| SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress. | SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress.
Ren J, Che Y, Li H, Gao H, Wang Y, Wang Y, Su H, Li Z, Li J, Qu P., Free PMC Article | 08/28/2024 |
| GRIM-19 deficiency promotes macrophage polarization to the M1 phenotype partly through glycolysis in unexplained recurrent spontaneous abortiondagger. | GRIM-19 deficiency promotes macrophage polarization to the M1 phenotype partly through glycolysis in unexplained recurrent spontaneous abortion†.
Wang B, Yang Y, Ye J, Han X, Yang L, Huang Y, Chao L. | 04/29/2024 |
| GRIM19 deficiency aggravates metabolic disorder and ovarian dysfunction in PCOS. | GRIM19 deficiency aggravates metabolic disorder and ovarian dysfunction in PCOS.
Yang L, Yang Y, Han X, Huang C, Wang Y, Jiang D, Chao L. | 04/16/2024 |
| Grim-19 plays a key role in mitochondrial steroidogenic acute regulatory protein stability and ligand-binding properties in Leydig cells. | Grim-19 plays a key role in mitochondrial steroidogenic acute regulatory protein stability and ligand-binding properties in Leydig cells.
Qu H, He K, Zou ZH, Niu G, Lu L, Yao B, Zhong WW, Wang DJ, Li W., Free PMC Article | 01/14/2023 |
| Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion. | Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion.
Yang Y, Liu H, Zhao Y, Geng C, Chao L, Hao A., Free PMC Article | 11/26/2022 |
| The effect and mechanism of Grim 19 on mouse sperm quality and testosterone synthesis. | The effect and mechanism of Grim 19 on mouse sperm quality and testosterone synthesis.
Zhao Y, Liu H, Yang Y, Huang W, Chao L. | 05/28/2022 |
| GRIM19 is involved in WT1 expression and epithelial-to-mesenchymal transition in adenomyotic lesions. | GRIM19 is involved in WT1 expression and epithelial-to-mesenchymal transition in adenomyotic lesions.
Geng C, Liu HR, Zhao Y, Yang Y, Chao L. | 03/19/2022 |
| GRIM-19 is a target of mycobacterial Zn(2+) metalloprotease 1 and indispensable for NLRP3 inflammasome activation. | GRIM-19 is a target of mycobacterial Zn(2+) metalloprotease 1 and indispensable for NLRP3 inflammasome activation.
Kurane T, Matsunaga T, Ida T, Sawada K, Nishimura A, Fukui M, Umemura M, Nakayama M, Ohara N, Matsumoto S, Akaike T, Matsuzaki G, Takaesu G. | 01/15/2022 |
| GRIM19 Impedes Obesity by Regulating Inflammatory White Fat Browning and Promoting Th17/Treg Balance. | GRIM19 Impedes Obesity by Regulating Inflammatory White Fat Browning and Promoting Th17/Treg Balance.
Jhun J, Woo JS, Lee SH, Jeong JH, Jung K, Hur W, Lee SY, Ryu JY, Moon YM, Jung YJ, Song KY, Chang K, Yoon SK, Park SH, Cho ML., Free PMC Article | 07/10/2021 |
| the present study examined the distribution patterns of GRIM-19 in the adult C57BL/6 mouse brain | Heterogeneity of GRIM-19 Expression in the Adult Mouse Brain.
Hwang SN, Kim JC, Kim SY. | 01/11/2020 |
| The protein and mRNA levels of GRIM-19 were markedly decreased on Day 4 of pregnancy, but there was no change in GRIM-19 levels in a group of pseudopregnant mice. Overexpression of GRIM-19 decreased the adhesion rate of RL95-2-BeWo co-cultured spheroids and increased apoptosis. | GRIM-19, a gene associated with retinoid-interferon-induced mortality, affects endometrial receptivity and embryo implantation.
Yang Y, Sun Y, Cheng L, Li A, Shen Y, Jiang L, Deng X, Chao L. | 07/21/2018 |
| At the basal state, a moderate down-regulation of NDUFA13 created a leak within complex I, resulting in a mild increase in cytoplasm localized Hydrogen Peroxide, but not superoxide. The resultant reactive oxygen species served as a second messenger and was responsible for the STAT3 dimerization and, hence, the activation of antiapoptotic signaling. | Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3.
Hu H, Nan J, Sun Y, Zhu D, Xiao C, Wang Y, Zhu L, Wu Y, Zhao J, Wu R, Chen J, Yu H, Hu X, Zhu W, Wang J., Free PMC Article | 06/30/2018 |
| iNGR-GRIM-19 has an efficient antitumor activity in vitro and in vivo, and might be a promising agent for the treatment of colorectal cancer. | Antitumor activity of iNGR-GRIM-19 in colorectal cancer.
Pang L, Xia Y, Wang D, Meng X. | 12/2/2017 |
| Transplantation from GRIM19-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1) but promoted the expression of regulator of calcineurin (RCAN)3 while downregulating NFAT-dependent cytokine gene expression. | GRIM19 ameliorates acute graft-versus-host disease (GVHD) by modulating Th17 and Treg cell balance through down-regulation of STAT3 and NF-AT activation.
Park MJ, Lee SH, Lee SH, Kim EK, Lee EJ, Moon YM, La Cho M., Free PMC Article | 10/21/2017 |
| NDUFA13 deficiency may be associated with asthenozoospermia through the disturbance of spermatozoa mitochondrial membrane potential and by increasing apoptosis and intracellular reactive oxygen species | Expression of NDUFA13 in asthenozoospermia and possible pathogenesis.
Yang Y, Cheng L, Wang Y, Han Y, Liu J, Deng X, Chao L. | 08/19/2017 |
| GRIM-19 may play important roles in mouse oogenesis and early embryonic development and implantation. | Downregulation of gene expression and activity of GRIM-19 affects mouse oocyte viability, maturation, embryo development and implantation.
Chao L, Wang X, Yang Y, Cui W, Xu J, Chen H, Hao A, Deng X., Free PMC Article | 12/5/2015 |
| overexpression of GRIM-19 improved the clinical and histologic features of collagen-induced arthritis and also inhibited osteoclast formation. | Gene associated with retinoid-interferon-induced mortality 19 attenuates murine autoimmune arthritis by regulation of th17 and treg cells.
Moon YM, Lee J, Lee SY, Her YM, Ryu JG, Kim EK, Son HJ, Kwok SK, Ju JH, Yang CW, Park SH, Kim HY, Cho ML. | 05/3/2014 |
| The deletion of a single copy of the Grim-19 gene was sufficient to promote carcinogenesis and formation of invasive squamous cell carcinomas. | Monoallelic loss of tumor suppressor GRIM-19 promotes tumorigenesis in mice.
Kalakonda S, Nallar SC, Jaber S, Keay SK, Rorke E, Munivenkatappa R, Lindner DJ, Fiskum GM, Kalvakolanu DV., Free PMC Article | 01/4/2014 |
| Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis | Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis.
Nallar SC, Kalakonda S, Lindner DJ, Lorenz RR, Lamarre E, Weihua X, Kalvakolanu DV., Free PMC Article | 05/18/2013 |
| in vitro nona-arginine-GRIM19 treatment of constitutively activated STAT3 (STAT3c) cancer cells significantly reduced STAT3-dependent transcription. | Overexpression of GRIM-19 in cancer cells suppresses STAT3-mediated signal transduction and cancer growth.
Okamoto T, Inozume T, Mitsui H, Kanzaki M, Harada K, Shibagaki N, Shimada S. | 11/27/2010 |
| Data show that restoration of GRIM-19 levels reestablishes the control over STAT3-dependent gene expression and tumor growth in vivo. | Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers.
Zhou Y, Li M, Wei Y, Feng D, Peng C, Weng H, Ma Y, Bao L, Nallar S, Kalakonda S, Xiao W, Kalvakolanu DV, Ling B., Free PMC Article | 01/21/2010 |
| GRIM-19 inhibits v-Src-induced cell motility by interfering with cytoskeletal restructuring. | GRIM-19 inhibits v-Src-induced cell motility by interfering with cytoskeletal restructuring.
Sun P, Nallar SC, Kalakonda S, Lindner DJ, Martin SS, Kalvakolanu DV., Free PMC Article | 01/21/2010 |
| results collectively indicate that viral interferon regulatory factor 1 modulates interferon/retinoic acid-cell death signals via interactions with GRIM19 | Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death.
Seo T, Lee D, Shim YS, Angell JE, Chidambaram NV, Kalvakolanu DV, Choe J., Free PMC Article | 01/21/2010 |
| GRIM-19 suppresses constitutive STAT3-induced cellular transformation in vitro and in vivo by down-regulating the expression of a number of cellular genes involved in cell proliferation and apoptosis | Tumor-suppressive activity of the cell death activator GRIM-19 on a constitutively active signal transducer and activator of transcription 3.
Kalakonda S, Nallar SC, Lindner DJ, Hu J, Reddy SP, Kalvakolanu DV. | 01/21/2010 |
| GRIM-19 is an inhibitor of signal transducer and activator of transcription 3 | The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3.
Zhang J, Yang J, Roy SK, Tininini S, Hu J, Bromberg JF, Poli V, Stark GR, Kalvakolanu DV., Free PMC Article | 01/21/2010 |