| TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition. | TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition.
Torres P, Rico-Rios S, Ceron-Codorniu M, Santacreu-Vilaseca M, Seoane-Miraz D, Jad Y, Ayala V, Mariño G, Beltran M, Miralles MP, Andrés-Benito P, Fernandez-Irigoyen J, Santamaria E, López-Otín C, Soler RM, Povedano M, Ferrer I, Pamplona R, Wood MJA, Varela MA, Portero-Otin M., Free PMC Article | 09/23/2024 |
| Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy. | Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy.
Liu X, Jiang L, Zeng H, Gao L, Guo S, Chen C, Liu X, Zhang M, Ma L, Li Y, Qi X, Wu Y., | 06/5/2024 |
| FAT1 inhibits AML autophagy and proliferation via downregulating ATG4B expression. | FAT1 inhibits AML autophagy and proliferation via downregulating ATG4B expression.
Zhang N, Shen MY, Meng QL, Sun HP, Fan FY, Yi H, Yang YJ. | 12/22/2023 |
| ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1. | ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1.
Xie W, Zhang C, Wang Z, Chen H, Gu T, Zhou T, Wu Y, Xia F, Li M, Wang J, Jiao R, Cui J, Jin S., Free PMC Article | 10/16/2023 |
| Involvement of acetylation of ATG4B in controlling autophagy induction. | Involvement of acetylation of ATG4B in controlling autophagy induction.
Xiong H, Sun L, Lian J, He F., Free PMC Article | 02/27/2023 |
| Targeting the MicroRNA-490-3p-ATG4B-Autophagy Axis Relieves Myocardial Injury in Ischemia Reperfusion. | Targeting the MicroRNA-490-3p-ATG4B-Autophagy Axis Relieves Myocardial Injury in Ischemia Reperfusion.
Wu Y, Mao Q, Liang X. | 11/27/2021 |
| miR-665-3p regulates autophagy by targeting ATG4B expression to relieve inflammation and apoptosis in intestinal ischemia/reperfusion. | Targeting the miR-665-3p-ATG4B-autophagy axis relieves inflammation and apoptosis in intestinal ischemia/reperfusion.
Li Z, Wang G, Feng D, Zu G, Li Y, Shi X, Zhao Y, Jing H, Ning S, Le W, Yao J, Tian X., Free PMC Article | 04/4/2020 |
| At the microtubule-actin crossover junction, ATG4B detaches LC3B from melanosomal membranes by enzymatic delipidation. | Classical autophagy proteins LC3B and ATG4B facilitate melanosome movement on cytoskeletal tracks.
Ramkumar A, Murthy D, Raja DA, Singh A, Krishnan A, Khanna S, Vats A, Thukral L, Sharma P, Sivasubbu S, Rani R, Natarajan VT, Gokhale RS., Free PMC Article | 05/12/2018 |
| ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 | ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.
Skytte Rasmussen M, Mouilleron S, Kumar Shrestha B, Wirth M, Lee R, Bowitz Larsen K, Abudu Princely Y, O'Reilly N, Sjøttem E, Tooze SA, Lamark T, Johansen T., Free PMC Article | 03/31/2018 |
| miR-34a might regulate the autophagic activity and can cause injury in ischemia reperfusion injured renal tubular epithelial cells (RTEC) via targeting Atg4B. Atg4B knockdown inhibited autophagy in RTECs. | MicroRNA-34a Suppresses Autophagy in Tubular Epithelial Cells in Acute Kidney Injury.
Liu XJ, Hong Q, Wang Z, Yu YY, Zou X, Xu LH. | 07/16/2016 |
| the ATG4B protease and autophagy play a crucial role protecting epithelial cells against bleomycin-induced stress and apoptosis | Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis.
Cabrera S, Maciel M, Herrera I, Nava T, Vergara F, Gaxiola M, López-Otín C, Selman M, Pardo A., Free PMC Article | 03/19/2016 |
| REDD1/TXNIP complex expression is sufficient to induce reactive oxygen species, suppress ATG4B activity and activate autophagy. | A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity.
Qiao S, Dennis M, Song X, Vadysirisack DD, Salunke D, Nash Z, Yang Z, Liesa M, Yoshioka J, Matsuzawa S, Shirihai OS, Lee RT, Reed JC, Ellisen LW., Free PMC Article | 03/19/2016 |
| these findings demonstrate a role for Ser-383 and Ser-392 phosphorylation of ATG4B in control of autophagy. | ATG4B (Autophagin-1) phosphorylation modulates autophagy.
Yang Z, Wilkie-Grantham RP, Yanagi T, Shu CW, Matsuzawa S, Reed JC., Free PMC Article | 02/6/2016 |
| mTOR inhibition alleviates Huntington's disease progression by inducing Atg4b-dependent autophagic flux. | Atg4b-dependent autophagic flux alleviates Huntington's disease progression.
Proenca CC, Stoehr N, Bernhard M, Seger S, Genoud C, Roscic A, Paganetti P, Liu S, Murphy LO, Kuhn R, Bouwmeester T, Galimberti I., Free PMC Article | 02/15/2014 |
| An autophagy-related gene, Atg4b, is identified as a de novo target gene of C/EBP BETA and is shown to play an important role in 3T3-L1 adipocyte differentiation. | Transactivation of Atg4b by C/EBPβ promotes autophagy to facilitate adipogenesis.
Guo L, Huang JX, Liu Y, Li X, Zhou SR, Qian SW, Liu Y, Zhu H, Huang HY, Dang YJ, Tang QQ., Free PMC Article | 10/26/2013 |
| the RNF5-mediated control of membranalATG4B reveals a novel layer in the regulation of LC3 processing and autophagy. | Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.
Kuang E, Okumura CY, Sheffy-Levin S, Varsano T, Shu VC, Qi J, Niesman IR, Yang HJ, López-Otín C, Yang WY, Reed JC, Broday L, Nizet V, Ronai ZA., Free PMC Article | 03/23/2013 |
| The Atg4b participates in polarized secretion of lysosomal contents into the extracellular space by directing lysosomes to fuse with the plasma membrane. | Autophagy proteins regulate the secretory component of osteoclastic bone resorption.
DeSelm CJ, Miller BC, Zou W, Beatty WL, van Meel E, Takahata Y, Klumperman J, Tooze SA, Teitelbaum SL, Virgin HW., Free PMC Article | 02/4/2012 |
| Genetic inactivation of mouse Atg4b resulted in amorphous globular bodies in the neuropil of the deep cerebellar nuclei and adjacent vestibular nuclei and a mild but measurable impairment of motor performance on the Rotarod. | Histopathological and neurological features of Atg4b knockout mice.
Read R, Savelieva K, Baker K, Hansen G, Vogel P. | 07/9/2011 |
| These results show that the lipidation of LC3 paralogues is involved in the completion of autophagosome formation in mammalian cells. | An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.
Fujita N, Hayashi-Nishino M, Fukumoto H, Omori H, Yamamoto A, Noda T, Yoshimori T., Free PMC Article | 01/21/2010 |
| The Apg4B/autophagin-1 protease thus serves as a processing/deconjugating enzyme for these four highly divergent mammalian Apg8 homologues, GATE-16, MAP1-LC3, GABARAP, and Apg8L. | A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L.
Hemelaar J, Lelyveld VS, Kessler BM, Ploegh HL. | 01/21/2010 |