| Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice. | Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice.
Mareedu S, Fefelova N, Galindo CL, Prakash G, Mukai R, Sadoshima J, Xie LH, Babu GJ., Free PMC Article | 05/10/2024 |
| Reducing sarcolipin expression improves muscle metabolism in mdx mice. | Reducing sarcolipin expression improves muscle metabolism in mdx mice.
Balakrishnan R, Mareedu S, Babu GJ., Free PMC Article | 02/19/2022 |
| Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice. | Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice.
Mareedu S, Pachon R, Thilagavathi J, Fefelova N, Balakrishnan R, Niranjan N, Xie LH, Babu GJ., Free PMC Article | 02/6/2021 |
| reducing expression of sarcolipin expression can improve the Cai2+ cycling and differentiation of dystrophic myoblasts | Sarcolipin overexpression impairs myogenic differentiation in Duchenne muscular dystrophy.
Niranjan N, Mareedu S, Tian Y, Kodippili K, Fefelova N, Voit A, Xie LH, Duan D, Babu GJ., Free PMC Article | 04/11/2020 |
| our findings demonstrate a critical role for SLN upregulation in dystrophic muscles and suggest that SLN can be viewed as a potential therapeutic target. | Sarcolipin deletion in mdx mice impairs calcineurin signalling and worsens dystrophic pathology.
Fajardo VA, Chambers PJ, Juracic ES, Rietze BA, Gamu D, Bellissimo C, Kwon F, Quadrilatero J, Russell Tupling A., Free PMC Article | 05/18/2019 |
| SLN overexpression is associated with severe muscle atrophy and weakness. | Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice.
Fajardo VA, Gamu D, Mitchell A, Bloemberg D, Bombardier E, Chambers PJ, Bellissimo C, Quadrilatero J, Tupling AR., Free PMC Article | 09/9/2017 |
| SLN plays an important role in adaptive muscle remodeling potentially through calcineurin stimulation, which could have important implications for other muscle diseases and conditions | Effects of sarcolipin deletion on skeletal muscle adaptive responses to functional overload and unload.
Fajardo VA, Rietze BA, Chambers PJ, Bellissimo C, Bombardier E, Quadrilatero J, Tupling AR. | 08/19/2017 |
| Cardiac function of Sln(Cre/+) mice was not significantly different from WT mice in all aspects that were examined. | Heterozygous deletion of sarcolipin maintains normal cardiac function.
Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S. | 05/7/2016 |
| increased expression improves skeletal muscle performance during prolonged muscle activity by increasing store-operated calcium entry and muscle energetics | Sarcolipin overexpression improves muscle energetics and reduces fatigue.
Sopariwala DH, Pant M, Shaikh SA, Goonasekera SA, Molkentin JD, Weisleder N, Ma J, Pan Z, Periasamy M., Free PMC Article | 01/30/2016 |
| the N termini of SLN and PLB influence their respective unique functions | The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca2+-ATPase (SERCA) ATP Hydrolysis from Ca2+ Transport.
Sahoo SK, Shaikh SA, Sopariwala DH, Bal NC, Bruhn DS, Kopec W, Khandelia H, Periasamy M., Free PMC Article | 08/22/2015 |
| UCP1 and SLN are required to maintain optimal thermogenesis and loss of both systems compromises survival of mice under cold stress | Uncoupling Protein 1 and Sarcolipin Are Required to Maintain Optimal Thermogenesis, and Loss of Both Systems Compromises Survival of Mice under Cold Stress.
Rowland LA, Bal NC, Kozak LP, Periasamy M., Free PMC Article | 08/8/2015 |
| both SLN knockout (Sln(-/-)) and skeletal muscle-specific SLN overexpression (Sln(OE)) mice to explore energy metabolism by pair feeding (fixed calories) and high-fat diet feeding (ad libitum) | Sarcolipin Is a Key Determinant of the Basal Metabolic Rate, and Its Overexpression Enhances Energy Expenditure and Resistance against Diet-induced Obesity.
Maurya SK, Bal NC, Sopariwala DH, Pant M, Rowland LA, Shaikh SA, Periasamy M., Free PMC Article | 08/1/2015 |
| overexpression of neither wild type nor FLAG-tagged variants of sarcolipin in transgenic mice had any major significant effects on body mass, energy expenditure, even when mice were fed on a high fat diet | The effects of sarcolipin over-expression in mouse skeletal muscle on metabolic activity.
Butler J, Smyth N, Broadbridge R, Council CE, Lee AG, Stocker CJ, Hislop DC, Arch JR, Cawthorne MA, Malcolm East J., Free PMC Article | 06/27/2015 |
| SLN and PLN are co-expressed in most fibers, which suggests that super-inhibition of SERCAs may be physiologically important in the regulation of intracellular Ca2+ in human skeletal muscle. | Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers.
Fajardo VA, Bombardier E, Vigna C, Devji T, Bloemberg D, Gamu D, Gramolini AO, Quadrilatero J, Tupling AR., Free PMC Article | 09/20/2014 |
| results suggest that beta-AR signaling partially compensates for a lack of SLN to activate muscle-based DIT, but SLN is the primary and more effective mediator. | Sarcolipin trumps β-adrenergic receptor signaling as the favored mechanism for muscle-based diet-induced thermogenesis.
Bombardier E, Smith IC, Gamu D, Fajardo VA, Vigna C, Sayer RA, Gupta SC, Bal NC, Periasamy M, Tupling AR., Free PMC Article | 11/16/2013 |
| Sarcolipin deficiency increases the transport stoichiometry of SERCA pumps and decreases the relative contribution of SERCA pumps to resting oxygen consumption. | Ablation of sarcolipin decreases the energy requirements for Ca2+ transport by sarco(endo)plasmic reticulum Ca2+-ATPases in resting skeletal muscle.
Bombardier E, Smith IC, Vigna C, Fajardo VA, Tupling AR. | 07/27/2013 |
| Data indicate that phospholamban (PLB) is not involved in heat generation and that sarcolipin (SLN) alone is responsible for muscle thermogenesis. | Sarcolipin protein interaction with sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) is distinct from phospholamban protein, and only sarcolipin can promote uncoupling of the SERCA pump.
Sahoo SK, Shaikh SA, Sopariwala DH, Bal NC, Periasamy M., Free PMC Article | 05/4/2013 |
| During mouse muscle development SLN is highly expressed in embryonic muscle and plays role in regulation of sarcoplasmic reticulum Ca(2+) stores during muscle differentiation | Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.
Seth M, Li T, Graham V, Burch J, Finch E, Stiber JA, Rosenberg PB., Free PMC Article | 04/27/2013 |
| data collectively suggest that SLN is an important mediator of muscle thermogenesis and whole-body energy metabolism | Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.
Bal NC, Maurya SK, Sopariwala DH, Sahoo SK, Gupta SC, Shaikh SA, Pant M, Rowland LA, Bombardier E, Goonasekera SA, Tupling AR, Molkentin JD, Periasamy M., Free PMC Article | 01/12/2013 |
| ablation of SLN results in increased SERCA activity and sarcoplasmic reticulum Ca(2+) load, which, in turn, could cause abnormal intracellular Ca(2+) handling and atrial remodeling. | Ablation of sarcolipin results in atrial remodeling.
Xie LH, Shanmugam M, Park JY, Zhao Z, Wen H, Tian B, Periasamy M, Babu GJ., Free PMC Article | 08/25/2012 |
| These results show that sarcolepin (SLN) regulates Ca(2+)-ATPase activity, the functional significance of SLN is graded to the SLN expression level, and SLN inhibitory effects on SERCA function are relieved in response to repeated contractions. | Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice.
Tupling AR, Bombardier E, Gupta SC, Hussain D, Vigna C, Bloemberg D, Quadrilatero J, Trivieri MG, Babu GJ, Backx PH, Periasamy M, MacLennan DH, Gramolini AO., Free PMC Article | 11/19/2011 |
| Dynamic regulation of the SERCA pump by phospholamban and/or sarcolipin maintains cardiac contractility in normal conditions and during pathophysiological states. | Ablation of phospholamban and sarcolipin results in cardiac hypertrophy and decreased cardiac contractility.
Shanmugam M, Gao S, Hong C, Fefelova N, Nowycky MC, Xie LH, Periasamy M, Babu GJ., Free PMC Article | 04/23/2011 |
| Studies suggest sln and uchl1 genes as novel targets of AT deficiency and may offer molecular correlates of well documented descriptions of neuromuscular dysfunctions in AT-deficient rodents. | Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice.
Vasu VT, Ott S, Hobson B, Rashidi V, Oommen S, Cross CE, Gohil K., Free PMC Article | 01/21/2010 |
| Sarcolipin is a key regulator of SERCA2a Calcium ATPase in heart atria. | Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility.
Babu GJ, Bhupathy P, Timofeyev V, Petrashevskaya NN, Reiser PJ, Chiamvimonvat N, Periasamy M., Free PMC Article | 01/21/2010 |
| sarcolipin is likely to be an atrial chamber-specific regulator of Ca2+ cycling in heart | Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling.
Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, Matsuoka R. | 01/21/2010 |