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    SPN sialophorin [ Homo sapiens (human) ]

    Gene ID: 6693, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CD43 (sialophorin) is involved in the induction of extracellular matrix remodeling and angiogenesis by lung cancer cells.

    CD43 (sialophorin) is involved in the induction of extracellular matrix remodeling and angiogenesis by lung cancer cells.
    Vega-Mendoza D, Cañas-Linares A, Flores-Alcantar A, Espinosa-Neira R, Melchy-Perez E, Vera-Estrella R, Auvynet C, Rosenstein Y.

    11/13/2021
    CD43 in the malignant flow cytometry laboratory in 2020.

    CD43 in the malignant flow cytometry laboratory in 2020.
    Sorigue M.

    09/4/2021
    Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells.

    Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells.
    Yoshimura A, Asahina Y, Chang LY, Angata T, Tanaka H, Kitajima K, Sato C., Free PMC Article

    08/28/2021
    Determination of CD43 and CD200 surface expression improves accuracy of B-cell lymphoma immunophenotyping.

    Determination of CD43 and CD200 surface expression improves accuracy of B-cell lymphoma immunophenotyping.
    Hoffmann J, Rother M, Kaiser U, Thrun MC, Wilhelm C, Gruen A, Niebergall U, Meissauer U, Neubauer A, Brendel C.

    08/21/2021
    Virion-incorporated host transmembrane proteins PSGL-1 and CD43 inhibit attachment of HIV-1 particles to target cells. Co-clustering of HIV-1 structural protein Gag with PSGL-1 and subsequent progeny virion release contribute to depletion of PSGL-1 from an infected cell surface. In addition, study reports a previously unidentified role for Gag in viral down-regulation of antiviral proteins.

    Virion-incorporated PSGL-1 and CD43 inhibit both cell-free infection and transinfection of HIV-1 by preventing virus-cell binding.
    Murakami T, Carmona N, Ono A., Free PMC Article

    07/25/2020
    Our results point to the usefulness of CD43 and CD49d, two markers commonly present in B-cell chronic lymphoproliferative disorders (B-CLPD) diagnosis panels, in the identification of dysplastic phenotypic features in the erythroid lineage.

    CD43 and CD49d from the B-Cell Chronic Lymphoproliferative Disorders Diagnostic Panel Are Useful to Detect Erythroid Dysplasia.
    Oliveira M, Laranjeira P, Fortuna M, Bártolo R, Ribeiro A, Santos M, Cortesão E, Marques G, Sarmento-Ribeiro AB, Vitória H, Ribeiro L, Paiva A.

    07/4/2020
    our data indicate that DLBCL patients with CD5/CD43 coexpression represent a specific subgroup with a significantly worse prognosis than those expressing either marker alone.

    Coexpression of CD5 and CD43 predicts worse prognosis in diffuse large B-cell lymphoma.
    Ma XB, Zhong YP, Zheng Y, Jiang J, Wang YP., Free PMC Article

    11/16/2019
    this study shows that CD43 regulates Th17 cell ICAM1 dependent adhesion, apical migration and transendothelial migration

    Sialomucin CD43 regulates T helper type 17 cell intercellular adhesion molecule 1 dependent adhesion, apical migration and transendothelial migration.
    Velázquez FE, Anastasiou M, Carrillo-Salinas FJ, Ngwenyama N, Salvador AM, Nevers T, Alcaide P., Free PMC Article

    11/2/2019
    CD39, CD43, CD81, and CD95 expressions appear to be helpful to distinguish CD10(+) BCL.

    The importance of CD39, CD43, CD81, and CD95 expression for differentiating B cell lymphoma by flow cytometry.
    Cardoso CC, Auat M, Santos-Pirath IM, Rudolf-Oliveira RCM, da Silva JP, Lange BG, Siegel D, de Moraes ACR, Del Moral JAG, Santos-Silva MC.

    05/11/2019
    The frequency of CD43-positivity increases sharply with the Moreau score.

    Expression of CD43 in chronic lymphoproliferative leukemias.
    Sorigue M, Juncà J, Sarrate E, Grau J.

    05/11/2019
    CD43 expression was 95.7% in atypical chronic lymphocytic leukemia cases.

    The Role of CD200 and CD43 Expression in Differential Diagnosis between Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma.
    Falay M, Afacan Öztürk B, Güneş K, Kalpakçı Y, Dağdaş S, Ceran F, Özet G., Free PMC Article

    10/6/2018
    most non-hematopoietic neoplasms are negative for CD43 expression

    Evaluation of CD43 expression in non-hematopoietic malignancies.
    Batdorf BH, Kroft SH, Hosking PR, Harrington AM, Mackinnon AC, Olteanu H.

    05/5/2018
    this study identifies a new signaling pathway for CD43 through the regulation of alternative functions of pyruvate kinase isoform M2, favoring cell survival following activation

    An alternative mode of CD43 signal transduction activates pro-survival pathways of T lymphocytes.
    Bravo-Adame ME, Vera-Estrella R, Barkla BJ, Martínez-Campos C, Flores-Alcantar A, Ocelotl-Oviedo JP, Pedraza-Alva G, Rosenstein Y., Free PMC Article

    05/27/2017
    Forty percent of adenoid cystic carcinomas showed staining for CD43, while no cases of basal cell carcinoma were positive

    CD117 and CD43 are useful adjuncts in the distinction of adenoid cystic carcinoma from adenoid basal cell carcinoma.
    Dessauvagie BF, Wood BA.

    09/5/2015
    CD43 expression is a novel adverse prognostic factor for patients with diffuse large B-cell lymphomas

    CD43 expression in diffuse large B-cell lymphoma, not otherwise specified: CD43 is a marker of adverse prognosis.
    Ma XB, Zheng Y, Yuan HP, Jiang J, Wang YP.

    06/20/2015
    CD43 polymorphisms are associated with TB susceptibility.

    Common polymorphisms in the CD43 gene region are associated with tuberculosis disease and mortality.
    Campo M, Randhawa AK, Dunstan S, Farrar J, Caws M, Bang ND, Lan NN, Hong Chau TT, Horne DJ, Thuong NT, Thwaites GE, Hawn TR., Free PMC Article

    04/25/2015
    Host membrane protein PSGL-1, CD43, and CD44 association with assembling HIV-1 Gag is driven by polybasic sequences present in the cytoplasmic tails of the membrane proteins and in Gag.

    Basic motifs target PSGL-1, CD43, and CD44 to plasma membrane sites where HIV-1 assembles.
    Grover JR, Veatch SL, Ono A., Free PMC Article

    03/21/2015
    When used as vaccine in mice, the 2/165 phagotope raised antibodies against the UN1/CD43 antigen, indicating that the 2/165 phagotope mimicked the UN1 antigen structure, and could represent a novel immunogen for cancer immunotherapy

    Cancer-associated CD43 glycoforms as target of immunotherapy.
    Tuccillo FM, Palmieri C, Fiume G, de Laurentiis A, Schiavone M, Falcone C, Iaccino E, Galandrini R, Capuano C, Santoni A, D'Armiento FP, Arra C, Barbieri A, Dal Piaz F, Venzon D, Bonelli P, Buonaguro FM, Scala I, Mallardo M, Quinto I, Scala G., Free PMC Article

    11/22/2014
    CD43 promotes cells transformation by preventing merlin-mediated contact inhibition of growth.

    CD43 promotes cells transformation by preventing merlin-mediated contact inhibition of growth.
    Camacho-Concha N, Olivos-Ortiz A, Nuñez-Rivera A, Pedroza-Saavedra A, Gutierrez-Xicotencatl L, Rosenstein Y, Pedraza-Alva G., Free PMC Article

    08/30/2014
    We conclude that CD43 is an adverse prognostic marker in DLBCL, and is preferentially expressed in the non-GCB subgroup.

    CD43 expression is associated with inferior survival in the non-germinal centre B-cell subgroup of diffuse large B-cell lymphoma.
    Mitrovic Z, Iqbal J, Fu K, Smith LM, Bast M, Greiner TC, Aoun P, Armitage JO, Vose JM, Weisenburger DD, Chan WC.

    08/31/2013
    CD43 regulates the threshold for T cell activation by targeting Cbl functions.

    CD43 regulates the threshold for T cell activation by targeting Cbl functions.
    Pedraza-Alva G, Mérida LB, del Rio R, Fierro NA, Cruz-Muñoz ME, Olivares N, Melchy E, Igras V, Holländer GA, Burakoff SJ, Rosenstein Y., Free PMC Article

    08/31/2013
    Taken together, these results show that elevated calcium levels induce CD43 capping, and macrophages remove the cells if their nucleolin receptors can bind to the poly-N-acetyllactosaminyl chains of capped CD43.

    Macrophage recognition of cells with elevated calcium is mediated by carbohydrate chains of CD43.
    Miki Y, Oguri E, Hirano K, Beppu M.

    07/6/2013
    Targeting CD43 in A549 lung cancer cells, increased homotypic adhesion, decreased heterotypic adhesion and transendothelial migration, increased susceptibility to apoptosis and increased vulnerability to lysis by NK cells

    CD43 in the nucleus and cytoplasm of lung cancer is a potential therapeutic target.
    Fu Q, Cash SE, Andersen JJ, Kennedy CR, Oldenburg DG, Zander VB, Foley GR, Simon Shelley C.

    05/25/2013
    results suggest that, despite the high CD43 expression in both tumorous and nontumorous Langerhans cells (LCs), the JL1 epitope of CD43 is exposed in immature and neoplastic LCs.

    Use of the JL1 epitope, which encompasses the nonglycosylation site of CD43, as a marker of immature/neoplastic Langerhans cells.
    Park HJ, Jeon YK, Lee AH, Oh YH, Park SH, Jung KC.

    09/22/2012
    Compared to healthy controls, both CD43 mRNA and protein expressions were reduced in T cells from patients with SLE, and were inversely correlated with IgG.

    Abnormal expression of CD43 in patients with systemic lupus erythematosus and its clinical significance.
    Xia LX, Ding X, Li X, Zhang FC, Tang FL, Zhang X, Ba DN, He W.

    09/22/2012
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