| Specificity protein 1/3 regulate T-cell acute lymphoblastic leukemia cell proliferation and apoptosis through beta-catenin by acting as targets of miR-495-3p. | Specificity protein 1/3 regulate T-cell acute lymphoblastic leukemia cell proliferation and apoptosis through β-catenin by acting as targets of miR-495-3p.
Zheng B, Geng Y, Li Y, Huang H, Liu A. | 08/14/2024 |
| SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells. | SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells.
Tian P, Du D, Yang L, Zhou N, Tao L., Free PMC Article | 02/21/2024 |
| Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible Relevance to Cancer and the Lytic Cycle of Kaposi's Sarcoma-Associated Herpesvirus. | Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible Relevance to Cancer and the Lytic Cycle of Kaposi's Sarcoma-Associated Herpesvirus.
Chen LY, Chen LW, Hung CH, Lin CL, Wang SS, Chang PJ., Free PMC Article | 03/12/2022 |
| A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear beta-catenin levels. | A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels.
Wen S, Qin Y, Wang R, Yang L, Zeng H, Zhu P, Li Q, Qiu Y, Chen S, Liu Y, Hou Y, Tang X, Liu M, Tu G., Free PMC Article | 10/16/2021 |
| SP3 is associated with migration, invasion, and Akt/PKB signalling in MDA-MB-231 breast cancer cells. | SP3 is associated with migration, invasion, and Akt/PKB signalling in MDA-MB-231 breast cancer cells.
Mansour MA. | 07/17/2021 |
| Sp3 Transcription Factor Cooperates with the Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein To Synergistically Activate Specific Viral and Cellular Gene Promoters. | Sp3 Transcription Factor Cooperates with the Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein To Synergistically Activate Specific Viral and Cellular Gene Promoters.
Chen LY, Chen LW, Peng KT, Hung CH, Chang PJ, Wang SS., Free PMC Article | 11/28/2020 |
| The authors identified that human papillomavirus type 8 E7 protein exerts control over cellular gene expression through Sp1/3 binding motifs, which may contribute to the virus-mediated keratinocyte transformation and subsequent fibronectin-dependent invasion. | HPV8 activates cellular gene expression mainly through Sp1/3 binding sites.
Kirschberg M, Heuser S, Syed AS, Steger G, Majewski S, Hufbauer M, Akgül B. | 04/11/2020 |
| These findings suggest that the transcription of the b4GalT3 gene is regulated by differential DNA binding of Sp3 and Sp1 in neuroblastoma and lung cancer. The increased expression of b4GalT3 in neuroblastoma may be ascribed to the enhanced expression of Sp3, which is observed for various cancers. | Transcription of human β4-galactosyltransferase 3 is regulated by differential DNA binding of Sp1/Sp3 in SH-SY5Y human neuroblastoma and A549 human lung cancer cell lines.
Tange R, Tomatsu T, Sato T. | 06/15/2019 |
| expression of the nearby cyclindependent kinase inhibitor 1C (CDKN1C) gene was revealed to be upregulated after SP3 knockdown in cells that possessed non-risk alleles. This suggests that CDKN1C is potentially one of the functional targets of SNP rs163184, which modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a | A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression.
Hiramoto M, Udagawa H, Ishibashi N, Takahashi E, Kaburagi Y, Miyazawa K, Funahashi N, Nammo T, Yasuda K., Free PMC Article | 07/28/2018 |
| Sp1, Sp3 and Sp4 are non-oncogene addiction (NOA) genes and are attractive drug targets for individual and combined cancer chemotherapies. | Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.
Hedrick E, Cheng Y, Jin UH, Kim K, Safe S., Free PMC Article | 12/9/2017 |
| High SP3 expression is associated with hepatocellular carcinoma. | The miR-491-3p/Sp3/ABCB1 axis attenuates multidrug resistance of hepatocellular carcinoma.
Zhao Y, Qi X, Chen J, Wei W, Yu C, Yan H, Pu M, Li Y, Miao L, Li C, Ren J. | 11/4/2017 |
| we established a new regulatory model of COL1A1 regulation by HIF-1, and bring out its relationship with Sp3 transcription factor. In a fundamental level, these findings give insights in the mechanisms controlling COL1A1 gene expression. | Hypoxia inducible factor 1 alpha down-regulates type i collagen through Sp3 transcription factor in human chondrocytes.
Duval E, Bouyoucef M, Leclercq S, Baugé C, Boumédiene K. | 09/2/2017 |
| Data indicate that the antitumor activity of trefoil factor 2 (TFF2) is mediated by an interaction with the transcription factor Sp3 (Sp3) in gastric cancer cells. | Trefoil factor family 2 expression inhibits gastric cancer cell growth and invasion in vitro via interactions with the transcription factor Sp3.
Cai Y, Yi M, Chen D, Liu J, Guleng B, Ren J, Shi H., Free PMC Article | 03/25/2017 |
| demonstrate that a 186bp region is the minimal essential region and that Sp3-GC1 binding is essential to the basal expression of KLF5 | Minimal essential region for krüppel-like factor 5 expression and the regulation by specificity protein 3-GC box binding.
Mihara N, Chiba T, Yamaguchi K, Sudo H, Yagishita H, Imai K. | 02/4/2017 |
| Sp1 and Sp3 are not only essential for the basal transcription of the ek1 gene, their accessibility to the target site on the ek1 promoter is regulated by histone protein modification in a cell line dependent manner. | Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells.
Kuan CS, See Too WC, Few LL., Free PMC Article | 07/30/2016 |
| Human SP1 and SP3 transcription factors regulate MALAT1 expression in hepatocellular carcinoma. | Sp1 cooperates with Sp3 to upregulate MALAT1 expression in human hepatocellular carcinoma.
Huang Z, Huang L, Shen S, Li J, Lu H, Mo W, Dang Y, Luo D, Chen G, Feng Z. | 07/30/2016 |
| result indicated that promoter binding by Sp1/Sp3 was essential, but not a limiting step, for hTERT transcription | Human Telomerase Reverse Transcriptase (hTERT) Transcription Requires Sp1/Sp3 Binding to the Promoter and a Permissive Chromatin Environment.
Cheng D, Zhao Y, Wang S, Jia W, Kang J, Zhu J., Free PMC Article | 05/14/2016 |
| Sp3 was found to be a major regulator of BNIP3 in prostate cancer. | Transcriptional regulation of BNIP3 by Sp3 in prostate cancer.
Huang Y, Shen P, Chen X, Chen Z, Zhao T, Chen N, Gong J, Nie L, Xu M, Li X, Zeng H, Zhou Q. | 04/30/2016 |
| stimulates CCR7 expression during the course of dendritic cell maturation | NFAT-1, Sp-1, Sp-3, and miR-21: New regulators of chemokine C receptor 7 expression in mature human dendritic cells.
Al Akoum C, Akl I, Rouas R, Fayyad-Kazan M, Falha L, Renno T, Burny A, Lewalle P, Fayyad-Kazan H, Badran B. | 02/27/2016 |
| O-GlcNAc modification of Sp3 and Sp4, but not Sp2 transcription factors negatively regulates their transcriptional activities. | O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.
Ha C, Lim K. | 02/6/2016 |
| characterized two evolutionary highly conserved cis-regulatory modules (CRMs) within the proximal promoter each composed of one binding site for the transcription factors SP1 and SP3 as well as for the nuclear transcription factor Y | Functional interplay of SP family members and nuclear factor Y is essential for transcriptional activation of the human Calreticulin gene.
Schardt JA, Keller M, Seipel K, Pabst T. | 10/31/2015 |
| These results suggest that XT-1 expression is refractory to the disease process and to inhibition by inflammatory cytokines and that signaling through AP-1, Sp1, and Sp3 is important in the maintenance of XT-1 levels in NP cells. | Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3.
Ye W, Zhou J, Markova DZ, Tian Y, Li J, Anderson DG, Shapiro IM, Risbud MV., Free PMC Article | 09/26/2015 |
| A novel GC-rich element (GRE) spanning -101/-66 sufficient for VEGFR3 transcription and activated by Sp1 and Sp3, respectively, was identified. | Transcription of the vascular endothelial growth factor receptor-3 (VEGFR3) gene is regulated by the zinc finger proteins Sp1 and Sp3 and is under epigenetic control: transcription of vascular endothelial growth factor receptor 3.
Hertel J, Hirche C, Wissmann C, Ebert MP, Höcker M. | 11/29/2014 |
| Results demonstrate that Sp1 and Sp3 transcription factors are the primary determinants for activating basal transcription of the ABCG2 gene and play an important role in maintaining the side population phenotype of lung cancer cells. | Transcription factors Sp1 and Sp3 regulate expression of human ABCG2 gene and chemoresistance phenotype.
Yang WJ, Song MJ, Park EY, Lee JJ, Park JH, Park K, Park JH, Kim HP., Free PMC Article | 06/7/2014 |
| Sp1 and Sp3 are functionally involved as transcriptional integrators regulating the basal expression of the derived microsomal epoxide hydrolase E1b variant transcript. | Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter.
Su S, Omiecinski CJ., Free PMC Article | 03/8/2014 |