| Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. | Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction.
Rios L, Pokhrel S, Li SJ, Heo G, Haileselassie B, Mochly-Rosen D., Free PMC Article | 07/24/2023 |
| Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance. | Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance.
Mukherjee R, Tompkins CA, Ostberg NP, Joshi AU, Massis LM, Vijayan V, Gera K, Monack D, Cornell TT, Hall MW, Mochly-Rosen D, Haileselassie B., Free PMC Article | 06/11/2022 |
| DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury. | DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury.
Wang S, Zhu H, Li R, Mui D, Toan S, Chang X, Zhou H. | 04/9/2022 |
| Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis. | Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis.
Liou YH, Personnaz J, Jacobi D, Knudsen NH, Chalom MM, Starost KA, Nnah IC, Lee CH., Free PMC Article | 04/2/2022 |
| Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation. | Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.
Varuzhanyan G, Ladinsky MS, Yamashita SI, Abe M, Sakimura K, Kanki T, Chan DC., Free PMC Article | 10/30/2021 |
| miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1. | miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1.
Kato M, Abdollahi M, Tunduguru R, Tsark W, Chen Z, Wu X, Wang J, Chen ZB, Lin FM, Lanting L, Wang M, Huss J, Fueger PT, Chan D, Natarajan R., Free PMC Article | 07/3/2021 |
| Treatment with P110 was protective in both in vitro and in vivo models of septic cardiomyopathy, suggesting a key role of Drp1/Fis1 interaction, and a potential target to reduce its morbidity and mortality. | Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy.
Haileselassie B, Mukherjee R, Joshi AU, Napier BA, Massis LM, Ostberg NP, Queliconi BB, Monack D, Bernstein D, Mochly-Rosen D., Free PMC Article | 06/20/2020 |
| Fis1 loss induced delayed onset muscle ultrastructure change (DOMUC) in Type I muscle and strong inflammation in response to acute exhaustive exercise (EE). | Fis1 deficiencies differentially affect mitochondrial quality in skeletal muscle.
Zhang Z, Sliter DA, Bleck CKE, Ding S., Free PMC Article | 05/9/2020 |
| a role for Drp1/Fis1-mediated excessive mitochondrial fission and dysfunction, is reported. | Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.
Joshi AU, Ebert AE, Haileselassie B, Mochly-Rosen D., Free PMC Article | 01/11/2020 |
| chronically elevated IL-6 can directly induce DRP-1 and FIS-1 expression through gp130 signaling in cultured myotubes and skeletal muscle. | Regulation of Skeletal Muscle DRP-1 and FIS-1 Protein Expression by IL-6 Signaling.
Fix DK, VanderVeen BN, Counts BR, Carson JA., Free PMC Article | 04/20/2019 |
| Our data confirm that FIS1 is a key regulator in pancreatic beta cells, because both glucose-stimulated insulin secretion and mitochondrial dynamics were clearly adapted to precise expression levels of this fission protein. | Precise expression of Fis1 is important for glucose responsiveness of beta cells.
Schultz J, Waterstradt R, Kantowski T, Rickmann A, Reinhardt F, Sharoyko V, Mulder H, Tiedge M, Baltrusch S. | 06/24/2017 |
| MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria. | Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.
Palmer CS, Elgass KD, Parton RG, Osellame LD, Stojanovski D, Ryan MT., Free PMC Article | 11/30/2013 |
| we find that either MiD49 or MiD51 can mediate Drp1 recruitment and mitochondrial fission in the absence of Fis1 and Mff | Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.
Losón OC, Song Z, Chen H, Chan DC., Free PMC Article | 09/14/2013 |
| miR-484 attenuate Fis1 and mitochondrial fission by binding to N-terminal of Fis1 and inhibiting its translation. | miR-484 regulates mitochondrial network through targeting Fis1.
Wang K, Long B, Jiao JQ, Wang JX, Liu JP, Li Q, Li PF. | 07/28/2012 |
| study provides the first evidence that homocysteine-induced ganglion cell loss involves the dysregulation of mitochondrial dynamics, both in vivo and in vitro. | Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells.
Ganapathy PS, Perry RL, Tawfik A, Smith RM, Perry E, Roon P, Bozard BR, Ha Y, Smith SB., Free PMC Article | 10/1/2011 |