| Functional and topological analysis of PSENEN, the fourth subunit of the gamma-secretase complex. | Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex.
Serneels L, Bammens L, Zwijsen A, Tolia A, Chávez-Gutiérrez L, De Strooper B., Free PMC Article | 02/13/2024 |
| Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus. | Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus.
Xia Y, Zhang Y, Xu M, Zou X, Gao J, Ji MH, Chen G. | 06/11/2022 |
| Pen-2 Negatively Regulates the Differentiation of Oligodendrocyte Precursor Cells into Astrocytes in the Central Nervous System. | Pen-2 Negatively Regulates the Differentiation of Oligodendrocyte Precursor Cells into Astrocytes in the Central Nervous System.
Hou J, Bi H, Ye Z, Huang W, Zou G, Zou X, Shi YS, Shen Y, Ma Q, Kirchhoff F, Hu Y, Chen G., Free PMC Article | 11/22/2021 |
| Assembly of gamma-secretase occurs through stable dimers after exit from the endoplasmic reticulum. | Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
Wouters R, Michiels C, Sannerud R, Kleizen B, Dillen K, Vermeire W, Ayala AE, Demedts D, Schekman R, Annaert W., Free PMC Article | 11/13/2021 |
| Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/gamma-secretase at the cell surface. | Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface.
Escamilla-Ayala AA, Sannerud R, Mondin M, Poersch K, Vermeire W, Paparelli L, Berlage C, Koenig M, Chavez-Gutierrez L, Ulbrich MH, Munck S, Mizuno H, Annaert W., Free PMC Article | 02/20/2021 |
| Conditional inactivation of Pen-2 in the developing neocortex leads to rapid switch of apical progenitors to basal progenitors. | Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors.
Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Liang J, Stone Shi Y, Zheng Y, Lu J, Chen G., Free PMC Article | 03/21/2020 |
| Using knockout cell lines in combination with siRNA and immunoprecipitation approaches, our data clearly demonstrated that the Pen-2 and PS1 are sufficient to form a functionally active gamma-secretase that is capable of catalyzing the processing of Notch. This finding strongly suggests that Pen-2 is the most crucial component in gamma-secretase complex in addition to presenilin that functions as the catalytic subunit. | Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.
Hu C, Xu J, Zeng L, Li T, Cui MZ, Xu X., Free PMC Article | 02/24/2018 |
| Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome. | Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
Lokau J, Flynn CM, Garbers C. | 08/26/2017 |
| the G206D mutation reduced presenilin-1-presenilin enhancer 2 interaction, but did not abolish gamma-secretase formation and presenilin-1 endoproteolysis | G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH. | 09/3/2016 |
| Data show that the expression level of presenilin enhancer-2 (Pen-2) is relatively high in central nervous system at the early stages of postnatal development, but declines, gradually in adult mice. | Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice.
Chu Y, Peng X, Long Z, Wang K, Luo S, Sharma A, He G. | 01/23/2016 |
| rather than solely being a catalyst for gamma-secretase endoproteolysis, Pen-2 may also stabilize the complex prior to PS1 endoproteolysis, allowing time for full assembly and proper trafficking. | Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis.
Holmes O, Paturi S, Selkoe DJ, Wolfe MS., Free PMC Article | 09/13/2014 |
| Pen-2, as well as nicastrin and Aph-1alpha, is dispensable for presenilin endoproteolysis | Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment.
Mao G, Cui MZ, Li T, Jin Y, Xu X., Free PMC Article | 01/12/2013 |
| Nct has a critical role in the stability and proper intracellular trafficking of other components of the PS1/ gamma-secretase complex but not in maintaining the association of PEN-2, APH-1, and full-length PS1 | Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H., Free PMC Article | 01/21/2010 |