| Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis. | Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis.
Demkova L, Bugajev V, Adamcova MK, Kuchar L, Grusanovic S, Alberich-Jorda M, Draber P, Halova I., Free PMC Article | 06/3/2024 |
| Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis. | Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis.
Brown RDR, Green CD, Weigel C, Ni B, Celi FS, Proia RL, Spiegel S., Free PMC Article | 02/1/2024 |
| Histone acetylation regulates ORMDL3 expression-mediated NLRP3 inflammasome overexpression during RSV-allergic exacerbation mice. | Histone acetylation regulates ORMDL3 expression-mediated NLRP3 inflammasome overexpression during RSV-allergic exacerbation mice.
Cheng Q, He F, Zhao W, Xu X, Shang Y, Huang W. | 12/20/2023 |
| ORMDL3-mediated bronchial epithelial pyroptosis leads to lung inflammation in obese mice with asthma. | ORMDL3‑mediated bronchial epithelial pyroptosis leads to lung inflammation in obese mice with asthma.
Liu F, Sun Y, Zhou Y, Gao Y, Song Q, Yang J, Xu C, Li G., Free PMC Article | 08/22/2023 |
| The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway. | The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway.
Shao Y, Xu Y, Di H, Shi X, Wang Y, Liu H, Song L., Free PMC Article | 05/19/2023 |
| Ormdl3 regulation of specific ceramides is dispensable for mouse beta-cell function and glucose homeostasis under obesogenic conditions. | Ormdl3 regulation of specific ceramides is dispensable for mouse β-cell function and glucose homeostasis under obesogenic conditions.
Hurley LD, Lee H, Wade G, Simcox J, Engin F., Free PMC Article | 05/3/2023 |
| Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice. | Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice.
James BN, Weigel C, Green CD, Brown RDR, Palladino END, Tharakan A, Milstien S, Proia RL, Martin RK, Spiegel S., Free PMC Article | 02/13/2023 |
| Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation. | Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation.
Song Y, Zan W, Qin L, Han S, Ye L, Wang M, Jiang B, Fang P, Liu Q, Shao C, Gong Y, Li P., Free PMC Article | 04/9/2022 |
| Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways. | Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways.
Bugajev V, Paulenda T, Utekal P, Mrkacek M, Halova I, Kuchar L, Kuda O, Vavrova P, Schuster B, Fuentes-Liso S, Potuckova L, Smrz D, Cernohouzova S, Draberova L, Bambouskova M, Draber P., Free PMC Article | 03/26/2022 |
| Pulmonary delivery of ORMDL3 short hairpin RNA - a potential tool to regulate allergen-induced airway inflammation. | Pulmonary delivery of ORMDL3 short hairpin RNA - a potential tool to regulate allergen-induced airway inflammation.
Dileepan M, Ha SG, Rastle-Simpson S, Ge XN, Greenberg YG, Wijesinghe DS, Contaifer D Jr, Rao SP, Sriramarao P. | 08/21/2021 |
| ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy-Dependent Pathway. | ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy-Dependent Pathway.
Li J, Ullah MA, Jin H, Liang Y, Lin L, Wang J, Peng X, Liao H, Li Y, Ge Y, Li L., Free PMC Article | 07/3/2021 |
| ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling. | ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling.
Bugajev V, Halova I, Demkova L, Cernohouzova S, Vavrova P, Mrkacek M, Utekal P, Draberova L, Kuchar L, Schuster B, Draber P., Free PMC Article | 06/26/2021 |
| Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3) Expression and Normalizes Ceramide Imbalance. | Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3) Expression and Normalizes Ceramide Imbalance.
Youssef M, De Sanctis JB, Shah J, Dumut DC, Hajduch M, Naumova AK, Radzioch D. | 09/12/2020 |
| ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/JNK2-MMP-9 pathway. | ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/2-MMP-9 pathway.
Wang H, Liu Y, Shi J, Cheng Z. | 07/11/2020 |
| ORMDL3 regulates systemic ceramide levels, but genetically interfering with Ormdl3 expression does not result in altered experimental asthma. | The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice.
Debeuf N, Zhakupova A, Steiner R, Van Gassen S, Deswarte K, Fayazpour F, Van Moorleghem J, Vergote K, Pavie B, Lemeire K, Hammad H, Hornemann T, Janssens S, Lambrecht BN., Free PMC Article | 06/13/2020 |
| we found that Ormdl1 and Ormdl3 function redundantly to suppress the levels of bioactive sphingolipid metabolites during myelination of the sciatic nerve | The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice.
Clarke BA, Majumder S, Zhu H, Lee YT, Kono M, Li C, Khanna C, Blain H, Schwartz R, Huso VL, Byrnes C, Tuymetova G, Dunn TM, Allende ML, Proia RL., Free PMC Article | 06/13/2020 |
| Study of diurnal expression profiles of ZPBP2/Zpbp2, gasdermin B, and ORMDL3/Ormdl3 in human and mouse tissues revealed that Ormdl3 and Zpbp2 were controlled by the circadian clock in a tissue-specific fashion provided the first evidence that disease-associated genes Zpbp2 and Ormdl3 are regulated by circadian rhythms and the Zpbp2 region influences expression of the core clock gene Nr1d1. | Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock.
Chang ML, Moussette S, Gamero-Estevez E, Gálvez JH, Chiwara V, Gupta IR, Ryan AK, Naumova AK., Free PMC Article | 04/4/2020 |
| ORMDL3 overexpression results in damaged epithelial barrier integrity, reflected by higher epithelial permeability, increased inflammatory cytokine secretion, decreased transepithelial electrical resistance and hampered expression of airway epithelium molecules. | Investigating the regulatory role of ORMDL3 in airway barrier dysfunction using in vivo and in vitro models.
Yang R, Tan M, Xu J, Zhao X., Free PMC Article | 12/28/2019 |
| Expression levels of ORMDL3, phosphorylated (p)ERK and MMP9 were significantly greater in the asthmamodel group; however, in the group pretreated with budesonide their expression was reduced. | ORMDL3 is associated with airway remodeling in asthma via the ERK/MMP-9 pathway.
Yu F, Sun Y, Yu J, Ding Z, Wang J, Zhang L, Zhang T, Bai Y, Wang Y., Free PMC Article | 01/20/2018 |
| ORMDL3 mediates the autophagy via the ATF 6-Beclin1 autophagy pathway, and it facilitates the survival of splenic B cells via promoting autophagy and suppressing apoptosis | ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway.
Dang J, Bian X, Ma X, Li J, Long F, Shan S, Yuan Q, Xin Q, Li Y, Gao F, Gong Y, Liu Q. | 09/30/2017 |
| ORMDL3 might influence de novo sphingolipid metabolism downstream of serine palmitoyltransferase | ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase.
Zhakupova A, Debeuf N, Krols M, Toussaint W, Vanhoutte L, Alecu I, Kutalik Z, Vollenweider P, Ernst D, von Eckardstein A, Lambrecht BN, Janssens S, Hornemann T. | 09/23/2017 |
| inhibiting ORMDL3 in airway epithelial cells plays a significant role in induction of allergen-induced increases in airway hyperresponsiveness | Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.
Miller M, Tam AB, Mueller JL, Rosenthal P, Beppu A, Gordillo R, McGeough MD, Vuong C, Doherty TA, Hoffman HM, Niwa M, Broide DH., Free PMC Article | 09/16/2017 |
| ORMDL3, an asthma susceptibility gene identified by genome-wide association studies, contributes to key pathways that promote changes in airway physiology during allergic immune responses. | Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.
Löser S, Gregory LG, Zhang Y, Schaefer K, Walker SA, Buckley J, Denney L, Dean CH, Cookson WOC, Moffatt MF, Lloyd CM., Free PMC Article | 08/19/2017 |
| Mediated by GATA3 through targeting promoter region of ORMDL3. | [Recombinant platanus pollen allergen 2 (rPla a2) up-regulates the expression of ORMDL3 mediated by GATA3 in NIH3T3 cells].
Zhang H, Zhuang L, Jin R, Li N, Zhou G. | 07/15/2017 |
| Downregulation of ORMDL3 expression in mast cells enhances AKT and NF-kappaB-directed signaling pathways and chemotaxis and contributes to the development of mast cell-mediated local inflammation in vivo. | Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells.
Bugajev V, Halova I, Draberova L, Bambouskova M, Potuckova L, Draberova H, Paulenda T, Junyent S, Draber P., Free PMC Article | 07/2/2016 |