| Deletion of Dux ameliorates muscular dystrophy in mdx mice by attenuating oxidative stress via Nrf2. | Deletion of Dux ameliorates muscular dystrophy in mdx mice by attenuating oxidative stress via Nrf2.
Sun S, Zhai W, Zhang R, Cai N. | 08/1/2024 |
| Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader. | Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader.
Hu X, Huang X, Yang Y, Sun Y, Zhao Y, Zhang Z, Qiu D, Wu Y, Wu G, Lei L., Free PMC Article | 06/11/2024 |
| The homeobox transcription factor DUXBL controls exit from totipotency. | The homeobox transcription factor DUXBL controls exit from totipotency.
Vega-Sendino M, Lüttmann FF, Olbrich T, Chen Y, Kuenne C, Stein P, Tillo D, Carey GI, Zhong J, Savy V, Radonova L, Lu T, Saykali B, Kim KP, Domingo CN, Schüler L, Günther S, Bentsen M, Bosnakovski D, Schöler H, Kyba M, Maity TK, Jenkins LM, Looso M, Williams CJ, Kim J, Ruiz S., Free PMC Article | 04/27/2024 |
| Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction. | Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.
Spens AE, Sutliff NA, Bennett SR, Campbell AE, Tapscott SJ., Free PMC Article | 05/26/2023 |
| Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, gammaH2AX accumulation, and Bax/Bak-dependence. | Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, γH2AX accumulation, and Bax/Bak-dependence.
Masteika IF, Sathya A, Homma S, Miller BM, Boyce FM, Miller JB., Free PMC Article | 04/9/2022 |
| Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model. | Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model.
Lu-Nguyen N, Malerba A, Herath S, Dickson G, Popplewell L., Free PMC Article | 03/26/2022 |
| iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling. | iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling.
Guo D, Daman K, Chen JJ, Shi MJ, Yan J, Matijasevic Z, Rickard AM, Bennett MH, Kiselyov A, Zhou H, Bang AG, Wagner KR, Maehr R, King OD, Hayward LJ, Emerson CP Jr., Free PMC Article | 03/5/2022 |
| RIPK3-mediated cell death is involved in DUX4-mediated toxicity in facioscapulohumeral dystrophy. | RIPK3-mediated cell death is involved in DUX4-mediated toxicity in facioscapulohumeral dystrophy.
Mariot V, Joubert R, Le Gall L, Sidlauskaite E, Hourde C, Duddy W, Voit T, Bencze M, Dumonceaux J., Free PMC Article | 02/5/2022 |
| Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy. | Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy.
Saad NY, Al-Kharsan M, Garwick-Coppens SE, Chermahini GA, Harper MA, Palo A, Boudreau RL, Harper SQ., Free PMC Article | 01/15/2022 |
| Functional study of distinct domains of Dux in improving mouse SCNT embryonic developmentdagger. | Functional study of distinct domains of Dux in improving mouse SCNT embryonic development†.
Huang X, Hu X, Jiang Q, Cao Q, Wu Y, Lei L. | 01/8/2022 |
| Dux facilitates post-implantation development, but is not essential for zygotic genome activationdagger. | Dux facilitates post-implantation development, but is not essential for zygotic genome activation†.
Bosnakovski D, Gearhart MD, Ho Choi S, Kyba M., Free PMC Article | 11/22/2021 |
| p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models. | p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models.
Grow EJ, Weaver BD, Smith CM, Guo J, Stein P, Shadle SC, Hendrickson PG, Johnson NE, Butterfield RJ, Menafra R, Kloet SL, van der Maarel SM, Williams CJ, Cairns BR., Free PMC Article | 09/11/2021 |
| Dnmt3b regulates DUX4 expression in a tissue-dependent manner in transgenic D4Z4 mice. | Dnmt3b regulates DUX4 expression in a tissue-dependent manner in transgenic D4Z4 mice.
Bouwman LF, den Hamer B, Verveer EP, Lerink LJS, Krom YD, van der Maarel SM, de Greef JC., Free PMC Article | 07/31/2021 |
| Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice. | Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice.
Bosnakovski D, Shams AS, Yuan C, da Silva MT, Ener ET, Baumann CW, Lindsay AJ, Verma M, Asakura A, Lowe DA, Kyba M., Free PMC Article | 02/2/2021 |
| DUX is important but not strictly essential for embryogenesis. | DUX is a non-essential synchronizer of zygotic genome activation.
De Iaco A, Verp S, Offner S, Grun D, Trono D., Free PMC Article | 07/4/2020 |
| Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells through Dux. | Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells.
Hu Z, Tan DEK, Chia G, Tan H, Leong HF, Chen BJ, Lau MS, Tan KYS, Bi X, Yang D, Ho YS, Wu B, Bao S, Wong ESM, Tee WW. | 04/18/2020 |
| The Duxbl initiates tumorigenesis by enforcing a mesenchymal-to-epithelial transition, and targeted inactivation of Duxbl specifically in Duxbl-expressing tumor cells abolishes their expansion. | Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype.
Preussner J, Zhong J, Sreenivasan K, Günther S, Engleitner T, Künne C, Glatzel M, Rad R, Looso M, Braun T, Kim J. | 10/19/2019 |
| p53 is not necessary for the cytotoxicity of DUX4, and that the p53 pathway is not generally activated by DUX4 in mouse model of facioscapulohumeral muscular dystrophy. | p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.
Bosnakovski D, Gearhart MD, Toso EA, Recht OO, Cucak A, Jain AK, Barton MC, Kyba M., Free PMC Article | 07/21/2018 |
| The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain. | The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.
Bosnakovski D, Toso EA, Hartweck LM, Magli A, Lee HA, Thompson ER, Dandapat A, Perlingeiro RCR, Kyba M., Free PMC Article | 06/16/2018 |
| DUX4 and Dux may regulate some common pathways, and despite diverging from a common progenitor under different selective pressures for millions of years, the two genes maintain partial functional homology. | Mouse Dux is myotoxic and shares partial functional homology with its human paralog DUX4.
Eidahl JO, Giesige CR, Domire JS, Wallace LM, Fowler AM, Guckes SM, Garwick-Coppens SE, Labhart P, Harper SQ., Free PMC Article | 03/3/2018 |
| Very low levels of DUX4 expression in skeletal muscle fibers lead to an expansion in the fibroadiopgenic progenitor compartment, and to a progressive fibrotic degeneration of skeletal muscles. | Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model.
Bosnakovski D, Chan SSK, Recht OO, Hartweck LM, Gustafson CJ, Athman LL, Lowe DA, Kyba M., Free PMC Article | 01/13/2018 |
| DUX role in activating cleavage-stage genes and MERVL/HERVL retrotransposons. | Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons.
Hendrickson PG, Doráis JA, Grow EJ, Whiddon JL, Lim JW, Wike CL, Weaver BD, Pflueger C, Emery BR, Wilcox AL, Nix DA, Peterson CM, Tapscott SJ, Carrell DT, Cairns BR., Free PMC Article | 09/16/2017 |
| DUX4 role in zygotic genome activation. | DUX-family transcription factors regulate zygotic genome activation in placental mammals.
De Iaco A, Planet E, Coluccio A, Verp S, Duc J, Trono D., Free PMC Article | 09/16/2017 |
| DUX activate genes associated with a cleavage-stage embryos in muscle cells. | Conservation and innovation in the DUX4-family gene network.
Whiddon JL, Langford AT, Wong CJ, Zhong JW, Tapscott SJ., Free PMC Article | 09/16/2017 |
| Transcriptomic analysis showed that DUX4 operates through both target gene activation and repression to orchestrate a transcriptome characteristic of a less-differentiated cell state. | DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis.
Knopp P, Krom YD, Banerji CR, Panamarova M, Moyle LA, den Hamer B, van der Maarel SM, Zammit PS., Free PMC Article | 08/5/2017 |