, Viet AN, Nguyen TT, Tran VK, Ta TV, Tran TH., Free PMC Article

    12/11/2021
    Association of STAT4 Gene Rs7574865, Rs10168266 Polymorphisms and Systemic Lupus Erythematosus Susceptibility: A Meta-analysis.

    Association of STAT4 Gene Rs7574865, Rs10168266 Polymorphisms and Systemic Lupus Erythematosus Susceptibility: A Meta-analysis.
    Wang JM, Xu WD, Huang AF.

    10/2/2021
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