| Acetylation of Steroidogenic Acute Regulatory Protein Sensitizes 17beta-Estradiol Regulation in Hormone-Sensitive Breast Cancer Cells. | Acetylation of Steroidogenic Acute Regulatory Protein Sensitizes 17β-Estradiol Regulation in Hormone-Sensitive Breast Cancer Cells.
Manna PR, Molehin D, Ahmed AU, Yang S, Reddy PH., Free PMC Article | 08/31/2024 |
| Clinical spectrum of human STAR variants and their genotype-phenotype correlation. | Clinical spectrum of human STAR variants and their genotype-phenotype correlation.
Altinkilic EM, Augsburger P, Pandey AV, Flück CE. | 08/16/2024 |
| Differential regulation of STARD1, STARD4 and STARD6 in the human ovary. | Differential regulation of STARD1, STARD4 and STARD6 in the human ovary.
Yahya NA, King SR, Shi B, Shaaban A, Whitfield NE, Yan C, Kordus RJ, Whitman-Elia GF, LaVoie HA., | 07/29/2024 |
| Steroidogenic acute regulatory protein (STAR) deficiency: Our experience and systematic review for phenotype-genotype correlation. | Steroidogenic acute regulatory protein (STAR) deficiency: Our experience and systematic review for phenotype-genotype correlation.
Phadte A, Dhole C, Hegishte S, Sarathi V, Lila A, Gada JV, Memon SS, Arya S, Karlekar M, Patil V, Varthakavi PK, Shah N, Bhagwat NM, Bandgar T. | 04/16/2024 |
| Bone morphogenetic protein-9 downregulates StAR expression by inducing snail expression via SMAD1/5/8 signaling in human granulosa-lutein cells. | Bone morphogenetic protein-9 downregulates StAR expression by inducing snail expression via SMAD1/5/8 signaling in human granulosa-lutein cells.
Liu B, Fu B, Zhou S, Wang H, Bi B, Guo M, Cheng JC, Fang L. | 02/9/2024 |
| Impose of KNDy/GnRH neural circuit in PCOS, ageing, cancer and Alzheimer's disease: StAR actions in prevention of neuroendocrine dysfunction. | Impose of KNDy/GnRH neural circuit in PCOS, ageing, cancer and Alzheimer's disease: StAR actions in prevention of neuroendocrine dysfunction.
Panda SP, Kesharwani A, Singh GD, Prasanth D, Vatchavai BR, Kumari PVK, Panda SK, Mallick SP. | 12/21/2023 |
| Downregulation of StAR driven neurosteroid biosynthesis as a distinctive feature in the brains of Alzheimer's disease patients. | Downregulation of StAR driven neurosteroid biosynthesis as a distinctive feature in the brains of Alzheimer's disease patients.
Manna PR, Bose C, Reddy PH. | 06/7/2023 |
| New molecular insights into the A218V variant impact on the steroidogenic acute regulatory protein (STAR) associated with 46, XY disorders of sexual development. | New molecular insights into the A218V variant impact on the steroidogenic acute regulatory protein (STAR) associated with 46, XY disorders of sexual development.
Aghaei S, Farrokhi E, Saffari-Chaleshtori J, Hoseinzadeh M, Molavi N, Hashemipour M, Rostampour N, Asgharzadeh S, Tabatabaiefar MA. | 05/1/2023 |
| Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer. | Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer.
Manna PR, Ramachandran S, Pradeepkiran JA, Molehin D, Castro-Piedras I, Pruitt K, Ganapathy V, Reddy PH., Free PMC Article | 01/28/2023 |
| Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells. | Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells.
Jia Q, Liu B, Dang X, Guo Y, Han X, Song T, Cheng JC, Fang L., Free PMC Article | 03/26/2022 |
| STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. | STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway.
Conde de la Rosa L, Garcia-Ruiz C, Vallejo C, Baulies A, Nuñez S, Monte MJ, Marin JJG, Baila-Rueda L, Cenarro A, Civeira F, Fuster J, Garcia-Valdecasas JC, Ferrer J, Karin M, Ribas V, Fernandez-Checa JC., Free PMC Article | 01/29/2022 |
| Distinctive functioning of STARD1 in the fetal Leydig cells compared to adult Leydig and adrenal cells. Impact of Hedgehog signaling via the primary cilium. | Distinctive functioning of STARD1 in the fetal Leydig cells compared to adult Leydig and adrenal cells. Impact of Hedgehog signaling via the primary cilium.
Kothandapani A, Larsen MC, Lee J, Jorgensen JS, Jefcoate CR. | 12/11/2021 |
| Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. | Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family.
Tugaeva KV, Titterington J, Sotnikov DV, Maksimov EG, Antson AA, Sluchanko NN. | 05/22/2021 |
| Clinical and molecular characterization of thirty Chinese patients with congenital lipoid adrenal hyperplasia. | Clinical and molecular characterization of thirty Chinese patients with congenital lipoid adrenal hyperplasia.
Zhang T, Ma X, Wang J, Jia C, Wang W, Dong Z, Ye L, Sun S, Hu R, Ning G, Li C, Lu W. | 05/8/2021 |
| Characterization of Two Novel Variants of the Steroidogenic Acute Regulatory Protein Identified in a Girl with Classic Lipoid Congenital Adrenal Hyperplasia. | Characterization of Two Novel Variants of the Steroidogenic Acute Regulatory Protein Identified in a Girl with Classic Lipoid Congenital Adrenal Hyperplasia.
Katharopoulos E, Di Iorgi N, Fernandez-Alvarez P, Pandey AV, Groessl M, Dubey S, Camats N, Napoli F, Patti G, Lezzi M, Maghnie M, Flück CE., Free PMC Article | 02/27/2021 |
| Lipoid congenital adrenal hyperplasia due to steroid acute regulatory protein (STAR) variants in Three Chinese patients. | Lipoid congenital adrenal hyperplasia due to steroid acute regulatory protein (STAR) variants in Three Chinese patients.
Chen H, Zhang Q, Chen R, Yuan X, Lin X, Yang X, Zhang Y. | 11/21/2020 |
| noncoding-RNA-mediated regulation of STAR may play an important role in the regulation of steroid hormone production. | Absence of the long noncoding RNA H19 results in aberrant ovarian STAR and progesterone production.
Chen Y, Wang J, Fan Y, Qin C, Xia X, Johnson J, Kallen AN., Free PMC Article | 01/18/2020 |
| The StAR protein is abundantly expressed in breast cancer but not in normal mammary epithelial cells. StAR is identified as a novel acetylated protein. | Overexpression of the steroidogenic acute regulatory protein in breast cancer: Regulation by histone deacetylase inhibition.
Manna PR, Ahmed AU, Vartak D, Molehin D, Pruitt K., Free PMC Article | 11/2/2019 |
| Studies of mice with liver-specific deletion of Stard1 and mice with humanized livers found that upregulation of STARD1 following endoplasmic reticulum stress mediates acetaminophen hepatoxicity via SH3BP5 and phosphorylation of JNK1 and JNK2. | Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure.
Torres S, Baulies A, Insausti-Urkia N, Alarcón-Vila C, Fucho R, Solsona-Vilarrasa E, Núñez S, Robles D, Ribas V, Wakefield L, Grompe M, Lucena MI, Andrade RJ, Win S, Aung TA, Kaplowitz N, García-Ruiz C, Fernández-Checa JC. | 08/31/2019 |
| We further explored the dissociation of mRNA from STAR domain using umbrella sampling simulations, and the results suggest that mRNA binding to STAR domain occurs in multi-step: first conformational selection of mRNA backbone conformations, followed by induced fit mechanism as nucleobases interact with STAR domain | Mechanism of mRNA-STAR domain interaction: Molecular dynamics simulations of Mammalian Quaking STAR protein.
Sharma M, Anirudh CR., Free PMC Article | 06/29/2019 |
| This study aimed to investigate the phenotypic and mutation spectrum of STAR defects and identify a founder effect of the p.Q258* mutation in Korean patients with congenital lipoid adrenal hyperplasia. | Mutation Spectrum of STAR and a Founder Effect of the p.Q258* in Korean Patients with Congenital Lipoid Adrenal Hyperplasia.
Kang E, Kim YM, Kim GH, Lee BH, Yoo HW, Choi JH., Free PMC Article | 01/5/2019 |
| The present study revealed that StAR overexpression can reduce hepatic lipid accumulation, regulate glucose metabolism and attenuate insulin resistance through a mechanism involving the activation of FXR. | Steroidogenic acute regulatory protein (StAR) overexpression attenuates HFD-induced hepatic steatosis and insulin resistance.
Qiu Y, Sui X, Zhan Y, Xu C, Li X, Ning Y, Zhi X, Yin L. | 11/24/2018 |
| Reduced fractalkine levels were found in follicular fluid and granulosa cells, accompanied by decreased progesterone production and reduced steroidogenic acute regulatory protein (StAR) expression in the granulosa cells of patients with polycystic ovary syndrome. Administration of fractalkine reversed the inhibition of progesterone and StAR expression. | Fractalkine restores the decreased expression of StAR and progesterone in granulosa cells from patients with polycystic ovary syndrome.
Huang S, Pang Y, Yan J, Lin S, Zhao Y, Lei L, Yan L, Li R, Ma C, Qiao J., Free PMC Article | 03/31/2018 |
| Remarkably, in terms of fluorescence response, 20NP slightly outperforms commonly used 22NC and can thus be used for screening of various potential ligands by a competition mechanism in the future. | Effect of the NBD-group position on interaction of fluorescently-labeled cholesterol analogues with human steroidogenic acute regulatory protein STARD1.
Tugaeva KV, Faletrov YV, Allakhverdiev ES, Shkumatov VM, Maksimov EG, Sluchanko NN. | 03/24/2018 |
| solution structure of human steroidogenic acute regulatory protein STARD1 studied by small-angle X-ray scattering | Solution structure of human steroidogenic acute regulatory protein STARD1 studied by small-angle X-ray scattering.
Sluchanko NN, Tugaeva KV, Maksimov EG. | 09/23/2017 |