| Ahnak depletion accelerates liver regeneration by modulating the TGF-beta/Smad signaling pathway. | Ahnak depletion accelerates liver regeneration by modulating the TGF-β/Smad signaling pathway.
Yang I, Son Y, Shin JH, Kim IY, Seong JK., Free PMC Article | 09/3/2022 |
| Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction. | Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction.
Kim YN, Shin JH, Kyeong DS, Cho SY, Kim MY, Lim HJ, Jimenez MRR, Kim IY, Lee MO, Bae YS, Seong JK., Free PMC Article | 03/5/2022 |
| Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells. | Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells.
Suh JM, Son Y, Yoo JY, Goh Y, Seidah NG, Lee S, Bae YS., Free PMC Article | 02/5/2022 |
| Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior. | Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior.
Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GJ, Lee A, Gresack J, Greengard P, Kim Y., Free PMC Article | 03/20/2021 |
| TGFbeta-Ahnak signaling axis regulates epithelial-mesenchymal transition during tumor metastasis. | Ahnak promotes tumor metastasis through transforming growth factor-β-mediated epithelial-mesenchymal transition.
Sohn M, Shin S, Yoo JY, Goh Y, Lee IH, Bae YS., Free PMC Article | 11/30/2019 |
| Immortalized Ahnak knock-out SVF cells showed lower level of Bmpr1alpha expression. | Essential role of Ahnak in adipocyte differentiation leading to the transcriptional regulation of Bmpr1α expression.
Woo JK, Shin JH, Lee SH, Park HM, Cho SY, Sung YM, Kim IY, Seong JK., Free PMC Article | 11/16/2019 |
| Ahnak1 plays a protective role in vascular healing after wire injuries. | Protective Function of Ahnak1 in Vascular Healing after Wire Injury.
Haase N, Rüder C, Haase H, Kamann S, Kouno M, Morano I, Dechend R, Zohlnhöfer D, Haase T. | 06/24/2017 |
| Findings suggest an important role of AHNAK in the regulation of thermogenesis and lipolysis in white adipose tissue via beta-adrenergic signaling. | AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to β-adrenergic signalling.
Shin JH, Lee SH, Kim YN, Kim IY, Kim YJ, Kyeong DS, Lim HJ, Cho SY, Choi J, Wi YJ, Choi JH, Yoon YS, Bae YS, Seong JK., Free PMC Article | 01/28/2017 |
| AHNAK plays a crucial role in body fat accumulation by regulating adipose tissue development via interaction with the SMAD1 protein and can be involved in metabolic homeostasis | Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak-/- Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure.
Shin JH, Kim IY, Kim YN, Shin SM, Roh KJ, Lee SH, Sohn M, Cho SY, Lee SH, Ko CY, Kim HS, Choi CS, Bae YS, Seong JK., Free PMC Article | 06/11/2016 |
| inhibition of Ahnak can promote generation of induced pluripotent stem cells (iPSC) via up-regulation of endogenous c-Myc. | Regulation of c-Myc Expression by Ahnak Promotes Induced Pluripotent Stem Cell Generation.
Lim HJ, Kim J, Park CH, Lee SA, Lee MR, Kim KS, Kim J, Bae YS., Free PMC Article | 05/21/2016 |
| findings suggest that Ahnak might be involved in modulating the differentiation of newly generated cells into neuronal or non-neuronal cells | Increased Cell Proliferations and Neurogenesis in the Hippocampal Dentate Gyrus of Ahnak Deficient Mice.
Shin JH, Kim YN, Kim IY, Choi DH, Yi SS, Seong JK. | 04/16/2016 |
| Results suggest that by interfering in the cross-talk between the transmembrane form of the laminin receptor dystroglycan and F-actin, AHNAK1 influences the cytoskeleton organization of Schwann cells | Giant scaffolding protein AHNAK1 interacts with β-dystroglycan and controls motility and mechanical properties of Schwann cells.
von Boxberg Y, Soares S, Féréol S, Fodil R, Bartolami S, Taxi J, Tricaud N, Nothias F. | 03/21/2015 |
| Ahnak mediates a negative regulation of cell growth and acts as novel tumor suppressor through potentiation of TGFB signaling. | Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway.
Lee IH, Sohn M, Lim HJ, Yoon S, Oh H, Shin S, Shin JH, Oh SH, Kim J, Lee DK, Noh DY, Bae DS, Seong JK, Bae YS., Free PMC Article | 11/22/2014 |
| Ahnak protein plays an important scaffolding function connecting Erk and Rac activation in PDGF-dependent migration of aortic smooth muscle cells (ASMC). | Function of Ahnak protein in aortic smooth muscle cell migration through Rac activation.
Lim HJ, Kang DH, Lim JM, Kang DM, Seong JK, Kang SW, Bae YS. | 08/3/2013 |
| phosphorylation event is one mechanism underlying ahnak1's modulator function on Cav1.2 channel activity. | Ahnak1 interaction is affected by phosphorylation of Ser-296 on Cavβ₂.
Pankonien I, Otto A, Dascal N, Morano I, Haase H. | 07/14/2012 |
| these results indicate that ahnak1 is not essential for beta-adrenergic up-regulation of I (CaL) and cardiac contractility in mice. | Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel activity.
Pankonien I, Alvarez JL, Doller A, Köhncke C, Rotte D, Regitz-Zagrosek V, Morano I, Haase H. | 04/7/2012 |
| AHNAK constitutes a novel mechanism in post-transcriptional control of gene expression. | Self-regulated alternative splicing at the AHNAK locus.
de Morrée A, Droog M, Grand Moursel L, Bisschop IJ, Impagliazzo A, Frants RR, Klooster R, van der Maarel SM. | 03/3/2012 |
| these results demonstrate the exclusive expression of AHNAK1 and AHNAK2 in the costameres of adult skeletal muscles. | AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness.
Marg A, Haase H, Neumann T, Kouno M, Morano I. | 12/4/2010 |
| AHNAK1-deficient CTLs show marked reduction in granzyme-B production, cytolytic activity, and IFN-gamma secretion after T cell receptor stimulation. Our results demonstrate AHNAK1-dependent mechanism controlling calcium entry during CTL effector function | Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis.
Matza D, Badou A, Jha MK, Willinger T, Antov A, Sanjabi S, Kobayashi KS, Marchesi VT, Flavell RA., Free PMC Article | 01/21/2010 |
| Ca(v)1.2 and beta(2)-subunits and ahnak form a stable complex in osteoblastic cells that permits Ca(2+) signaling independently of association with the actin cytoskeleton | Dynamic interactions between L-type voltage-sensitive calcium channel Cav1.2 subunits and ahnak in osteoblastic cells.
Shao Y, Czymmek KJ, Jones PA, Fomin VP, Akanbi K, Duncan RL, Farach-Carson MC., Free PMC Article | 01/21/2010 |
| our results clearly show the implication of AHNAK in myelinating Schwann cell adhesion to laminin, probably via targeting of the dystroglycan-associated receptor complex | The giant protein AHNAK involved in morphogenesis and laminin substrate adhesion of myelinating Schwann cells.
Salim C, Boxberg YV, Alterio J, Féréol S, Nothias F. | 01/21/2010 |
| Ahnak potentiates PKC activation through inhibiting the interaction of PKC with PP2A. | Ahnak protein activates protein kinase C (PKC) through dissociation of the PKC-protein phosphatase 2A complex.
Lee IH, Lim HJ, Yoon S, Seong JK, Bae DS, Rhee SG, Bae YS. | 01/21/2010 |
| AHNAK mediates activation of phospholipase C-gamma1 through protein kinase C | AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.
Lee IH, You JO, Ha KS, Bae DS, Suh PG, Rhee SG, Bae YS. | 01/21/2010 |
| Ahnak/Desmoyokin deficiency has only a minimal effect on epidermal cell adhesion, tumorigenesis, cell proliferation and differentiation, and overall mouse development. | Ahnak/Desmoyokin is dispensable for proliferation, differentiation, and maintenance of integrity in mouse epidermis.
Kouno M, Kondoh G, Horie K, Komazawa N, Ishii N, Takahashi Y, Takeda J, Hashimoto T. | 01/21/2010 |
| Our results identify AHNAK as a protein marker of endothelial cells with barrier properties. | Specific AHNAK expression in brain endothelial cells with barrier properties.
Gentil BJ, Benaud C, Delphin C, Remy C, Berezowski V, Cecchelli R, Feraud O, Vittet D, Baudier J. | 01/21/2010 |