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    SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 6714, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis.

    The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis.
    Zhao W, Ouyang C, Zhang L, Wang J, Zhang J, Zhang Y, Huang C, Xiao Q, Jiang B, Lin F, Zhang C, Zhu M, Xie C, Huang X, Zhang B, Zhao W, He J, Chen S, Liu X, Lin D, Li Q, Wang Z., Free PMC Article

    09/9/2024
    Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309.

    Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309.
    Ruan Z, Lee J, Li Y, Du J, Lü W., Free PMC Article

    09/4/2024
    Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.

    Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
    Moye AL, Dost AF, Ietswaart R, Sengupta S, Ya V, Aluya C, Fahey CG, Louie SM, Paschini M, Kim CF., Free PMC Article

    08/13/2024
    Role of the GRP78-c-Src signaling pathway on osteoblast differentiation of periodontal ligament fibroblasts induced by cyclic mechanical stretch.

    Role of the GRP78-c-Src signaling pathway on osteoblast differentiation of periodontal ligament fibroblasts induced by cyclic mechanical stretch.
    Hu J, Cui Z, Huang K, Su R, Zhao S., Free PMC Article

    08/12/2024
    Regulation of Src tumor activity by its N-terminal intrinsically disordered region.

    Regulation of Src tumor activity by its N-terminal intrinsically disordered region.
    Aponte E, Lafitte M, Sirvent A, Simon V, Barbery M, Fourgous E, Boublik Y, Maffei M, Armand F, Hamelin R, Pannequin J, Fort P, Pons M, Roche S., Free PMC Article

    07/26/2024
    FAXC interacts with ANXA2 and SRC in mitochondria and promotes tumorigenesis in cholangiocarcinoma.

    FAXC interacts with ANXA2 and SRC in mitochondria and promotes tumorigenesis in cholangiocarcinoma.
    Fujimori H, Shima-Nakamura M, Kanno SI, Shibuya-Takahashi R, Mochizuki M, Mizuma M, Unno M, Wakui Y, Abue M, Iwai W, Fukushi D, Satoh K, Yamaguchi K, Shindo N, Yasuda J, Tamai K., Free PMC Article

    07/8/2024
    LINC08148 promotes the caveola-mediated endocytosis of Zika virus through upregulating transcription of Src.

    LINC08148 promotes the caveola-mediated endocytosis of Zika virus through upregulating transcription of Src.
    Huo Z, Zhu X, Peng Q, Chen C, Yang X, Huang C, Xiang Y, Tian Q, Liu J, Liu C, Zhang P.,

    06/14/2024
    Oxidative Stress Participates in Age-Related Cataract Formation by Disrupting Connection between Lens Epithelial Cells through c-Src/VEGF Pathway.

    Oxidative Stress Participates in Age-Related Cataract Formation by Disrupting Connection between Lens Epithelial Cells through c-Src/VEGF Pathway.
    Zhang L, Zhang ZF, Hui YN, He F, Guan XR, Zhou J.

    03/25/2024
    ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.

    ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.
    Cheng S, Li M, Zheng W, Li C, Hao Z, Dai Y, Wang J, Zhuo J, Zhang L.

    03/14/2024
    Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression.

    Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression.
    Deng Y, Hou Z, Li Y, Yi M, Wu Y, Zheng Y, Yang F, Zhong G, Hao Q, Zhai Z, Wang M, Ma X, Kang H, Ji F, Dong C, Liu H, Dai Z., Free PMC Article

    02/20/2024
    TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization.

    TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization.
    Tang J, Kang Y, Zhou Y, Shang N, Li X, Wang H, Lan J, Wang S, Wu L, Peng Y., Free PMC Article

    02/9/2024
    c-Src regulates delta-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6.

    c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6.
    Jiang Y, Li L, Wu R, Wu L, Zhang B, Wang JZ, Liu R, Liu F, Wang J, Wang X., Free PMC Article

    01/31/2024
    Compartment-specific multiomic profiling identifies SRC and GNAS as candidate drivers of epithelial-to-mesenchymal transition in ovarian carcinosarcoma.

    Compartment-specific multiomic profiling identifies SRC and GNAS as candidate drivers of epithelial-to-mesenchymal transition in ovarian carcinosarcoma.
    Herrington CS, Oswald AJ, Stillie LJ, Croy I, Churchman M, Hollis RL., Free PMC Article

    01/29/2024
    An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function.

    An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function.
    Cuesta-Hernández HN, Contreras J, Soriano-Maldonado P, Sánchez-Wandelmer J, Yeung W, Martín-Hurtado A, Muñoz IG, Kannan N, Llimargas M, Muñoz J, Plaza-Menacho I., Free PMC Article

    10/24/2023
    Identification and functional validation of SRC and RAPGEF1 as new direct targets of miR-203, involved in regulation of epidermal homeostasis.

    Identification and functional validation of SRC and RAPGEF1 as new direct targets of miR-203, involved in regulation of epidermal homeostasis.
    Golebiewski C, Gastaldi C, Vieu DL, Mari B, Rezzonico R, Bernerd F, Marionnet C., Free PMC Article

    09/12/2023
    The activated CD36-Src axis promotes lung adenocarcinoma cell proliferation and actin remodeling-involved metastasis in high-fat environment.

    The activated CD36-Src axis promotes lung adenocarcinoma cell proliferation and actin remodeling-involved metastasis in high-fat environment.
    Liu LZ, Wang B, Zhang R, Wu Z, Huang Y, Zhang X, Zhou J, Yi J, Shen J, Li MY, Dong M., Free PMC Article

    08/25/2023
    SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.

    SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.
    Xu R, Song J, Ruze R, Chen Y, Yin X, Wang C, Zhao Y., Free PMC Article

    08/9/2023
    The c-Src/LIST Positive Feedback Loop Sustains Tumor Progression and Chemoresistance.

    The c-Src/LIST Positive Feedback Loop Sustains Tumor Progression and Chemoresistance.
    Wang X, Wang B, Li F, Li X, Guo T, Gao Y, Wang D, Huang W., Free PMC Article

    07/28/2023
    PELP1 and SRC kinase as important molecules in the estrogen-mediated pathway in human testis and epididymis.

    PELP1 and SRC kinase as important molecules in the estrogen-mediated pathway in human testis and epididymis.
    Skibińska I, Andrusiewicz M, Jendraszak M, Żbikowska A, Żaba C, Kotwicka M.

    06/23/2023
    MiR-654-3p targets SRC to suppress tumor growth in non-small cell lung cancer.

    MiR-654-3p targets SRC to suppress tumor growth in non-small cell lung cancer.
    Pang M, Jiang Y, Huang Y, Ren B, He L, Jiang L.

    06/22/2023
    Casein kinase 1 controls the shuttling of epidermal growth factor receptor and estrogen receptor in endometrial carcinoma induced by breast cancer hormonal therapy: Relevance of GPER1/Src.

    Casein kinase 1 controls the shuttling of epidermal growth factor receptor and estrogen receptor in endometrial carcinoma induced by breast cancer hormonal therapy: Relevance of GPER1/Src.
    Hoang LN, Lee SJ.

    06/14/2023
    FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC.

    FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC.
    Chen X, Chen J, Feng W, Huang W, Wang G, Sun M, Luo X, Wang Y, Nie Y, Fan D, Wu K, Xia L., Free PMC Article

    03/21/2023
    Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality.

    Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality.
    Skibińska I, Andrusiewicz M, Jendraszak M, Żbikowska A, Jędrzejczak P, Kotwicka M., Free PMC Article

    02/28/2023
    Disordered Domain Shifts the Conformational Ensemble of the Folded Regulatory Domain of the Multidomain Oncoprotein c-Src.

    Disordered Domain Shifts the Conformational Ensemble of the Folded Regulatory Domain of the Multidomain Oncoprotein c-Src.
    Gurumoorthy V, Shrestha UR, Zhang Q, Pingali SV, Boder ET, Urban VS, Smith JC, Petridis L, O'Neill H.

    02/22/2023
    Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer stemness and metastasis in triple-negative breast cancer.

    Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer stemness and metastasis in triple-negative breast cancer.
    Zou H, Luo J, Guo Y, Tong T, Liu Y, Chen Y, Xiao Y, Ye L, Zhu C, Deng L, Wang B, Pan Y, Li P., Free PMC Article

    02/11/2023
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