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    MIR539 microRNA 539 [ Homo sapiens (human) ]

    Gene ID: 664612, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-beta/Smads/MAPK.

    miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK.
    Dai Q, Shi R, Zhang G, Wang Y, Ye L, Peng L, Guo S, He J, Yang H, Jiang Y., Free PMC Article

    03/25/2024
    LncRNA TP73-AS1 enhances the malignant properties of colorectal cancer by increasing SPP-1 expression through miRNA-539-5p sponging.

    LncRNA TP73-AS1 enhances the malignant properties of colorectal cancer by increasing SPP-1 expression through miRNA-539-5p sponging.
    Ding C, Zhang K, Chen Y, Hu H.

    03/15/2023
    Regulation of Iron-Ion Transporter SLC11A2 by Three Identical miRNAs.

    Regulation of Iron-Ion Transporter SLC11A2 by Three Identical miRNAs.
    Sugino Y, Uchiyama R, Shibasaki C, Kugawa F.

    09/10/2022
    lncRNA LINC000466 Predicts the Prognosis and Promotes the Progression of Triple-negative Breast Cancer via Modulating miR-539-5p.

    lncRNA LINC000466 Predicts the Prognosis and Promotes the Progression of Triple-negative Breast Cancer via Modulating miR-539-5p.
    Liu J, Yu H, Cui H, Wei F, Yan T, Li T, Liu Y, Chu J.

    06/11/2022
    Recombinant water stress protein 1 (Re-WSP1) suppresses colon cancer cell growth through the miR-539/beta-catenin signaling pathway.

    Recombinant water stress protein 1 (Re-WSP1) suppresses colon cancer cell growth through the miR-539/β-catenin signaling pathway.
    Guo S, Shan S, Wu H, Hao H, Li Z.

    02/26/2022
    miR-539 Targeting SNAI2 Regulates MMP9 Signaling Pathway and Affects Blood-Brain Barrier Permeability in Cerebrovascular Occlusive Diseases: A Study Based on Head and Neck Ultrasound and CTA.

    miR-539 Targeting SNAI2 Regulates MMP9 Signaling Pathway and Affects Blood-Brain Barrier Permeability in Cerebrovascular Occlusive Diseases: A Study Based on Head and Neck Ultrasound and CTA.
    Li H, Han G, He D, Wang Y, Lin Y, Zhang T, Wang J, Du Y, Li G, Wang Y, Zhou J, Liu B., Free PMC Article

    01/29/2022
    Circ_0004104 Accelerates the Progression of Gastric Cancer by Regulating the miR-539-3p/RNF2 Axis.

    Circ_0004104 Accelerates the Progression of Gastric Cancer by Regulating the miR-539-3p/RNF2 Axis.
    Yue F, Peng K, Zhang L, Zhang J.

    12/11/2021
    Amniotic fluid microRNA profiles in twin-twin transfusion syndrome with and without severe recipient cardiomyopathy.

    Amniotic fluid microRNA profiles in twin-twin transfusion syndrome with and without severe recipient cardiomyopathy.
    Willner EC, Galan HL, Cuneo BF, Hoffman HA, Neltner B, Schuchardt EL, Karimpour-Fard A, Miyamoto SD, Sucharov CC., Free PMC Article

    10/30/2021
    LncRNA TP73-AS1/miR-539/MMP-8 axis modulates M2 macrophage polarization in hepatocellular carcinoma via TGF-beta1 signaling.

    LncRNA TP73-AS1/miR-539/MMP-8 axis modulates M2 macrophage polarization in hepatocellular carcinoma via TGF-β1 signaling.
    Chen J, Huang ZB, Liao CJ, Hu XW, Li SL, Qi M, Fan XG, Huang Y.

    10/23/2021
    LncRNA PCGEM1 contributes to malignant behaviors of glioma by regulating miR-539-5p/CDK6 axis.

    LncRNA PCGEM1 contributes to malignant behaviors of glioma by regulating miR-539-5p/CDK6 axis.
    Liu SL, Chen MH, Wang XB, You RK, An XW, Zhao Q, Wang RS., Free PMC Article

    07/24/2021
    MiR-539-5p Decreases amyloid beta-protein production, hyperphosphorylation of Tau and Memory Impairment by Regulating PI3K/Akt/GSK-3beta Pathways in APP/PS1 Double Transgenic Mice.

    MiR-539-5p Decreases amyloid β-protein production, hyperphosphorylation of Tau and Memory Impairment by Regulating PI3K/Akt/GSK-3β Pathways in APP/PS1 Double Transgenic Mice.
    Jiang Y, Zhang Y, Su L.

    06/19/2021
    A SNP-mediated lncRNA (LOC146880) and microRNA (miR-539-5p) interaction and its potential impact on the NSCLC risk.

    A SNP-mediated lncRNA (LOC146880) and microRNA (miR-539-5p) interaction and its potential impact on the NSCLC risk.
    Feng T, Feng N, Zhu T, Li Q, Zhang Q, Wang Y, Gao M, Zhou B, Yu H, Zheng M, Qian B., Free PMC Article

    05/1/2021
    LINC00460 promotes proliferation and inhibits apoptosis of non-small cell lung cancer cells through targeted regulation of miR-539.

    LINC00460 promotes proliferation and inhibits apoptosis of non-small cell lung cancer cells through targeted regulation of miR-539.
    Wang HX, Kang LJ, Qin X, Xu J, Fei JW.

    04/17/2021
    CASC21, a FOXP1 induced long non-coding RNA, promotes colorectal cancer growth by regulating CDK6.

    CASC21, a FOXP1 induced long non-coding RNA, promotes colorectal cancer growth by regulating CDK6.
    Gong T, Li Y, Feng L, Fang M, Dai G, Huang X, Yang Y, Liu S., Free PMC Article

    03/13/2021
    MiR-539 inhibits the malignant behavior of breast cancer cells by targeting SP1.

    MiR-539 inhibits the malignant behavior of breast cancer cells by targeting SP1.
    Cai F, Chen L, Sun Y, He C, Fu D, Tang J.

    02/27/2021
    LncRNA LUCAT1 contributes to cell proliferation and migration in human pancreatic ductal adenocarcinoma via sponging miR-539.

    LncRNA LUCAT1 contributes to cell proliferation and migration in human pancreatic ductal adenocarcinoma via sponging miR-539.
    Nai Y, Pan C, Hu X, Ma Y., Free PMC Article

    02/6/2021
    miR539 suppresses the proliferation, migration, invasion and epithelial mesenchymal transition of pancreatic cancer cells through targeting SP1.

    miR‑539 suppresses the proliferation, migration, invasion and epithelial mesenchymal transition of pancreatic cancer cells through targeting SP1.
    Xue L, Shen Y, Zhai Z, Zheng S., Free PMC Article

    01/23/2021
    lncRNA CRNDE promotes the proliferation and metastasis by acting as sponge miR-539-5p to regulate POU2F1 expression in HCC.

    lncRNA CRNDE promotes the proliferation and metastasis by acting as sponge miR-539-5p to regulate POU2F1 expression in HCC.
    Li Z, Wu G, Li J, Wang Y, Ju X, Jiang W., Free PMC Article

    01/9/2021
    LncRNA-ZNF281 Interacts with miR-539 to Promote Hepatocellular Carcinoma Cell Invasion and Migration.

    LncRNA-ZNF281 Interacts with miR-539 to Promote Hepatocellular Carcinoma Cell Invasion and Migration.
    Zhang Z, Yang L, Yao X, Yang M, Li G.

    11/28/2020
    MicroRNA-539 functions as a tumour suppressor in prostate cancer via the TGF-beta/Smad4 signalling pathway by down-regulating DLX1.

    MicroRNA-539 functions as a tumour suppressor in prostate cancer via the TGF-β/Smad4 signalling pathway by down-regulating DLX1.
    Sun B, Fan Y, Yang A, Liang L, Cao J., Free PMC Article

    08/29/2020
    MiR-539-3p promotes the progression of epithelial ovarian cancer by targeting SPARCL1.

    MiR-539-3p promotes the progression of epithelial ovarian cancer by targeting SPARCL1.
    Gong YB, Fan XH.

    08/13/2020
    Low miR539 expression is associated with gastric cancer.

    Downregulation miR-539 is associated with poor prognosis of gastric cancer patients and aggressive progression of gastric cancer cells.
    Jin W, Han H, Liu D.

    03/21/2020
    The results of the current study present evidence emphasizing the significance of the interactions between miR-539 and TWIST1 in the development of and progression of PC.

    MiR-539 functions as a tumor suppressor in pancreatic cancer by targeting TWIST1.
    Yu H, Gao G, Cai J, Song H, Ma Z, Jin X, Ji W, Pan B.

    02/15/2020
    The results revealed low expression of miR539 and high expression of SOX5 in gastric cancer tissues and cells as compared with the levels in normal tissues and cells, suggesting that there was a negative correlation between miR539 and SOX5.

    MicroRNA‑539 inhibits the proliferation and migration of gastric cancer cells by targeting SRY‑box 5 gene.
    Ding S, Zhang Y., Free PMC Article

    01/18/2020
    miR-539 was downregulated in WT tissues. And miR-539 inhibited the progression of WT through negatively regulating JAG1-Notch1/3 expression. MiR-539 should be a valuable indicator of the diagnosis and prognosis of WT.

    MicroRNA-539 inhibits the progression of Wilms' Tumor through downregulation of JAG1 and Notch1/3.
    Su H, Wang X, Song J, Wang Y, Zhao Y, Meng J., Free PMC Article

    06/15/2019
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