| Neurotensin accelerates atherosclerosis and increases circulating levels of short-chain and saturated triglycerides. | Neurotensin accelerates atherosclerosis and increases circulating levels of short-chain and saturated triglycerides.
Li J, Yang L, Song J, Yan B, Morris AJ, Moseley H, Flight R, Wang C, Liu J, Weiss HL, Morris EF, Abdelhamid I, Gerl MJ, Melander O, Smyth S, Evers BM., | 07/9/2024 |
| Neurotensin counteracts hair growth inhibition induced by chronic restraint stress. | Neurotensin counteracts hair growth inhibition induced by chronic restraint stress.
Chen L, Yu Q, Guo F, Wang X, Cai Z, Zhou Q. | 02/5/2024 |
| Regulation of Atherosclerosis Development by Neurotensin Derived From Lymphatic Endothelial Cells in Mice. | Regulation of Atherosclerosis Development by Neurotensin Derived From Lymphatic Endothelial Cells in Mice.
Liu C, Xiong X, Li J., Free PMC Article | 08/25/2023 |
| Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin. | Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin.
Liu C, Yi C, Fu W, Xiong X, Li J. | 06/22/2023 |
| Neurotensin expression, regulation, and function during the ovulatory period in the mouse ovarydagger. | Neurotensin expression, regulation, and function during the ovulatory period in the mouse ovary†.
Shrestha K, Al-Alem L, Garcia P, Wynn MAA, Hannon PR, Jo M, Drnevich J, Duffy DM, Curry TE Jr., Free PMC Article | 02/22/2023 |
| Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling. | Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling.
Tschumi CW, Blankenship HE, Sharma R, Lynch WB, Beckstead MJ., Free PMC Article | 08/20/2022 |
| Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells. | Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.
Li J, Li E, Czepielewski RS, Chi J, Guo X, Han YH, Wang D, Wang L, Hu B, Dawes B, Jacobs C, Tenen D, Lin SJ, Lee B, Morris D, Tobias A, Randolph GJ, Cohen P, Tsai L, Rosen ED., Free PMC Article | 04/2/2022 |
| Neurotensin Attenuates Nociception by Facilitating Inhibitory Synaptic Transmission in the Mouse Spinal Cord. | Neurotensin Attenuates Nociception by Facilitating Inhibitory Synaptic Transmission in the Mouse Spinal Cord.
Zhang MM, Feng YP, Qiu XT, Chen T, Bai Y, Feng JM, Wang JD, Chen Y, Zhang MZ, Duan HK, Zhao M, Teng YH, Cao J, Zang WD, Yang K, Li YQ., Free PMC Article | 02/5/2022 |
| Effect of neurotensin on cultured mouse preimplantation embryos. | Effect of neurotensin on cultured mouse preimplantation embryos.
Hiradate Y, Hara K, Tanemura K., Free PMC Article | 08/28/2021 |
| Study found that locally-released neurotensin (NT) and dynorphin (Dyn) antagonistically regulated central amygdala (CeA) inhibitory inputs onto oval bed nucleus of the stria terminalis (ovBNST) neurons. NT and Dyn respectively increased and decreased CeA-toovBNST inhibitory inputs through NT receptor 1 and kappa opioid receptor. NT and Dyn mRNAs were highly co-localized in ovBNST neurons. | Neurotensin and dynorphin Bi-Directionally modulate CeA inhibition of oval BNST neurons in male mice.
Normandeau CP, Torruella Suárez ML, Sarret P, McElligott ZA, Dumont EC., Free PMC Article | 03/2/2019 |
| Study reveals multiple populations of neurotensin neurons that provide direct afferents to the ventral tegmental area and which may regulate specific aspects of motivated behavior. | Determination of neurotensin projections to the ventral tegmental area in mice.
Woodworth HL, Brown JA, Batchelor HM, Bugescu R, Leinninger GM., Free PMC Article | 09/8/2018 |
| The weight loss behaviors are mediated by distinct signaling pathways: Nts action via NtsR1 is essential for the anorectic effect of the lateral hypothalamic Nts circuit, but not for regulation of locomotor or drinking behavior. | Lateral Hypothalamic Neurotensin Neurons Orchestrate Dual Weight Loss Behaviors via Distinct Mechanisms.
Woodworth HL, Beekly BG, Batchelor HM, Bugescu R, Perez-Bonilla P, Schroeder LE, Leinninger GM., Free PMC Article | 07/28/2018 |
| Nts-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors. | Loss of Action via Neurotensin-Leptin Receptor Neurons Disrupts Leptin and Ghrelin-Mediated Control of Energy Balance.
Brown JA, Bugescu R, Mayer TA, Gata-Garcia A, Kurt G, Woodworth HL, Leinninger GM., Free PMC Article | 10/14/2017 |
| findings directly link NT with increased fat absorption and obesity and suggest that NT may provide a prognostic marker of future obesity and a potential target for prevention and treatment | An obligatory role for neurotensin in high-fat-diet-induced obesity.
Li J, Song J, Zaytseva YY, Liu Y, Rychahou P, Jiang K, Starr ME, Kim JT, Harris JW, Yiannikouris FB, Katz WS, Nilsson PM, Orho-Melander M, Chen J, Zhu H, Fahrenholz T, Higashi RM, Gao T, Morris AJ, Cassis LA, Fan TW, Weiss HL, Dobner PR, Melander O, Jia J, Evers BM., Free PMC Article | 06/28/2016 |
| Data (including data from studies in transgenic mice) suggest Nts, glucagon-like peptide I, and peptide YY are closely co-expressed/co-secreted within enteroendocrine cells in ileum mucosa; however, Nts is stored in distinct/separate secretory granules. | Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism.
Grunddal KV, Ratner CF, Svendsen B, Sommer F, Engelstoft MS, Madsen AN, Pedersen J, Nøhr MK, Egerod KL, Nawrocki AR, Kowalski T, Howard AD, Poulsen SS, Offermanns S, Bäckhed F, Holst JJ, Holst B, Schwartz TW. | 05/21/2016 |
| The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported. | Neurotensin enhances sperm capacitation and acrosome reaction in mice.
Hiradate Y, Inoue H, Kobayashi N, Shirakata Y, Suzuki Y, Gotoh A, Roh SG, Uchida T, Katoh K, Yoshida M, Sato E, Tanemura K. | 05/14/2016 |
| endogenous changes occur in NT and its receptors across multiple brain regions, and these likely support the emergence of some maternal behaviors. | Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice.
Driessen TM, Zhao C, Whittlinger A, Williams H, Gammie SC., Free PMC Article | 09/13/2014 |
| These observations suggest the importance of neurotensin in maintaining activity of orexin neurons. | Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states.
Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, Shioda S, Sakurai T., Free PMC Article | 11/16/2013 |
| a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK, secretin, GIP, GLP-1, PYY, and neurotensin | A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.
Egerod KL, Engelstoft MS, Grunddal KV, Nøhr MK, Secher A, Sakata I, Pedersen J, Windeløv JA, Füchtbauer EM, Olsen J, Sundler F, Christensen JP, Wierup N, Olsen JV, Holst JJ, Zigman JM, Poulsen SS, Schwartz TW., Free PMC Article | 02/2/2013 |
| Neurotensin knock-out mice do not differ from their wild-type or heterozygous littermates in either baseline or acute cocaine-stimulated locomotor activity. | Effects of neurotensin gene knockout in mice on the behavioral effects of cocaine.
Hall FS, Centeno M, Perona MT, Adair J, Dobner PR, Uhl GR. | 09/22/2012 |
| Neurotensin increases EGF expression in skin dendritic cells. | Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression.
da Silva L, Neves BM, Moura L, Cruz MT, Carvalho E. | 11/12/2011 |
| NT acutely regulates D2 autoreceptor function and DA neuron excitability through PKC-mediated phosphorylation of the D2R, leading to heterologous receptor desensitization. | Neurotensin triggers dopamine D2 receptor desensitization through a protein kinase C and beta-arrestin1-dependent mechanism.
Thibault D, Albert PR, Pineyro G, Trudeau LÉ., Free PMC Article | 05/21/2011 |
| although neurotensin neurons in the anteroventral periventricular nucleus are targets for regulation by E(2), neurotensin does not appear to play a direct role in generating the GnRH/LH surge in the mouse | Interactions between neurotensin and GnRH neurons in the positive feedback control of GnRH/LH secretion in the mouse.
Dungan Lemko HM, Naderi R, Adjan V, Jennes LH, Navarro VM, Clifton DK, Steiner RA., Free PMC Article | 09/13/2010 |
| NT-mediated IL-6 expression is nuclear factor-kappaB and PKCdelta dependent | Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis.
Koon HW, Kim YS, Xu H, Kumar A, Zhao D, Karagiannides I, Dobner PR, Pothoulakis C., Free PMC Article | 01/21/2010 |
| These results clearly indicate for the first time that NT is able to protect endocrine beta cells from external cytotoxic agents, a role well correlated with its release in the circulation after a meal. | Neurotensin protects pancreatic beta cells from apoptosis.
Coppola T, Béraud-Dufour S, Antoine A, Vincent JP, Mazella J. | 01/21/2010 |