| DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response. | DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response.
Li M, Wu X, Chen M, Hao S, Yu Y, Li X, Zhao E, Xu M, Yu Z, Wang Z, Xu N, Jin C, Yin Y., Free PMC Article | 03/12/2024 |
| ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions. | ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions.
Jeong H, Hong EH, Ahn JH, Cho J, Jeong JH, Kim CW, Yoon BI, Koo JH, Park YY, Yang YM, Iwawaki T, Vallance BA, Chang SY, Ko HJ., Free PMC Article | 03/7/2023 |
| Loss of ERdj5 exacerbates oxidative stress in mice with alcoholic liver disease via suppressing Nrf2. | Loss of ERdj5 exacerbates oxidative stress in mice with alcoholic liver disease via suppressing Nrf2.
Hong DG, Song GY, Eom CB, Ahn JH, Kim SM, Shim A, Han YH, Roh YS, Han CY, Bae EJ, Ko HJ, Yang YM. | 05/21/2022 |
| AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity. | AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity.
Aguilà M, Bellingham J, Athanasiou D, Bevilacqua D, Duran Y, Maswood R, Parfitt DA, Iwawaki T, Spyrou G, Smith AJ, Ali RR, Cheetham ME., Free PMC Article | 08/7/2021 |
| ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin. | ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin.
Kim MS, Yi EJ, Kim YI, Kim SH, Jung YS, Kim SR, Iwawaki T, Ko HJ, Chang SY., Free PMC Article | 10/24/2020 |
| Ablation of the Chaperone Protein ERdj5 Results in a Sjogren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients. | Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients.
Apostolou E, Moustardas P, Iwawaki T, Tzioufas AG, Spyrou G., Free PMC Article | 09/26/2020 |
| These results identify ERdj5 as one of the master regulators of ER calcium homeostasis and thus shed light on the importance of cross talk among redox, Ca(2+), and protein homeostasis in the ER. | Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5.
Ushioda R, Miyamoto A, Inoue M, Watanabe S, Okumura M, Maegawa KI, Uegaki K, Fujii S, Fukuda Y, Umitsu M, Takagi J, Inaba K, Mikoshiba K, Nagata K., Free PMC Article | 02/3/2018 |
| study identified the redox partners of ERdj5 from the mouse epididymis; findings show that ERdj5 interacted with two of the identified proteins via formation of intermolecular disulfide bond | Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue.
Kadokura H, Saito M, Tsuru A, Hosoda A, Iwawaki T, Inaba K, Kohno K. | 12/14/2013 |
| Data suggest that ERdj5 contributes to ER protein quality control in the salivary gland. | Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland.
Hosoda A, Tokuda M, Akai R, Kohno K, Iwawaki T. | 01/25/2010 |
| study found that an endoplasmic reticulum (ER) protein ERdj5 had a reductase activity, cleaved the disulfide bonds of misfolded proteins & accelerated ER-associated degradation through its physical and functional associations with EDEM & BiP | ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER.
Ushioda R, Hoseki J, Araki K, Jansen G, Thomas DY, Nagata K. | 01/21/2010 |
| JPDI may have roles in folding of some proteins in the ER, chaperoning by BiP and formation of proper disulfide bonds | JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs.
Hosoda A, Kimata Y, Tsuru A, Kohno K. | 01/21/2010 |