| Stage-specific regulation of undifferentiated spermatogonia by AKT1S1-mediated AKT-mTORC1 signaling during mouse spermatogenesis. | Stage-specific regulation of undifferentiated spermatogonia by AKT1S1-mediated AKT-mTORC1 signaling during mouse spermatogenesis.
Yang L, Liao J, Huang H, Lee TL, Qi H. | 03/13/2024 |
| This study, for the first time, links PF4's anti-RNV function to an intracellular signaling molecule PRAS40 and its phosphorylation. | PF4 antagonizes retinal neovascularization via inhibiting PRAS40 phosphorylation in a mouse model of oxygen-induced retinopathy.
Cai S, Yang Q, Cao Y, Li Y, Liu J, Wang J, Zhang X, Liu L, Li X, Zhang Y. | 08/13/2020 |
| Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development | Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development.
Rho O, Srivastava J, Cho J, DiGiovanni J., Free PMC Article | 06/24/2017 |
| PRAS40 inhibits mTORC1 hyperactivation and plays a key role in protecting cells against neurotoxic prion peptide-induced apoptosis. Thus, PRAS40 is a potential therapeutic target for prion disease. | PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling.
Yang W, Yang LF, Song ZQ, Shah SZA, Cui YY, Li CS, Zhao HF, Gao HL, Zhou XM, Zhao DM., Free PMC Article | 05/20/2017 |
| PRAS40 appears to reduce brain injury following ischemic stroke by converting cell signaling from Akt to mTOR | PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways.
Xiong X, Xie R, Zhang H, Gu L, Xie W, Cheng M, Jian Z, Kovacina K, Zhao H., Free PMC Article | 09/27/2014 |
| PRAS40 treatment improves hepatic insulin sensitivity and reduces systemic hyperglycaemia in obese mice. | PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.
Völkers M, Doroudgar S, Nguyen N, Konstandin MH, Quijada P, Din S, Ornelas L, Thuerauf DJ, Gude N, Friedrich K, Herzig S, Glembotski CC, Sussman MA., Free PMC Article | 07/26/2014 |
| PRAS40 phosphorylation acts as a molecular switch allowing mTORC1 activation during physiological growth, opening up unique possibilities for therapeutic regulation of the mTORC1 complex to mitigate pathologic myocardial hypertrophy by PRAS40 | Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.
Völkers M, Toko H, Doroudgar S, Din S, Quijada P, Joyo AY, Ornelas L, Joyo E, Thuerauf DJ, Konstandin MH, Gude N, Glembotski CC, Sussman MA., Free PMC Article | 11/30/2013 |
| Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism. | Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.
Caccamo A, Maldonado MA, Majumder S, Medina DX, Holbein W, Magrí A, Oddo S., Free PMC Article | 05/21/2011 |
| These results suggest that a reduction in PRAS40 specifically impairs myoblast protein synthesis, cell cycle, proliferation and differentiation to myotubes. | PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts.
Kazi AA, Lang CH., Free PMC Article | 01/1/2011 |
| after mTORC1 kinase activation by upstream regulators, PRAS40 is phosphorylated directly by mTOR, thus contributing to the relief of PRAS40-mediated substrate competition. | Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.
Wang L, Harris TE, Lawrence JC Jr., Free PMC Article | 01/21/2010 |
| PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. | PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.
Wang L, Harris TE, Roth RA, Lawrence JC Jr. | 01/21/2010 |
| PRAS40 is an important regulator of insulin sensitivity of the Akt-mTOR pathway and a potential target for the treatment of cancers, insulin resistance and hamartoma syndromes. | Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH. | 01/21/2010 |
| PRAS phosphorylation and its interaction with pAkt and 14-3-3 might play an important role in neuroprotection mediated by NGF in apoptotic neuronal cell death after transient focal cerebral ischemia | Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH., Free PMC Article | 01/21/2010 |
| overexpression of SOD1 may affect the PRAS pathway after transient focal cerebral ischemia by reducing the direct oxidative reaction to pPRAS after reperfusion injury | Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia.
Saito A, Hayashi T, Okuno S, Nishi T, Chan PH. | 01/21/2010 |
| The protein product encoded by 1110012J22 gene is proline-rich substrate of Akt which also binds to 14-3-3. A proposed name for this protein is thus PRAS40, for proline-rich substrate of Akt of 40 kDa. | Identification of a proline-rich Akt substrate as a 14-3-3 binding partner.
Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA. | 01/30/2003 |