| Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway. | Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway.
Zheng R, Zhu P, Gu J, Ni B, Sun H, He K, Bian J, Shao Y, Du J. | 02/19/2022 |
| Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro. | Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro.
Da CM, Liao HY, Deng YS, Zhao GH, Ma L, Zhang HH. | 01/22/2022 |
| Sp2 promotes invasion and metastasis of hepatocellular carcinoma by targeting TRIB3 protein. | Sp2 promotes invasion and metastasis of hepatocellular carcinoma by targeting TRIB3 protein.
Zhu Y, Cui J, Liu J, Hua W, Wei W, Sun G., Free PMC Article | 09/4/2021 |
| This study presented that a Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease. | Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease.
Marín-Muñoz J, Noguera-Perea MF, Gómez-Tortosa E, López-Motos D, Antequera-Torres M, Martínez-Herrada B, Manzanares-Sánchez S, Vivancos-Moreau L, Legaz-García A, Rábano-Gutiérrez Del Arroyo A, Antúnez-Almagro C. | 02/3/2018 |
| SP2 recognized binding motifs in the human RORgammaT promoter, which was critical for maintaining expression. SP2 was necessary for maximum IL-17 expression in in vitro-differentiated Th17 cells. SP 2 plays a role in Th17-dependent physiologic and pathologic immune responses. | Expression of human gene coding RORγT receptor depends on the Sp2 transcription factor.
Ratajewski M, Walczak-Drzewiecka A, Gorzkiewicz M, Sałkowska A, Dastych J. | 09/16/2017 |
| O-GlcNAc modification of Sp3 and Sp4, but not Sp2 transcription factors negatively regulates their transcriptional activities. | O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.
Ha C, Lim K. | 02/6/2016 |
| Sp2 is up-regulated in gastric cancer tissues | miR-638 suppresses cell proliferation in gastric cancer by targeting Sp2.
Zhao LY, Yao Y, Han J, Yang J, Wang XF, Tong DD, Song TS, Huang C, Shao Y. | 10/11/2014 |
| Data show that three Sp1 motifs located between -148 and -42bp upstream of the first exon were important in basic as well as in DA-induced NSMase2 promoter activity. | Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin.
Ito H, Murakami M, Furuhata A, Gao S, Yoshida K, Sobue S, Hagiwara K, Takagi A, Kojima T, Suzuki M, Banno Y, Tanaka K, Tamiya-Koizumi K, Kyogashima M, Nozawa Y, Murate T. | 03/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK., Free PMC Article | 12/2/2009 |
| Despite the absence of Sp2 in the 5'-upstream sequence of the human promoter, silencing of Sp2 by RNA interference clearly demonstrated that Sp2 is required for IFN-gamma-induced regulation of socs1 mRNA both in human and mouse. | Sp2 regulates interferon-gamma-mediated socs1 gene expression.
Letourneur M, Valentino L, Travagli-Gross J, Bertoglio J, Pierre J. | 01/21/2010 |
| has an intimate part in transcriptional regulation of the lh receptor gene. | Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases.
Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J, Robson SC, Europe-Finner GN. | 01/21/2010 |
| an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration | Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration.
Das A, Fernandez-Zapico ME, Cao S, Yao J, Fiorucci S, Hebbel RP, Urrutia R, Shah VH. | 01/21/2010 |