| Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death. | Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death.
Xiong Y, Luo J, Hong ZY, Zhu WZ, Hu A, Song BL., Free PMC Article | 08/14/2024 |
| Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis. | Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis.
Li J, Sun J, Xu M, Yang L, Yang N, Deng J, Ma Y, Qi Y, Liu Z, Ruan Q, Liu Y, Huang Y., Free PMC Article | 08/1/2024 |
| A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression. | A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression.
Plebanek MP, Xue Y, Nguyen YV, DeVito NC, Wang X, Holtzhausen A, Beasley GM, Theivanthiran B, Hanks BA. | 06/17/2024 |
| ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2. | ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2.
Benatzy Y, Palmer MA, Lütjohann D, Ohno RI, Kampschulte N, Schebb NH, Fuhrmann DC, Snodgrass RG, Brüne B., Free PMC Article | 05/28/2024 |
| A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. | A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes.
Yang S, Liu C, Jiang M, Liu X, Geng L, Zhang Y, Sun S, Wang K, Yin J, Ma S, Wang S, Belmonte JCI, Zhang W, Qu J, Liu GH., Free PMC Article | 02/2/2024 |
| Enhanced SREBP2-driven cholesterol biosynthesis by PKClambda/iota deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. | Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Muta Y, Linares JF, Martinez-Ordoñez A, Duran A, Cid-Diaz T, Kinoshita H, Zhang X, Han Q, Nakanishi Y, Nakanishi N, Cordes T, Arora GK, Ruiz-Martinez M, Reina-Campos M, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, García-Solano J, Conesa-Zamora P, Inghirami G, Metallo CM, Osborne TF, Diaz-Meco MT, Moscat J., Free PMC Article | 12/20/2023 |
| Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake. | Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake.
Gu D, Zhou F, You H, Gao J, Kang T, Dixit D, Wu Q, Yang K, Ci S, Shan D, Fan X, Yuan W, Zhang Q, Lu C, Li D, Zhao N, Shi Z, Gao W, Lin F, Man J, Wang Q, Qian X, Mack SC, Tao W, Agnihotri S, Zhang N, You Y, Rich JN, Zhang J, Wang X., Free PMC Article | 09/7/2023 |
| Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells. | Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells.
Bao W, You Y, Ni J, Hou H, Lyu J, Feng G, Wang Y, You K, Zhang S, Zhang L, Cao X, Wang X, Li H, Li H, Xu J, Liu C, Luo X, Du P, Chen D, Shen X., Free PMC Article | 09/6/2023 |
| LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition. | LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition.
Zhang F, Gao J, Liu X, Sun Y, Liu L, Hu B, Wang Z, Shi J, Guo W, Zhang S. | 06/15/2023 |
| Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease. | Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease.
Tang W, Thundyil J, Lim GGY, Tng TJW, Yeow SQZ, Nair A, Chai C, Yao TP, Lim KL., Free PMC Article | 04/27/2023 |
| SREBF2-STARD4 axis confers sorafenib resistance in hepatocellular carcinoma by regulating mitochondrial cholesterol homeostasis. | SREBF2-STARD4 axis confers sorafenib resistance in hepatocellular carcinoma by regulating mitochondrial cholesterol homeostasis.
Yue X, Kong Y, Zhang Y, Sun M, Liu S, Wu Z, Gao L, Liang X, Ma C., Free PMC Article | 02/11/2023 |
| SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration of glioblastoma. | SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration of glioblastoma.
Cheng C, Tu J, Hu Z, Chen Y, Wang Y, Zhang T, Zhang C, Li C, Wang Y, Niu C. | 12/10/2022 |
| Caspase-3-Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma. | Caspase-3-Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma.
Mok EHK, Leung CON, Zhou L, Lei MML, Leung HW, Tong M, Wong TL, Lau EYT, Ng IOL, Ding J, Yun JP, Yu J, Zhu HL, Lin CH, Lindholm D, Leung KS, Cybulski JD, Baker DM, Ma S, Lee TKW. | 09/17/2022 |
| Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells. | Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells.
Fowler JWM, Zhang R, Tao B, Boutagy NE, Sessa WC., Free PMC Article | 08/27/2022 |
| Unspliced XBP1 contributes to cholesterol biosynthesis and tumorigenesis by stabilizing SREBP2 in hepatocellular carcinoma. | Unspliced XBP1 contributes to cholesterol biosynthesis and tumorigenesis by stabilizing SREBP2 in hepatocellular carcinoma.
Wei M, Nurjanah U, Herkilini A, Huang C, Li Y, Miyagishi M, Wu S, Kasim V., Free PMC Article | 08/13/2022 |
| TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2. | TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2.
Egawa N, Izumi Y, Suzuki H, Tsuge I, Fujita K, Shimano H, Izumikawa K, Takahashi N, Tsukita K, Enami T, Nakamura M, Watanabe A, Naitoh M, Suzuki S, Seki T, Kobayashi K, Toda T, Kaji R, Takahashi R, Inoue H., Free PMC Article | 05/28/2022 |
| SREBF2 triggers endoplasmic reticulum stress and Bax dysregulation to promote lipopolysaccharide-induced endothelial cell injury. | SREBF2 triggers endoplasmic reticulum stress and Bax dysregulation to promote lipopolysaccharide-induced endothelial cell injury.
Dong G, Huang X, Wu L, Jiang S, Tan Q, Chen S. | 05/14/2022 |
| LncCCAT1 interaction protein PKM2 upregulates SREBP2 phosphorylation to promote osteosarcoma tumorigenesis by enhancing the Warburg effect and lipogenesis. | LncCCAT1 interaction protein PKM2 upregulates SREBP2 phosphorylation to promote osteosarcoma tumorigenesis by enhancing the Warburg effect and lipogenesis.
Pu F, Liu J, Jing D, Chen F, Huang X, Shi D, Wu W, Lin H, Zhao L, Zhang Z, Lv X, Wang B, Zhang Z, Shao Z., Free PMC Article | 03/26/2022 |
| SREBP2 promotes the viability, proliferation, and migration and inhibits apoptosis in TGF-beta1-induced airway smooth muscle cells by regulating TLR2/NF-kappaB/NFATc1/ABCA1 regulatory network. | SREBP2 promotes the viability, proliferation, and migration and inhibits apoptosis in TGF-β1-induced airway smooth muscle cells by regulating TLR2/NF-κB/NFATc1/ABCA1 regulatory network.
Wang Y, Yang H, Su X, Cao A, Chen F, Chen P, Yan F, Hu H., Free PMC Article | 03/12/2022 |
| DNA Methylation Profile of the SREBF2 Gene in Human Fetal Aortas. | DNA Methylation Profile of the SREBF2 Gene in Human Fetal Aortas.
Schiano C, D'Armiento M, Franzese M, Castaldo R, Saccone G, de Nigris F, Grimaldi V, Soricelli A, D'Armiento FP, Zullo F, Napoli C. | 02/26/2022 |
| Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer. | Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer.
Cai C, Zhang Y, Peng X., Free PMC Article | 02/19/2022 |
| TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination. | TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
Ho WY, Chang JC, Lim K, Cazenave-Gassiot A, Nguyen AT, Foo JC, Muralidharan S, Viera-Ortiz A, Ong SJM, Hor JH, Agrawal I, Hoon S, Arogundade OA, Rodriguez MJ, Lim SM, Kim SH, Ravits J, Ng SY, Wenk MR, Lee EB, Tucker-Kellogg G, Ling SC., Free PMC Article | 11/13/2021 |
| Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. | Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency.
Shin S, Zhou H, He C, Wei Y, Wang Y, Shingu T, Zeng A, Wang S, Zhou X, Li H, Zhang Q, Mo Q, Long J, Lan F, Chen Y, Hu J., Free PMC Article | 06/12/2021 |
| Association of SREBF-2 gene polymorphisms with the risk of developing type 2 diabetes mellitus. | Association of SREBF-2 gene polymorphisms with the risk of developing type 2 diabetes mellitus.
Zhang Y, Sun XX, Liu YC, Wang YD. | 05/8/2021 |
| The miR-28-5p Targetome Discovery Identified SREBF2 as One of the Mediators of the miR-28-5p Tumor Suppressor Activity in Prostate Cancer Cells. | The miR-28-5p Targetome Discovery Identified SREBF2 as One of the Mediators of the miR-28-5p Tumor Suppressor Activity in Prostate Cancer Cells.
Fazio S, Berti G, Russo F, Evangelista M, D'Aurizio R, Mercatanti A, Pellegrini M, Rizzo M., Free PMC Article | 02/13/2021 |