| SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma. | SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma.
Fu R, Xue W, Liang J, Li X, Zheng J, Wang L, Zhang M, Meng J., Free PMC Article | 06/10/2024 |
| Sterol O-Acyltransferase 1 (SOAT1): A Genetic Modifier of Niemann-Pick Disease, Type C1. | Sterol O-Acyltransferase 1 (SOAT1): A Genetic Modifier of Niemann-Pick Disease, Type C1.
Farhat NY, Alexander D, McKee K, Iben J, Rodriguez-Gil JL, Wassif CA, Cawley NX, Balch WE, Porter FD., Free PMC Article | 05/20/2024 |
| High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer. | High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer.
Eckhardt C, Sbiera I, Krebs M, Sbiera S, Spahn M, Kneitz B, Joniau S, Fassnacht M, Kübler H, Weigand I, Kroiss M., Free PMC Article | 08/27/2022 |
| High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth. | High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth.
Wang Z, Wang M, Zhang M, Xu K, Zhang X, Xie Y, Zhang Y, Chang C, Li X, Sun A, He F., Free PMC Article | 08/20/2022 |
| SOAT1 is a new prognostic factor of colorectal cancer. | SOAT1 is a new prognostic factor of colorectal cancer.
Wang XC, Luo LM, Huang TS, Feng LF. | 07/30/2022 |
| SOAT1 enhances lung cancer invasiveness by stimulating AKT-mediated mitochondrial fragmentation. | SOAT1 enhances lung cancer invasiveness by stimulating AKT-mediated mitochondrial fragmentation.
Mo Y, Lin L, Zhang J, Yu C. | 05/14/2022 |
| SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma? | SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?
Löhr M, Härtig W, Schulze A, Kroiß M, Sbiera S, Lapa C, Mages B, Strobel S, Hundt JE, Bohnert S, Kircher S, Janaki-Raman S, Monoranu CM., Free PMC Article | 04/23/2022 |
| piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure. | piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure.
Zhong N, Nong X, Diao J, Yang G., Free PMC Article | 04/16/2022 |
| Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study). | Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study).
Alavez-Rubio JS, Martínez-Rodríguez N, Escobedo-de-la-Peña J, Garrido-Acosta O, Juárez-Cedillo T. | 10/30/2021 |
| Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma. | Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma.
Chen Y, Yang X, Chen Y, Chen G, Winkler CA, An P, Lyu J., Free PMC Article | 10/23/2021 |
| SOAT1 promotes mevalonate pathway dependency in pancreatic cancer. | SOAT1 promotes mevalonate pathway dependency in pancreatic cancer.
Oni TE, Biffi G, Baker LA, Hao Y, Tonelli C, Somerville TDD, Deschênes A, Belleau P, Hwang CI, Sánchez-Rivera FJ, Cox H, Brosnan E, Doshi A, Lumia RP, Khaledi K, Park Y, Trotman LC, Lowe SW, Krasnitz A, Vakoc CR, Tuveson DA., Free PMC Article | 03/6/2021 |
| A Dipeptidyl Peptidase-4 Inhibitor Inhibits Foam Cell Formation of Macrophages in Type 1 Diabetes via Suppression of CD36 and ACAT-1 Expression. | A Dipeptidyl Peptidase-4 Inhibitor Inhibits Foam Cell Formation of Macrophages in Type 1 Diabetes via Suppression of CD36 and ACAT-1 Expression.
Terasaki M, Yashima H, Mori Y, Saito T, Matsui T, Hiromura M, Kushima H, Osaka N, Ohara M, Fukui T, Hirano T, Yamagishi SI., Free PMC Article | 02/27/2021 |
| Association Between LOX-1, LAL, and ACAT1 Gene Single Nucleotide Polymorphisms and Carotid Plaque in a Northern Chinese Population. | Association Between LOX-1, LAL, and ACAT1 Gene Single Nucleotide Polymorphisms and Carotid Plaque in a Northern Chinese Population.
Zhang Q, Chu Y, Jin G, Dai J, Kang H. | 10/24/2020 |
| cryo-electron microscopy structure of human ACAT1(SOAT1) as a dimer of dimers; structural and biochemical characterization helps to rationalize the preference of ACAT1 for unsaturated acyl chains, and provides insight into the catalytic mechanism of enzymes within the MBOAT family | Structural basis for catalysis and substrate specificity of human ACAT1.
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N. | 07/18/2020 |
| cryo-electron microscopy structure of human ACAT1 (SOAT1) in complex with nevanimibe, an inhibitor that is in clinical trials for the treatment of congenital adrenal hyperplasia | Structure of nevanimibe-bound tetrameric human ACAT1.
Long T, Sun Y, Hassan A, Qi X, Li X., Free PMC Article | 07/11/2020 |
| the expression and contribution of ACAT-1 (SOAT1) in ovarian cancer progression, was examined. | Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression-An in vitro study.
Ayyagari VN, Wang X, Diaz-Sylvester PL, Groesch K, Brard L., Free PMC Article | 04/25/2020 |
| There was a significant difference and a higher frequency of AA and AC genotypes (p = 0.047 and p = 0.016, respectively) of the SOAT1 (ACAT-1) gene in asymptomatic chagasic individuals. | ACAT-1 gene rs1044925 SNP and its relation with different clinical forms of chronic Chagas disease.
Carvalho TB, Padovani CR, de Oliveira Júnior LR, Latini ACP, Kurokawa CS, Pereira PCM, Dos Santos RM. | 10/26/2019 |
| the transcription factor signal transducer and activator of transcription 3 was activated by TB-PE, and its chemical inhibition prevented the accumulation of lipid bodies and ACAT expression in macrophages. In terms of the host immune response, TB-PE-treated macrophages displayed immunosuppressive properties and bore higher bacillary loads. | Formation of Foamy Macrophages by Tuberculous Pleural Effusions Is Triggered by the Interleukin-10/Signal Transducer and Activator of Transcription 3 Axis through ACAT Upregulation.
Genoula M, Marín Franco JL, Dupont M, Kviatcovsky D, Milillo A, Schierloh P, Moraña EJ, Poggi S, Palmero D, Mata-Espinosa D, González-Domínguez E, León Contreras JC, Barrionuevo P, Rearte B, Córdoba Moreno MO, Fontanals A, Crotta Asis A, Gago G, Cougoule C, Neyrolles O, Maridonneau-Parini I, Sánchez-Torres C, Hernández-Pando R, Vérollet C, Lugo-Villarino G, Sasiain MDC, Balboa L., Free PMC Article | 04/27/2019 |
| Soat-1 role in atherosclerosis | SOAT1 deficiency attenuates atherosclerosis by regulating inflammation and cholesterol transportation via HO-1 pathway.
Wu N, Li RQ, Li L. | 11/10/2018 |
| Several residues in one subunit closely interact with the same residues in the other subunit; mutating these res. to Cys does not lead to loss in enzyme activity. Mutating residues F453, A457, or H460 to Cys causes large loss in enzyme activity. | Functionality of the seventh and eighth transmembrane domains of acyl-coenzyme A:cholesterol acyltransferase 1.
Guo ZY, Chang CC, Chang TY. | 06/1/2018 |
| increase in the in vitro ACAT1 activity in PC-3 prostate cancer cells treated with androgen | Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT).
Locke JA, Wasan KM, Nelson CC, Guns ES, Leon CG. | 06/1/2018 |
| The results suggest that rs1044925 polymorphism in ACAT1 gene is not only associated with serum LDL-C and nHDLC levels in healthy Chinese subjects in Chengdu area, but also with HDL-C level in subjects with endogenous hypertriglyceridemia. | [Analysis of acyl-coenzyme A: cholesterol acyltransferase 1 polymorphism in patients with endogenous hypertriglyceridemia in Chinese population].
Li Q, Bai H, Fan P. | 06/1/2018 |
| RNA secondary structures located in the vicinity of the GGC(1274-1276) codon are required for production of the 56-kDa isoform. | RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform.
Chen J, Zhao XN, Yang L, Hu GJ, Lu M, Xiong Y, Yang XY, Chang CC, Song BL, Chang TY, Li BL., Free PMC Article | 06/1/2018 |
| ACAT inhibition may stimulate cholesterol-catabolic (cytochrome P450) pathway in lesion-macrophages. | Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes.
An S, Jang YS, Park JS, Kwon BM, Paik YK, Jeong TS., Free PMC Article | 06/1/2018 |
| Angiotensin II enhances foam cell formation by upregulating ACAT1 expression predominantly through the actions of AT(1) receptor via the G protein/c-Src/PKC/MAPK pathway in human monocyte-macrophages | Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages.
Kanome T, Watanabe T, Nishio K, Takahashi K, Hongo S, Miyazaki A. | 06/1/2018 |